New insights into cancer pathology learned from the dynamics of cancer-associated fibroblasts.

Autor: Ishii G; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.; Division of Innovative Pathology and Laboratory Medicine, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.; Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

Publikováno v: Pathology international [Pathol Int] 2024 Sep; Vol. 74 (9), pp. 493-507. Date of Electronic Publication: 2024 Jun 25.

Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development.

Autor: Takano Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.; Pharmaceutical Science Department, Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan., Suzuki J; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.; Department of General Thoracic Surgery, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan., Nomura K; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan., Fujii G; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Zenkoh J; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Kawai H; Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Kuze Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Kashima Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Nagasawa S; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Nakamura Y; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Kojima M; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Tsuchihara K; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Seki M; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Kanai A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Matsubara D; Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Kohno T; Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Noguchi M; Department of Diagnostic Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Center for Clinical and Translational Science, Shonan Kamakura General Hospital, Kamakura, Kanagawa, Japan., Nakaya A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan., Tsuboi M; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan., Ishii G; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan., Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan. ysuzuki@edu.k.u-tokyo.ac.jp., Suzuki A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan. asuzuki@edu.k.u-tokyo.ac.jp.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 06; Vol. 15 (1), pp. 10637. Date of Electronic Publication: 2024 Dec 06.

The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine.

Autor: Hashimoto T; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Nakamura Y; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Fujisawa T; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.; Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Imai M; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan., Shibuki T; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan., Iida N; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan., Ozaki H; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan., Nonomura N; Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan., Morizane C; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan., Iwata H; Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Okano S; Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Yamagami W; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Yamazaki N; Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, Japan., Kadowaki S; Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Taniguchi H; Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Ueno M; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Boku S; Cancer Treatment Center, Kansai Medical University Hospital, Osaka, Japan., Oki E; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Komatsu Y; Department of Cancer Center, Hokkaido University Hospital, Sapporo, Japan., Yuki S; Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan., Makiyama A; Cancer Center, Gifu University Hospital, Gifu, Japan.; Center for One Medicine Innovative Translational Research, Gifu University, Gifu, Japan., Otsuka T; Department of Medical Oncology, Osaka International Cancer Institute Osaka Prefectural Hospital Organization, Osaka, Japan., Hara H; Department of Gastroenterology, Saitama Cancer Center, Saitama, Japan., Okano N; Department of Medical Oncology, Kyorin University Faculty of Medicine, Tokyo, Japan., Nishina T; Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan., Sakamoto Y; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan., Miki I; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan., Kobayashi S; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Japan., Yuda J; Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan., Kageyama SI; Department of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Nagamine M; TR Sample Management Office, National Cancer Center Hospital East, Kashiwa, Japan., Sakashita S; TR Sample Management Office, National Cancer Center Hospital East, Kashiwa, Japan., Sakamoto N; TR Sample Management Office, National Cancer Center Hospital East, Kashiwa, Japan., Yamashita R; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan., Koga Y; Division of Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Bando H; Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Ishii G; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan., Kuwata T; Department of Genetic Medicine and Services, National Cancer Center Hospital East, Kashiwa, Japan., Park WY; GxD Inc., Kashiwa, Japan.; Samsung Genome Institute, Samsung Medical Center, Seoul, Korea., Ohtsu A; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Yoshino T; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Nov 01; Vol. 14 (11), pp. 2243-2261.

Clinical Significance of a Prospective Large Genomic Screening for SCLC: The Genetic Classification and a Biomarker-Driven Phase 2 Trial of Gedatolisib.

