Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Iskander Aurrekoetxea-Rodríguez"'
Autor:
Erik Oliemuller, Richard Newman, Siu Man Tsang, Shane Foo, Gareth Muirhead, Farzana Noor, Syed Haider, Iskander Aurrekoetxea-Rodríguez, Maria dM Vivanco, Beatrice A Howard
Publikováno v:
eLife, Vol 9 (2020)
SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. Here, we show that SOX11 co
Externí odkaz:
https://doaj.org/article/ba0899cdda394041938c14f10c71925f
Autor:
Giusy Tornillo, Catherine Knowlson, Howard Kendrick, Joe Cooke, Hasan Mirza, Iskander Aurrekoetxea-Rodríguez, Maria d.M. Vivanco, Niamh E. Buckley, Anita Grigoriadis, Matthew J. Smalley
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3674-3692.e10 (2018)
Summary: The SRC-family kinase LYN is highly expressed in triple-negative/basal-like breast cancer (TNBC) and in the cell of origin of these tumors, c-KIT-positive luminal progenitors. Here, we demonstrate LYN is a downstream effector of c-KIT in nor
Externí odkaz:
https://doaj.org/article/ae35eb1c12854be7852afcc692e44cd2
Autor:
Rocio Ortiz, Iskander Aurrekoetxea-Rodríguez, Mathias Rommel, Iban Quintana, Maria dM Vivanco, Jose Luis Toca-Herrera
Publikováno v:
Polymers, Vol 10, Iss 12, p 1337 (2018)
New strategies in regenerative medicine include the implantation of stem cells cultured in bio-resorbable polymeric scaffolds to restore the tissue function and be absorbed by the body after wound healing. This requires the development of appropriate
Externí odkaz:
https://doaj.org/article/4620e1aacff049929c6a29b570af4ac3
Autor:
Iskander Aurrekoetxea-Rodriguez, So Young Lee, Miriam Rábano, Isabel Gris-Cárdenas, Virginia Gamboa-Aldecoa, Irantzu Gorroño, Isabella Ramella-Gal, Connor Parry, Robert M. Kypta, Beñat Artetxe, Juan M. Gutierrez-Zorrilla, Maria dM. Vivanco
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Increased cancer stem cell (CSC) content and SOX2 overexpression are common features in the development of resistance to therapy in hormone-dependent breast cancer, which remains an important clinical challenge. SOX2 has potential
Externí odkaz:
https://doaj.org/article/e9b3f04f62bf488abdfbb2913f741c71
Autor:
Farzana Noor, Syed Haider, Gareth Muirhead, Iskander Aurrekoetxea-Rodríguez, Beatrice A. Howard, Siu Man Tsang, Maria dM Vivanco, Erik Oliemuller, Shane Foo, Richard Newman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f1a3b71e3b43afcfc54da4b886c34a
https://doi.org/10.7554/elife.58374.sa2
https://doi.org/10.7554/elife.58374.sa2
Autor:
Hyunho Yoon, Manuel Picon-Ruiz, Tan A. Ince, Massimo D’Amico, Iskander Aurrekoetxea-Rodríguez, Seth R. Thaller, Cynthia Morata-Tarifa, Vanessa Nunes de Paiva, Rehana Qureshi, Ramya Radhakrishnan, Joyce M. Slingerland, Maria del Mar Vivanco, Marc E. Lippman, Susan B. Kesmodel, Steven E. Rodgers
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cell Metabolism
instname
Cell Metabolism
Many inflammation-associated diseases, including cancers, increase in women after menopause and with obesity. In contrast to anti-inflammatory actions of 17β-estradiol, we find estrone, which dominates after menopause, is pro-inflammatory. In human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ed5baeee5a912146ca762a063fde1e
http://hdl.handle.net/10481/73671
http://hdl.handle.net/10481/73671
Autor:
Robert M. Kypta, Giacomo Domenici, Miriam Rábano, So Young Lee, Beatrice A. Howard, Ignacio Zabalza, Erik Oliemuller, Iskander Aurrekoetxea-Rodríguez, Julia San Millán, Bruno M Simões, Maria dM Vivanco, Valentine Comaills, Jose A. López-Ruiz
Publikováno v:
Oncogene
Domenici, G, Aurrekoetxea-Rodríguez, I, Simões, B M, Rábano, M, Lee, S Y, Millán, J S, Comaills, V, Oliemuller, E, López-Ruiz, J A, Zabalza, I, Howard, B A, Kypta, R M & Vivanco, M DM 2019, ' A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells ', Oncogene . https://doi.org/10.1038/s41388-018-0656-7
Domenici, G, Aurrekoetxea-Rodríguez, I, Simões, B M, Rábano, M, Lee, S Y, Millán, J S, Comaills, V, Oliemuller, E, López-Ruiz, J A, Zabalza, I, Howard, B A, Kypta, R M & Vivanco, M DM 2019, ' A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells ', Oncogene . https://doi.org/10.1038/s41388-018-0656-7
Increased cancer stem cell content during development of resistance to tamoxifen in breast cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling. Here, we show that Sox2 increases and estrogen reduces the express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87af305d93b7bed05e37dc7473701116
https://zenodo.org/record/3606202
https://zenodo.org/record/3606202