Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ishita Parikh"'
Autor:
Juan Maldonado Weng, Ishita Parikh, Ankur Naqib, Jason York, Stefan J. Green, Steven Estus, Mary Jo LaDu
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background Alzheimer’s disease (AD) is a fatal neurodegenerative disease. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 15-fold compared to the common APOE3. Importantly, female (♀) APOE4 carriers have a greater
Externí odkaz:
https://doaj.org/article/d8eeb3b3e50d46efa93f3f0cf1e2e7f6
Autor:
Ai-Ling Lin, Ishita Parikh, Lucille M. Yanckello, Renee S. White, Anika M.S. Hartz, Chase E. Taylor, Scott D. McCulloch, Scott W. Thalman, Mengfan Xia, Katie McCarty, Margo Ubele, Elizabeth Head, Fahmeed Hyder, Basavaraju G. Sanganahalli
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104834- (2020)
The ε4 allele of Apolipoprotein (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), the most common form of dementia. Cognitively normal APOE4 carriers have developed amyloid beta (Aβ) plaques and cerebrovascular, metabolic a
Externí odkaz:
https://doaj.org/article/0b663fcc0f7140b68ce3f5588b29328d
Autor:
Jared D Hoffman, Lucille M Yanckello, George Chlipala, Tyler C Hammond, Scott D McCulloch, Ishita Parikh, Sydney Sun, Josh M Morganti, Stefan J Green, Ai-Ling Lin
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221828 (2019)
The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunct
Externí odkaz:
https://doaj.org/article/f7f2ee8277c149b28149183347404334
Autor:
Jennifer Lee, Lucille M. Yanckello, David Ma, Jared D. Hoffman, Ishita Parikh, Scott Thalman, Bjoern Bauer, Anika M. S. Hartz, Fahmeed Hyder, Ai-Ling Lin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
The mechanistic target of rapamycin (mTOR) is a nutrient sensor of eukaryotic cells. Inhibition of mechanistic mTOR signaling can increase life and health span in various species via interventions that include rapamycin and caloric restriction (CR).
Externí odkaz:
https://doaj.org/article/8a74dc9b9c6340bfb5d737225ecefe53
Autor:
Jared D. Hoffman, Ishita Parikh, Stefan J. Green, George Chlipala, Robert P. Mohney, Mignon Keaton, Bjoern Bauer, Anika M. S. Hartz, Ai-Ling Lin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer’s disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence shows that reduced brain met
Externí odkaz:
https://doaj.org/article/bb227085d55c400fbb159dda0c3c7eff
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91242 (2014)
Novel Alzheimer's disease (AD) risk factors have been identified by genome-wide association studies. Elucidating the mechanism underlying these factors is critical to the validation process and, by identifying rate-limiting steps in AD risk, may yiel
Externí odkaz:
https://doaj.org/article/539952d6005c419a81a4841fa17cbc73
Autor:
Margo F. Ubele, Fahmeed Hyder, Elizabeth Head, Anika M.S. Hartz, Renee S. White, Ishita Parikh, Scott McCulloch, Basavaraju G. Sanganahalli, Katie McCarty, Chase E. Taylor, Mengfan Xia, Ai-Ling Lin, Lucille M. Yanckello, Scott Thalman
Publikováno v:
Neurobiology of Disease, Vol 139, Iss, Pp 104834-(2020)
Neurobiol Dis
Neurobiol Dis
The ε4 allele of Apolipoprotein (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), the most common form of dementia. Cognitively normal APOE4 carriers have developed amyloid beta (Aβ) plaques and cerebrovascular, metabolic a
Autor:
Anika M.S. Hartz, M. Paul Murphy, Björn Bauer, David Ma, Amy C Wang, George E. Chlipala, Stefan J. Green, Ishita Parikh, Brent S. Sokola, Jared D. Hoffman, Ai-Ling Lin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB) function, plays a major role in determining cognitive capability. Recent studies suggest that neurovascular integrity could be regulated by the gut microbiome.
Publikováno v:
Current Nutrition Reports. 6:41-48
Non-invasive neuroimaging methods have been developed as powerful tools for identifying in vivo brain functions for studies in humans and animals. Here, we review the imaging biomarkers that are being used to determine the changes within brain metabo
Autor:
Anika M.S. Hartz, Ishita Parikh, Björn Bauer, Jared D. Hoffman, Ralf G. Rempe, Ai-Ling Lin, Rachel Armstrong, Kai-Hsiang Chuang, Yu Zhong, Janet Guo
Publikováno v:
Aging (Albany NY)
Neurovascular integrity plays an important role in protecting cognitive and mental health in aging. Lifestyle interventions that sustain neurovascular integrity may thus be critical on preserving brain functions in aging and reducing the risk for age