Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Islam A.A.E.-H. Ibrahim"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 408-412 (2012)
β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independe
Externí odkaz:
https://doaj.org/article/1c11f99d0c4c4d07bfb3b2ecb26c0303
Autor:
Mona F. Mahmoud, Hoda M.S. Ahmed, Samar G. Mohamed, Islam A.A.E.-H. Ibrahim, Amr A.A. Mahmoud, Wael S. Ibrahim, Asmaa M. Rezk
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 100:68-77
We aimed to investigate the acute and chronic effects of carvedilol on insulin resistance in high-fructose, high-fat diet (HFrHFD) – fed mice and the implication of the β-arrestin2 pathway. The acute effect of carvedilol (10 mg/kg, i.p.) on glucos
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 25:354-363
Background:Insulin resistance (IR) is a well-known risk factor for cardiovascular complications. This study aimed to investigate the effect of a dietary model of IR in mice on cardiac remodeling, cardiac β-arrestin2 signaling, and the protective eff
Publikováno v:
Zagazig Journal of Pharmaceutical Sciences. 28:1-12
Insulin resistance is a metabolic disorder associated with a wide array of cardiovascular complications. This study aimed to investigate the effect of oleic acid on a dietary model of insulin resistance in mice using high fructose high fat diet (HFrH
Publikováno v:
Pharmacology. 106(7-8)
Introduction: Pioglitazone is a thiazolidinedione oral antidiabetic agent. This study aimed to investigate the effects of pioglitazone as insulin sensitizer on β-arrestin2 signaling in classical insulin target tissues. Methods: Experiments involved
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 393(10)
Insulin resistance is a worldwide health problem. This study investigated the acute effects of eicosapentanoic acid (EPA) on glucose homeostasis focusing on the role of free fatty acid receptor 1 (FFAR1) and the chronic effects of fish oil omega-3 fa
Publikováno v:
Life Sciences. 286:120055
Aims β-Arrestin2 signaling has emerged as a promising therapeutic target for the management of insulin resistance and related complications. Moreover, recent studies have shown that certain G protein-coupled receptor (GPCR) ligands can modulate β-a
Publikováno v:
Clinical and experimental pharmacologyphysiologyREFERENCES. 47(4)
Insulin resistance and chronic alcoholism are risk factors for renal dysfunction. This study investigated the therapeutic effects of two imidazoline-1 receptor (I1R) agonists on renal dysfunction in rats after chronic, sequential fructose and ethanol
Autor:
Masaki Arioka, Tatsuya Yoshihara, Rasha M. S. M. Mohamed, Toshiyuki Sasaguri, Cheng-Kun Du, Dong Yun Zhan, Sachio Morimoto, Islam A.A.E.-H. Ibrahim, Fumi Takahashi-Yanaga
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 310:H1808-H1815
Glycogen synthase kinase-3β (GSK-3β) plays a central role in both cardiac physiology and pathology. Herein we want to clarify the role of GSK-3β in familial dilated cardiomyopathy. We generated a mouse model carrying a heterozygous knockout mutati
Publikováno v:
Toxicology and Applied Pharmacology. 382:114750
Hepatic ischemia/reperfusion injury (H-IRI) is associated with irreversible liver damage. The current study aimed to investigate the protective effect of carvedilol against H-IRI in high-fructose high-fat diet (HFrHFD)-fed mice and the role of G prot