Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Isidora Tošić"'
Autor:
Isidora Tošić, David A. Frank
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g
Externí odkaz:
https://doaj.org/article/bcd24241ef74472dafa6987a998b7cf9
Autor:
Susana P. Egusquiaguirre, Suhu Liu, Isidora Tošić, Kevin Jiang, Sarah R. Walker, Maria Nicolais, Tzuen Yih Saw, Michael Xiang, Katarina Bartel, Erik A. Nelson, David A. Frank
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 1, Pp 47-59 (2020)
The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, thro
Externí odkaz:
https://doaj.org/article/0f1cc32cc4fa4d529fb5cf2e51cc4247
Autor:
Alexandra M. Stevens, Michael Xiang, Lisa N. Heppler, Isidora Tošić, Kevin Jiang, Jaime O. Munoz, Amos S. Gaikwad, Terzah M. Horton, Xin Long, Padmini Narayanan, Elizabeth L. Seashore, Maci C. Terrell, Raushan Rashid, Michael J. Krueger, Alicia E. Mangubat-Medina, Zachary T. Ball, Pavel Sumazin, Sarah R. Walker, Yoshimasa Hamada, Seiichi Oyadomari, Michele S. Redell, David A. Frank
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4215-4227 (2019)
Abstract: Atovaquone, a US Food and Drug Administration–approved antiparasitic drug previously shown to reduce interleukin-6/STAT3 signaling in myeloma cells, is well tolerated, and plasma concentrations of 40 to 80 µM have been achieved with pedi
Externí odkaz:
https://doaj.org/article/4187c59f20f14fd4af323bb29b1514a1
Autor:
Evan C. Chen, Helen Gandler, Isidora Tošić, Geoffrey G. Fell, Ashlee Fiore, Olga Pozdnyakova, Daniel J. DeAngelo, Ilene Galinsky, Marlise R. Luskin, Martha Wadleigh, Eric S. Winer, Rebecca Leonard, Kelsey O'Day, Adrienne de Jonge, Donna Neuberg, A. Thomas Look, Richard M. Stone, David A. Frank, Jacqueline S. Garcia
Publikováno v:
Clinical Cancer Research. 29:878-887
Purpose:Patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) have poor outcomes and require new therapies. In AML, autocrine production of hepatocyte growth factor (HGF) drives MET signaling that promotes myeloblast growth and surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b651c15dd15ad14108c1c5ae348f39b
https://doi.org/10.1158/1078-0432.ccr-22-2540
https://doi.org/10.1158/1078-0432.ccr-22-2540
Autor:
David A. Frank, Paula T. Hammond, Daniel K. Nomura, Daphne A. Haas-Kogan, Alexander R. Ivanov, Douglas S. Richardson, Sharmistha Pal, Elizabeth A. Grossman Moore, Daniel F. Costa, Santiago Correa, Natalie Boehnke, Susana P. Egusquiaguirre, Lisa N. Heppler, Isidora Tošić
Supplementary Table 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570757a18eb92e397eb30a04e0c0163f
https://doi.org/10.1158/1535-7163.22522390
https://doi.org/10.1158/1535-7163.22522390
Autor:
David A. Frank, Paula T. Hammond, Daniel K. Nomura, Daphne A. Haas-Kogan, Alexander R. Ivanov, Douglas S. Richardson, Sharmistha Pal, Elizabeth A. Grossman Moore, Daniel F. Costa, Santiago Correa, Natalie Boehnke, Susana P. Egusquiaguirre, Lisa N. Heppler, Isidora Tošić
Supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007c2e702ed85fd08ab6256dddadb457
https://doi.org/10.1158/1535-7163.22522396.v1
https://doi.org/10.1158/1535-7163.22522396.v1
Autor:
David A. Frank, Paula T. Hammond, Daniel K. Nomura, Daphne A. Haas-Kogan, Alexander R. Ivanov, Douglas S. Richardson, Sharmistha Pal, Elizabeth A. Grossman Moore, Daniel F. Costa, Santiago Correa, Natalie Boehnke, Susana P. Egusquiaguirre, Lisa N. Heppler, Isidora Tošić
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d93cc8fe8b48ad36cf6bfdf37dc330
https://doi.org/10.1158/1535-7163.22522393.v1
https://doi.org/10.1158/1535-7163.22522393.v1
Autor:
David A. Frank, Paula T. Hammond, Daniel K. Nomura, Daphne A. Haas-Kogan, Alexander R. Ivanov, Douglas S. Richardson, Sharmistha Pal, Elizabeth A. Grossman Moore, Daniel F. Costa, Santiago Correa, Natalie Boehnke, Susana P. Egusquiaguirre, Lisa N. Heppler, Isidora Tošić
The oncogenic transcription factor STAT3 is aberrantly activated in 70% of breast cancers, including nearly all triple-negative breast cancers (TNBCs). Because STAT3 is difficult to target directly, we considered whether metabolic changes driven by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46572a7a190d70a16f3177e3e564ab5b
https://doi.org/10.1158/1535-7163.c.6543364.v1
https://doi.org/10.1158/1535-7163.c.6543364.v1
Autor:
Jacqueline S. Garcia, David A. Frank, Richard M. Stone, A. Thomas Look, Donna Neuberg, Adrienne de Jonge, Kelsey O'Day, Rebecca Leonard, Eric S. Winer, Martha Wadleigh, Marlise R. Luskin, Ilene Galinsky, Daniel J. DeAngelo, Olga Pozdnyakova, Ashlee Fiore, Geoffrey G. Fell, Isidora Tošić, Helen Gandler, Evan C. Chen
Survival outcomes for the overall cohort. A, Progression-free survival. B, Overall survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0194804100ba8869c959d958fdf18ea5
https://doi.org/10.1158/1078-0432.22489988.v1
https://doi.org/10.1158/1078-0432.22489988.v1
Autor:
Jacqueline S. Garcia, David A. Frank, Richard M. Stone, A. Thomas Look, Donna Neuberg, Adrienne de Jonge, Kelsey O'Day, Rebecca Leonard, Eric S. Winer, Martha Wadleigh, Marlise R. Luskin, Ilene Galinsky, Daniel J. DeAngelo, Olga Pozdnyakova, Ashlee Fiore, Geoffrey G. Fell, Isidora Tošić, Helen Gandler, Evan C. Chen
Representativeness of Study Participants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ec52834ab87d3fa65e95ef7734db44
https://doi.org/10.1158/1078-0432.22489979.v1
https://doi.org/10.1158/1078-0432.22489979.v1