Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Isidoro, Cobo"'
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103030- (2024)
Summary: Gout is caused by the deposition of monosodium urate crystals (MSUc) in the joints, triggering a unique inflammatory and metabolic response in macrophages. Here, we present a protocol to generate MSUc for in vitro and in vivo studies in mous
Externí odkaz:
https://doaj.org/article/748a4bdf7ee9431d95b55eaac584eca0
Autor:
Isidoro Cobo, Sumit Paliwal, Cristina Bodas, Irene Felipe, Júlia Melià-Alomà, Ariadna Torres, Jaime Martínez-Villarreal, Marina Malumbres, Fernando García, Irene Millán, Natalia del Pozo, Joo-Cheol Park, Ray J. MacDonald, Javier Muñoz, Raúl Méndez, Francisco X. Real
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar differentiation. NFIC binding sites are enriched in NR5A2 ChIP-Seque
Externí odkaz:
https://doaj.org/article/03318fd6a1184623b04fb131e80fac48
Autor:
Isidoro Cobo, Anyan Cheng, Jessica Murillo-Saich, Roxana Coras, Alyssa Torres, Yohei Abe, Addison J. Lana, Johannes Schlachetzki, Ru Liu-Bryan, Robert Terkeltaub, Elsa Sanchez-Lopez, Christopher K. Glass, Monica Guma
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110489- (2022)
Summary: Monosodium urate crystals (MSUc) induce inflammation in vivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that MSUc
Externí odkaz:
https://doaj.org/article/59ac06773fa54dd1820f6bbb11d5a0f0
Autor:
Alyssa Torres, Brian Pedersen, Isidoro Cobo, Rizi Ai, Roxana Coras, Jessica Murillo‐Saich, Gyrid Nygaard, Elsa Sanchez‐Lopez, Anne Murphy, Wei Wang, Gary S. Firestein, Monica Guma
Publikováno v:
Arthritis & rheumatology (Hoboken, N.J.), vol 74, iss 7
Arthritis Rheumatol
Arthritis Rheumatol
ObjectiveSince previous studies indicate that metabolism is altered in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), we undertook this study to determine if changes in the genome-wide chromatin and DNA states in genes associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be20a48b3c1f6bd5d43085eaf31176aa
https://doi.org/10.1002/art.42077
https://doi.org/10.1002/art.42077
Autor:
Kristina Battis, Jazmin B. Florio, Michael Mante, Addison Lana, Isabel Naumann, Carina Gauer, Vera Lambrecht, Simon Julian Müller, Isidoro Cobo, Bethany Fixsen, Ha Yeon Kim, Eliezer Masliah, Christopher K. Glass, Johannes C. M. Schlachetzki, Robert A. Rissman, Jürgen Winkler, Alana Hoffmann
Publikováno v:
J Neurosci
As the CNS-resident macrophages and member of the myeloid lineage, microglia fulfill manifold functions important for brain development and homeostasis. In the context of neurodegenerative diseases, they have been implicated in degenerative and regen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac547b38d97cd5703d9f93188fd9da7
https://pubmed.ncbi.nlm.nih.gov/36333098
https://pubmed.ncbi.nlm.nih.gov/36333098
Autor:
Jaime Martínez-Villarreal, Sumit Paliwal, Joo-Cheol Park, Isidoro Cobo, Javier Munoz, Júlia Melià-Alomà, Irene Millán, Natalia del Pozo, Ariadna Torres, Francisco X. Real, Raymond J. MacDonald, Fernando García
Tissue-specific differentiation is driven by specialized transcriptional networks. Pancreatic acinar cells crucially rely on the PTF1 complex, and on additional transcription factors, to deploy their transcriptional program. Here, we identify NFIC as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc44e74e96f9238ceb2df62b2ee85f32
https://doi.org/10.1101/2021.08.09.455477
https://doi.org/10.1101/2021.08.09.455477
Autor:
Isidoro Cobo, Tiffany N. Tanaka, Kailash Chandra Mangalhara, Addison Lana, Calvin Yeang, Claudia Han, Johannes Schlachetzki, Jean Challcombe, Bethany R. Fixsen, Mashito Sakai, Rick Z. Li, Hannah Fields, Michal Mokry, Randy G. Tsai, Rafael Bejar, Koen Prange, Menno de Winther, Gerald S. Shadel, Christopher K. Glass
Publikováno v:
Immunity, 55(8), 1386-1401.e10. Cell Press
Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of hematopoietic cells and higher risk of cardiovascular disease (CVD). Here, we investigated rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f8e053f041aefd7ae7ef22cd72a238
https://doi.org/10.1016/j.immuni.2022.06.022
https://doi.org/10.1016/j.immuni.2022.06.022
Autor:
Isidoro Cobo, Anyan Cheng, Jessica Murillo-Saich, Roxana Coras, Alyssa Torres, Yohei Abe, Addison J. Lana, Johannes Schlachetzki, Ru Liu-Bryan, Robert Terkeltaub, Elsa Sanchez-Lopez, Christopher K. Glass, Monica Guma
Publikováno v:
Cell Rep
Cell reports, vol 38, iss 10
Cell reports, vol 38, iss 10
Monosodium urate crystals (MSUc) induce inflammation invivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that MSUc alone ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d36a241fb72db9186af3a6daba913b
https://pubmed.ncbi.nlm.nih.gov/35263587
https://pubmed.ncbi.nlm.nih.gov/35263587
Autor:
Monica Guma, Addison J. Lana, Isidoro Cobo, Christopher K. Glass, Alyssa Torres, Ru Liu-Bryan, Elsa Sanchez-Lopez, Jessica D Murillo-Saich, Robert Terkeltaub, Anyan Cheng, Johannes C. M. Schlachetzki, Roxana Coras
Publikováno v:
SSRN Electronic Journal.
The response of macrophages to monosodium urate crystals (MSUc) is incompletely understood partly due to the use of a toll-like receptor (TLR)-induced priming step in cell lines. Yet, MSUc induce inflammation in vivo without prior priming, raising th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c30c5aadba0e0d4c4eb4937b512b39
https://doi.org/10.2139/ssrn.3862792
https://doi.org/10.2139/ssrn.3862792
Autor:
Mar Iglesias, Francisco X. Real, Natalia del Pozo, Miriam Llorente, Isidoro Cobo, Borislav Rusev, Aldo Scarpa, Marta Flández, Claudio Luchini, Caroline S. Verbeke, Rita T. Lawlor
Cystic neoplasms of the pancreas are an increasingly important public health problem. The majority of these lesions are benign but some progress to invasive pancreatic ductal adenocarcinoma (PDAC). There is a dearth of mouse models of these condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65411483eab37060b841056d03f37451
http://hdl.handle.net/11562/1027640
http://hdl.handle.net/11562/1027640