Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Ishwar S. Singh"'
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118010 (2015)
Sepsis, a devastating and often lethal complication of severe infection, is characterized by fever and dysregulated inflammation. While infections activate the inflammatory response in part through Toll-like receptors (TLRs), fever can partially acti
Externí odkaz:
https://doaj.org/article/5cd12cd0dce74d5ca73dd8a549401d99
Autor:
James H. Shelhamer, Rachel Greenberg Scheraga, Jeffrey D. Hasday, Ratnakar Potla, Irina G. Luzina, Ashish Nagarsekar, Carolea Logun, Nevins W. Todd, Ishwar S. Singh, Junfeng Sun, Rongman Cai, Sergei P. Atamas, Christopher R. Thompson, Mohan E. Tulapurkar, Mark J. Cowan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 311:L941-L955
We previously showed that coincident exposure to heat shock (HS; 42°C for 2 h) and TNF-α synergistically induces apoptosis in mouse lung epithelium. We extended this work by analyzing HS effects on human lung epithelial responses to clinically rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eca292a472b77a4203949e49d4a0018
https://doi.org/10.1152/ajplung.00262.2016
https://doi.org/10.1152/ajplung.00262.2016
Autor:
Tapas K. Makar, David Trisler, Ishwar S. Singh, Christopher T. Bever, Vamshi K.C. Nimmagadda, Fahad Mubariz, Susan I.V. Judge, Kristal Lam
Publikováno v:
Journal of Neuroimmunology. 292:9-20
7,8-Dihydroxyflavone (DHF), is a recently described TrkB agonist that readily crosses the blood brain barrier. We treated C57Bl/6 mice with MOG--induced EAE daily with DHF starting on the day of disease induction. Clinical severity of impairment was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa140ef57b32a7124be47f13d0170d4
https://doi.org/10.1016/j.jneuroim.2016.01.002
https://doi.org/10.1016/j.jneuroim.2016.01.002
Autor:
Mohan E. Tulapurkar, Ishwar S. Singh, Irina G. Luzina, Sergei P. Atamas, Ratnakar Potla, Jeffrey D. Hasday
Publikováno v:
Int J Hyperthermia
BACKGROUND: As environmental and body temperatures vary, lung epithelial cells experience temperatures significantly different from normal core temperature. Our previous studies in human lung epithelium showed that: (1) heat shock accelerates wound h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd11fe134d6fae870b3c162f97678902
https://europepmc.org/articles/PMC7328721/
https://europepmc.org/articles/PMC7328721/
Autor:
Jeffrey D. Hasday, Ishwar S. Singh
Publikováno v:
International Journal of Hyperthermia. 29:423-435
The heat shock response is a highly conserved primitive response that is essential for survival against a wide range of stresses, including extremes of temperature. Fever is a more recently evolved response, during which organisms raise their core bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657c2739343cbe6679bf095dd8eb2928
https://doi.org/10.3109/02656736.2013.808766
https://doi.org/10.3109/02656736.2013.808766
Publikováno v:
International Journal of Hyperthermia. 28:747-755
Chronic heat exposure in mice has cellular and physiological effects that improve thermal tolerance [1], but also modifies innate immune responses with potential adverse consequences [2]. While male and female mice are known to respond differently to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2800d888c9027f1b175dc51d5125e0a
https://doi.org/10.3109/02656736.2012.734425
https://doi.org/10.3109/02656736.2012.734425
Autor:
Paul Shapiro, Ishwar S. Singh, Adam C. Puche, Eid Almutairy, Jeffrey D. Hasday, Mohan E. Tulapurkar, Ju-Ren He, Nirav Shah
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 46:807-814
Acute respiratory distress syndrome (ARDS) is a neutrophil (polymorphonuclear leukocyte; PMN)–driven lung injury that is associated with fever and heat-stroke, and involves approximately 40% mortality. In murine models of acute lung injury (ALI), f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9622e2328dd4c9e6a686087674016458
https://doi.org/10.1165/rcmb.2011-0378oc
https://doi.org/10.1165/rcmb.2011-0378oc
Publikováno v:
International Journal of Hyperthermia. 27:717-725
The effects of heat, especially long-term heat exposure, are complex and incompletely understood and few studies have analysed the immunological consequences of such exposures. In the present study we analysed how long-term hyperthermia modified the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edb5dfac0db70c178ada78ba1c70cdb
https://doi.org/10.3109/02656736.2011.601528
https://doi.org/10.3109/02656736.2011.601528
Autor:
Mohan E. Tulapurkar, Tapan Maity, Michael Henry, Jeffrey D. Hasday, Ishwar S. Singh, Nirav Shah
Publikováno v:
Cytokine. 54:61-67
The heat shock (HS) response, a phylogenetically conserved ubiquitous response to stress, is generally characterized by the induced expression of heat shock protein (HSP) genes. Our earlier studies showed that the stress-activated transcription facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2caf6e9f9d42d76d536f60c6ac962d6
https://doi.org/10.1016/j.cyto.2010.12.017
https://doi.org/10.1016/j.cyto.2010.12.017
Autor:
Mohan E. Tulapurkar, Nirav Shah, Jeffrey D. Hasday, Mark J. Cowan, Ishwar S. Singh, James H. Shelhamer
Publikováno v:
Prostaglandins & Other Lipid Mediators. 93:1-7
The heat shock (HS) response is an important cytoprotective response comprising the expression of heat shock proteins (HSPs) and orchestrated by the heat/stress-induced transcription factor, heat shock factor-1 (HSF-1). Previous studies suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a01ac0dfed367625d80bf63b58c6fb2
https://doi.org/10.1016/j.prostaglandins.2010.03.006
https://doi.org/10.1016/j.prostaglandins.2010.03.006