Výsledky vyhledávání - "Ishina Balwani"

CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function

Publikováno v: Science translational medicine 14 (2022). doi:10.1126/scitranslmed.abg8027
info:cnr-pdr/source/autori:Ruggiero, Eliana; Carnevale, Erica; Prodeus, Aaron; Magnani, Zulma Irene; Camisa, Barbara; Merelli, Ivan; Politano, Claudia; Stasi, Lorena; Potenza, Alessia; Cianciotti, Beatrice Claudia; Manfredi, Francesco; Di Bono, Mattia; Vago, Luca; Tassara, Michela; Mastaglio, Sara; Ponzoni, Maurilio; Sanvito, Francesca; Liu, Dai; Balwani, Ishina; Galli, Rossella; Genua, Marco; Ostuni, Renato; Doglio, Matteo; O'Connell, Daniel; Dutta, Ivy; Yazinski, Stephanie Ann; McKee, Mark; Arredouani, Mohamed Simo; Schultes, Birgit; Ciceri, Fabio; Bonini, Chiara/titolo:CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function/doi:10.1126%2Fscitranslmed.abg8027/rivista:Science translational medicine/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:14

T cell receptor (TCR)–based therapy has the potential to induce durable clinical responses in patients with cancer by targeting intracellular tumor antigens with high sensitivity and by promoting T cell survival. However, the need for TCRs specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721e152e0f9ed32a72141cc049879e3a
https://pubmed.ncbi.nlm.nih.gov/35138911

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173 An in vivo CRISPR/Cas9 screening platform to identify T cell enhancing edits in distinct solid tumor microenvironments

Autor: Birgit Schultes, Troy Luster, Daniel O’Connell, Jeffrey Jones, Erica Del Aguila, Nishit Patel, Srijani Sridhar, Jingwei Sun, Nachiket Shevale, Amy Melissa Becker, Ishina Balwani, Reynald Lescarbeau

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Background Chimeric antigen receptor (CAR)-based T cell therapy and other forms of adoptive cell therapies (ACTs) have shown remarkable success in the treatment of hematologic malignancies; however, reports of clinical activity in solid tumors are li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddac4dff9b778874c5f093f4ac38275
https://doi.org/10.1136/jitc-2020-sitc2020.0173

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Dual TLR agonist nanodiscs as a strong adjuvant system for vaccines and immunotherapy

Autor: Lukasz J. Ochyl, Minzhi Yu, Ishina Balwani, Alireza Hassani Najafabadi, Yao Xu, Rui Kuai, Xiaoqi Sun, Lindsay Scheetz, Wenmin Yuan, Anna Schwendeman, James J. Moon

Publikováno v: Journal of Controlled Release. 282:131-139

Recent studies have shown that certain combinations of Toll-like receptor (TLR) agonists can induce synergistic immune activation. However, it remains challenging to achieve such robust responses in vivo in a manner that is effective, facile, and ame

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728705ea2b9085b909a504e4a523a474
https://doi.org/10.1016/j.jconrel.2018.04.041

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A Novel Strategy for Off-the-Shelf T Cell Therapy Which Evades Allogeneic T Cell and NK Cell Rejection

Autor: Utsav Jetley, Daniel O′Connell, Reynald Lescarbeau, Surbhi Goel, Birgit Schultes, Marie Keenan, Palak Sharma, Simo M Arredouani, Priya Venkatesan, John Averill, Yiyang Tan, Ishina Balwani, Matthew Roy, Utkarsha Ranade, Ivy Dutta, Yong Zhang, Dai Liu, Aaron Prodeus

Publikováno v: Blood. 138:1711-1711

Introduction. Despite the success of autologous chimeric antigen receptor (CAR)-T cells, barriers to a more widespread use of this potentially curative therapy include manufacturing failures and the high cost of individualized production. There is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5621d94c5b5008ec12b414b2ef8b9d8
https://doi.org/10.1182/blood-2021-152999

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Role of phytase producing microorganisms towards agricultural sustainability

Autor: Smriti Gaur, Ishina Balwani, Kashyapi Chakravarty

Publikováno v: Biocatalysis and Agricultural Biotechnology. 12:23-29

Focusing towards sustainable and environment friendly agricultural techniques, phytase enzymes have proved to be beneficial in many aspects. It is a group of enzymes, which are capable of degrading phosphate containing organic molecules, henceforth r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d49a40ee2eef32e0a8530d8bd1524d1
https://doi.org/10.1016/j.bcab.2017.08.010

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NTLA5001, a T Cell Product Candidate with CRISPR-Based Targeted Insertion of a High-Avidity, Natural, WT1-Specific TCR, Shows Efficacy in In Vivo Models of AML and ALL

Autor: Aaron Prodeus, Amy M. Becker, Laura Sepp-Lorenzino, Maxwell Foisey, Birgit Schultes, Mark D. McKee, Simo M Arredouani, Eliana Ruggiero, Chiara Bonini, Ishina Balwani, Fabio Ciceri, Ivy Dutta, Qingzhan Zhang, Dai Liu

Publikováno v: Blood. 136:32-33

Adoptive cell therapy using T cells expressing transgenic (tg) tumor antigen-targeting T cell receptors (TCRs) has become an attractive modality to treat hematological and solid cancers due to a broader array of accessible targets relative to CAR-T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ac5926d3af5e83428284188fe3ade30
https://doi.org/10.1182/blood-2020-143119

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Abstract 5574: In vivo model development for immune cell-based therapeutics

Autor: Jeffrey Jones, Christopher Rudulier, Minasri Borah, Utsav Jetley, Terina Martinez, Vandhana Ragothaman, Marie Keenan, Yong Zhang, Yuko Miki, Birgit Schultes, Elizabeth McMichael, Amanda Frain, Ishina Balwani, Priya Pajanirassa, Troy A. Luster, Nicole Ganci

Publikováno v: Cancer Research. 80:5574-5574

The implementation of various mouse models is critical to asses safety, efficacy, and short- and long-term persistence of therapeutic modalities, especially for cell-based therapies. To increase our repertoire of viable humanized murine models, we de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0005f7f296937d96a89b5ed64c7ca1ca
https://doi.org/10.1158/1538-7445.am2020-5574

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