Autor: Umemura S; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Udagawa H; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Ikeda T; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Murakami H; Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan., Daga H; Department of Medical Oncology, Osaka City General Hospital, Osaka, Japan., Toyozawa R; Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan., Kozuki T; Department of Thoracic Oncology and Medicine, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan., Sakakibara-Konishi J; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan., Ohe Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan., Morise M; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kato T; Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan., Shingyoji M; Division of Respirology, Chiba Cancer Center, Chiba, Japan., Hara S; Department of Respiratory Medicine, Itami City Hospital, Itami, Japan., Furuya N; Division of Respiratory Medicine, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan., Teranishi S; Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan., Takata S; Department of Respiratory Medicine, Kyorin University School of Medicine, Mitaka, Japan., Miyamoto S; Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan., Nakachi I; Department of Internal Medicine, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan., Wakabayashi M; Clinical Research Support Office, National Cancer Center Hospital East, Chiba, Japan., Nomura S; Clinical Research Support Office, National Cancer Center Hospital East, Chiba, Japan; Department of Biostatistics and Bioinformatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Sato A; Clinical Research Support Office, National Cancer Center Hospital East, Chiba, Japan., Ishii G; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan., Tsuchihara K; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan., Sugiyama E; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Kirita K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Sakai T; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Shibata Y; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Izumi H; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Nosaki K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Zenke Y; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Matsumoto S; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Yoh K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Niho S; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Goto K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan. Electronic address: kgoto@east.ncc.go.jp.

Publikováno v: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.

Assessment of Elastic Laminal Invasion Contributes to an Objective pT3 Subclassification in Colon Cancer.

Autor: Kojima M; Division of Pathology, Exploratory Oncology, & Clinical Trial Center (EPOC), National Cancer Center., Yokota M; Departments of Surgery., Yanagisawa N; Clinical Research and Trial Center, Juntendo University School of Medicine., Kitamura S; Clinical Research and Trial Center, Juntendo University School of Medicine., Amemiya K; Department of Coloproctological Surgery, Juntendo University Faculty of Medicine., Kawano S; Department of Coloproctological Surgery, Juntendo University Faculty of Medicine., Tsukada Y; Departments of Colorectal Surgery., Sakuyama N; Department of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo., Nagayasu K; Department of Surgery, Tobu Chiiki Hospital, Metropolitan Health and Medical Treatment Corporation., Hashimoto T; Departments of Pathology and Clinical Laboratories., Nakashima K; Department of Diagnostic Pathology, Kurume University Hospital., Jiang K; Department of Pathology, Moffitt Cancer Center, Tampa, FL., Kanemitsu Y; Colorectal Surgery, National Cancer Center Hospital., Fujita F; Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka Prefecture, Japan., Akiba J; Department of Diagnostic Pathology, Kurume University Hospital., Notohara K; Anatomic Pathology, Kurashiki Central Hospital, Kurashiki, Okayama Prefecture., Itakura J; Anatomic Pathology, Kurashiki Central Hospital, Kurashiki, Okayama Prefecture., Sekine S; Departments of Pathology and Clinical Laboratories., Sakashita S; Division of Pathology, Exploratory Oncology, & Clinical Trial Center (EPOC), National Cancer Center., Sakamoto N; Division of Pathology, Exploratory Oncology, & Clinical Trial Center (EPOC), National Cancer Center., Ishikawa S; Division of Pathology, Exploratory Oncology, & Clinical Trial Center (EPOC), National Cancer Center., Nakanishi Y; Department of Pathology, Moffitt Cancer Center, Tampa, FL., Yao T; Department of Human Pathology, Graduate School of Medicine, Juntendo University, Tokyo., Liang WY; Department of Pathology and Laboratory Medicine, Veterans General Hospital-Taipei, Taipei, Republic of China., Lauwers GY; Department of Pathology, Moffitt Cancer Center, Tampa, FL., Ito M; Departments of Colorectal Surgery., Sakamoto K; Department of Coloproctological Surgery, Juntendo University Faculty of Medicine., Ishii G; Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Chiba Prefecture., Ochiai A; Division of Pathology, Exploratory Oncology, & Clinical Trial Center (EPOC), National Cancer Center.

Publikováno v: The American journal of surgical pathology [Am J Surg Pathol] 2023 Oct 01; Vol. 47 (10), pp. 1122-1133. Date of Electronic Publication: 2023 Jun 30.