Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ishwarya Venkata Narayanan"'
Autor:
Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca di Magliano, Kai Ge, Yali Dou, Jiaqi Shi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 643-667 (2022)
Background & Aims: Inactivating mutations of KDM6A, a histone demethylase, were frequently found in pancreatic ductal adenocarcinoma (PDAC). We investigated the role of KDM6A (lysine demethylase 6A) in PDAC development. Methods: We performed a pancre
Externí odkaz:
https://doaj.org/article/30accdb06dbc4b8cb39215d81b9ed199
Autor:
Brian Magnuson, Karan Bedi, Ishwarya Venkata Narayanan, Bartlomiej Bartkowiak, Hailey Blinkiewicz, Michelle T. Paulsen, Arno Greenleaf, Mats Ljungman
Publikováno v:
iScience, Vol 25, Iss 9, Pp 105030- (2022)
Summary: The cyclin-dependent kinase CDK12 has garnered interest as a cancer therapeutic target as DNA damage response genes are particularly suppressed by loss of CDK12 activity. In this study, we assessed the acute effects of CDK12 inhibition on tr
Externí odkaz:
https://doaj.org/article/b01a9fc8f75748d3a89e13357606dce7
Autor:
Shuang Lu, Hong Sun Kim, Yubo Cao, Karan Bedi, Lili Zhao, Ishwarya Venkata Narayanan, Brian Magnuson, Yumei Gu, Jing Yang, Zhujun Yi, Sepideh Babaniamansour, Sargis Shameon, Chang Xu, Michelle T. Paulsen, Ping Qiu, Sivakumar Jeyarajan, Mats Ljungman, Dafydd Thomas, Yali Dou, Howard Crawford, Marina Pasca di Magliano, Kai Ge, Bo Yang, Jiaqi Shi
Publikováno v:
International Journal of Cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf0f78713cd01e5b130915dd4da35759
https://doi.org/10.1002/ijc.34528
https://doi.org/10.1002/ijc.34528
Autor:
Brian Magnuson, Karan Bedi, Mats Ljungman, Thomas E. Wilson, Ishwarya Venkata Narayanan, Michelle T. Paulsen
Publikováno v:
RNA. 27:829-840
Pre-mRNA splicing is carried out by the spliceosome and involves splice site recognition, removal of introns, and ligation of exons. Components of the spliceosome have been shown to interact with the elongating RNA polymerase II (RNAPII), which is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528372ae362bd4392613ba8aac442ba5
https://doi.org/10.1261/rna.078662.120
https://doi.org/10.1261/rna.078662.120
Autor:
Josephine C. Dorsman, Khashayar Roohollahi, Rob M. F. Wolthuis, Daphne E. C. Boer, Johannes C. Walter, Mats Ljungman, Román González-Prieto, Yuichiro Hara, Job de Lange, Tomoo Ogi, Alfred C.O. Vertegaal, Yuka Nakazawa, Yana van der Weegen, Ishwarya Venkata Narayanan, Tycho E. T. Mevissen, Klaas de Lint, Sylvie M. Noordermeer, Diana van den Heuvel, Marta San Martin Alonso, Martijn S. Luijsterburg, Annelotte P. Wondergem, Noud H. M. Klaassen, Janne J. M. van Schie
Publikováno v:
Nature Cell Biology, 23(6), 595-607. Nature Publishing Group
Nature Cell Biology
Nature Cell Biology, 23(6), 595-607. NATURE RESEARCH
van der Weegen, Y, de Lint, K, van den Heuvel, D, Nakazawa, Y, Mevissen, T E T, van Schie, J J M, San Martin Alonso, M, Boer, D E C, González-Prieto, R, Narayanan, I V, Klaassen, N H M, Wondergem, A P, Roohollahi, K, Dorsman, J C, Hara, Y, Vertegaal, A C O, de Lange, J, Walter, J C, Noordermeer, S M, Ljungman, M, Ogi, T, Wolthuis, R M F & Luijsterburg, M S 2021, ' ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation ', Nature Cell Biology, vol. 23, no. 6, pp. 595-607 . https://doi.org/10.1038/s41556-021-00688-9
Nature cell biology, 23(6), 595-607. Nature Publishing Group
Nat Cell Biol
Nature Cell Biology
Nature Cell Biology, 23(6), 595-607. NATURE RESEARCH
van der Weegen, Y, de Lint, K, van den Heuvel, D, Nakazawa, Y, Mevissen, T E T, van Schie, J J M, San Martin Alonso, M, Boer, D E C, González-Prieto, R, Narayanan, I V, Klaassen, N H M, Wondergem, A P, Roohollahi, K, Dorsman, J C, Hara, Y, Vertegaal, A C O, de Lange, J, Walter, J C, Noordermeer, S M, Ljungman, M, Ogi, T, Wolthuis, R M F & Luijsterburg, M S 2021, ' ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation ', Nature Cell Biology, vol. 23, no. 6, pp. 595-607 . https://doi.org/10.1038/s41556-021-00688-9
Nature cell biology, 23(6), 595-607. Nature Publishing Group
Nat Cell Biol
Two side-by-side papers report that the transcription elongation factor ELOF1 drives transcription-coupled repair and prevents replication stress.Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA lesions. DNA dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2732c1379e417cb3de9574f29cff90d4
https://doi.org/10.1038/s41556-021-00688-9
https://doi.org/10.1038/s41556-021-00688-9
Autor:
Dafydd G. Thomas, Howard C. Crawford, Yubo Cao, Michelle T. Paulsen, Shuang Lu, Karan Bedi, Jing Yang, Marina Pasca di Magliano, Ishwarya Venkata Narayanan, Yali Dou, Lili Zhao, Sivakumar Jeyarajan, Krista Chain, Jiaqi Shi, Yumei Gu, Mats Ljungman, Zhujun Yi, Hong Sun Kim
Although KMT2D, also known as MLL2, is known to play an essential role in development, differentiation, and tumor suppression, its role in pancreatic cancer development is not well understood. Here, we discovered a novel signaling axis mediated by KM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cb1f1e540af17980851295eb0af751
Autor:
Ishwarya Venkata Narayanan, Lili Zhao, Sivakumar Jeyarajan, Hong S. Kim, Mats Ljungman, Zhujun Yi, Jiaqi Shi, Shuang Lu, Karan Bedi, Michelle T. Paulsen, Yubo Cao
Publikováno v:
Cancer Research. 79:C28-C28
Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second leading cause of cancer-related death in the United States by 2030. Surgery is the only potential curative treatment for patients with PDAC. However, less than 20% of patients are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a862c92a0b2c9ce3dadcde19b4152a36
https://doi.org/10.1158/1538-7445.panca19-c28
https://doi.org/10.1158/1538-7445.panca19-c28
Autor:
Michelle T. Paulsen, Artur Veloso, Emily A. Ljungman, Sofia Francia, Brian Magnuson, Mats Ljungman, Karan Bedi, Fabrizio d'Adda di Fagagna, Ishwarya Venkata Narayanan, Thomas E. Wilson, Nathan Berg
Publikováno v:
Scientific Reports
In response to ionizing radiation (IR), cells activate a DNA damage response (DDR) pathway to re-program gene expression. Previous studies using total cellular RNA analyses have shown that the stress kinase ATM and the transcription factor p53 are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14caf876c05f1eacd4a10fbfca4544f4