Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Isil Keskin"'
Autor:
Isil Keskin, Elaheh Ekhtiari Bidhendi, Matthew Marklund, Peter M. Andersen, Thomas Brännström, Stefan L. Marklund, Ulrika Nordström
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract The deposition of aggregated proteins is a common neuropathological denominator for neurodegenerative disorders. Experimental evidence suggests that disease propagation involves prion-like mechanisms that cause the spreading of template-dire
Externí odkaz:
https://doaj.org/article/a0d601b0855a439383f85a8019dea14b
Autor:
Isil Keskin, Elin Forsgren, Dale J Lange, Markus Weber, Anna Birve, Matthis Synofzik, Jonathan D Gilthorpe, Peter M Andersen, Stefan L Marklund
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150133 (2016)
Mutations in superoxide dismutase-1 (SOD1) are a common known cause of amyotrophic lateral sclerosis (ALS). The neurotoxicity of mutant SOD1s is most likely caused by misfolded molecular species, but disease pathogenesis is still not understood. Prop
Externí odkaz:
https://doaj.org/article/511d719618a24f00a8beb534156e6df7
Autor:
Julien H Park, Ulrika Nordström, Konstantinos Tsiakas, Isil Keskin, Christiane Elpers, Manoj Mannil, Raoul Heller, Melinda Nolan, Salam Alburaiky, Per Zetterström, Maja Hempel, Ulrike Schara-Schmidt, Saskia Biskup, Petra Steinacker, Markus Otto, Jochen Weishaupt, Andreas Hahn, René Santer, Thorsten Marquardt, Stefan L Marklund, Peter M Andersen
Superoxide dismutase-1 is a ubiquitously expressed antioxidant enzyme. Mutations in SOD1 can cause amyotrophic lateral sclerosis, probably via a toxic gain-of-function involving protein aggregation and prion-like mechanisms. Recently, homozygosity fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503bd7fd2df67d84f154ec39b0ac77d1
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208224
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208224
Autor:
Thomas Brännström, Matthis Synofzik, Elin Forsgren, Jonathan D. Gilthorpe, Ulrika Nordström, Per Zetterström, Isil Keskin, Stefan L. Marklund, Manuela Lehmann, Dale J. Lange, Peter M. Andersen
Publikováno v:
Acta Neuropathologica
Acta neuropathologica 138(1), 85-101 (2019). doi:10.1007/s00401-019-01986-1
Acta neuropathologica 138(1), 85-101 (2019). doi:10.1007/s00401-019-01986-1
Mutations in superoxide dismutase 1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Disease pathogenesis is linked to destabilization, disorder and aggregation of the SOD1 protein. However, the non-genetic factors that promote disorder and the subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc4c73bc2b56586cb4077b135696acf
https://pubmed.ncbi.nlm.nih.gov/30863976
https://pubmed.ncbi.nlm.nih.gov/30863976
Autor:
Jonathan D. Glass, Peter M. Andersen, Isil Keskin, Reza Rofougaran, Stefan L. Marklund, Anna Birve, Mariusz Berdyński, Torbjörn K. Nilsson, Karin Hjertkvist
Objective: To characterise stabilities in erythrocytes of mutant SOD1 proteins, compare SOD1 enzymatic activities between patients with different genetic causes of ALS and search for underlying causes of deviant SOD1 activities in individuals lacking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660f9f722cd19616eefd3f2877079bed