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Autor:
Gamze Camlik, Isil Ozakca, Besa Bilakaya, Arif Tanju Ozcelikay, Adrian Joshua Velaro, Siddhanshu Wasnik, Ismail Tuncer Degim
Publikováno v:
Journal of Drug Delivery Science and Technology. 76:103833
Diabetes is still one of the leading causes of death worldwide. According to the World Health Organization, around 1.5 million people worldwide died due to diabetes in 2019. It is estimated that 463 million people are living with diabetes all over th
Autor:
Isil Ozakca, A. Tanju Ozcelikay
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 97:313-319
Systemic infusion of nitric oxide synthase (NOS) inhibitors increases peripheral vascular resistance due to inhibition of endothelial NOS leading to the activation of the arterial baroreceptor mechanisms and inhibition of central sympathetic outflow.
Autor:
Isil Ozakca
Publikováno v:
Journal of Cardiovascular Pharmacology. 73:155-164
The antihypertrophic effect of nebivolol over cardioselective beta-blockers (beta-blockers) is attributed to the activation of cardiac nitric oxide signaling. However, the precise role of nebivolol on hypertrophied cardiomyocytes remains unclear. In
Publikováno v:
Current Drug Targets. 19:602-612
The sympathetic nervous system is one component of the nervous regulatory system of the physiological function of the lower genitourinary tract. Our knowledge on the role of this sympathetic system has advanced during the last decade due to the chara
Publikováno v:
Turkish Journal of Pharmaceutical Sciences, Vol 14, Iss 2, Pp 207-212 (2017)
Turkish Journal of Pharmaceutical Sciences
Turkish Journal of Pharmaceutical Sciences
Vascular tonus is controlled by endothelium-derived relaxing factor (EDRF), endothelium-derived hyperpolarizing factor (EDHF) and endothelium-derived contracting factor (EDCF) under physiological circumstances. In pathological conditions, impairment
Diabetes-induced endothelial damage leads to vascular dysfunction. The current study investigated the effects of short-term (4-week) streptozotocin (STZ)-induced diabetes on responses mediated by endothelium-derived contracting factors (EDCFs) as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677eef2a992b8818f10b465606bc25c5
https://hdl.handle.net/20.500.12645/1775
https://hdl.handle.net/20.500.12645/1775
Publikováno v:
European Journal of Pharmacology. 718:533-543
beta-adrenoceptor-mediated responses are known to be attenuated in diabetic rat hearts, related to decreased receptor sensitivity and density. These impaired responses were improved with insulin in diabetic rats, but not in thyroidectomized diabetic
Publikováno v:
The Journal of Sexual Medicine. 14:e117-e118
Publikováno v:
Ankara Universitesi Eczacilik Fakultesi Dergisi. 38:305-315
Diyabet, iskemik kalp hastaliginin gelisiminde onemli bir rol oynamaktadir ve bu hastaligin uzun donem sonuclarini kotulestirmektedir. Klinik bulgularin aksine diyabetik deneysel hayvan modellerinde kalbin iskemiye karsi duyarliligi ile ilgili sonucl