SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma.

Autor: Ishida CT; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Myers SL; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kubota CS; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Shao W; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland., McGuire MR; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Liu C; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ewachiw TE; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mukhopadhyay D; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ke S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wang H; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Rasheed ZA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Anders RA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Espenshade PJ; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Giovanis Institute for Translational Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Sep 01; Vol. 4 (9), pp. 2539-2552.

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma.

Autor: Ishida CT, Myers SL, Shao W, McGuire MR, Liu C, Kubota CS, Ewachiw TE, Mukhopadhyay D, Ke S, Wang H, Rasheed ZA, Anders RA, Espenshade PJ

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 08. Date of Electronic Publication: 2024 Feb 08.

Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl-xL inhibition.

Autor: Nguyen TTT; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA., Ishida CT; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA., Shang E; Department of Biological Sciences, Bronx Community College, City University of New York, Bronx, NY, USA., Shu C; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA., Torrini C; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA., Zhang Y; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA., Bianchetti E; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA., Sanchez-Quintero MJ; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Kleiner G; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Quinzii CM; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Westhoff MA; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Karpel-Massler G; Department of Neurosurgery, Ulm University Medical Center, Ulm, Germany., Canoll P; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA., Siegelin MD; Department of Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2019 Oct; Vol. 11 (10), pp. e10769. Date of Electronic Publication: 2019 Aug 29.

Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.

Autor: Ishida CT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Zhang Y; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Bianchetti E; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Shu C; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Nguyen TTT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Kleiner G; Department of Neurology, Columbia University Medical Center, New York, New York., Sanchez-Quintero MJ; Department of Neurology, Columbia University Medical Center, New York, New York., Quinzii CM; Department of Neurology, Columbia University Medical Center, New York, New York., Westhoff MA; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Karpel-Massler G; Department of Neurosurgery, Ulm University Medical Center, Ulm, Germany., Prabhu VV; Oncoceutics, Inc., Philadelphia, Pennsylvania., Allen JE; Oncoceutics, Inc., Philadelphia, Pennsylvania., Siegelin MD; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York. ms4169@cumc.columbia.edu.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Nov 01; Vol. 24 (21), pp. 5392-5406. Date of Electronic Publication: 2018 Jul 23.

Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma.

Autor: Zhang Y; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Ishida CT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Ishida W; Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland., Lo SL; Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland., Zhao J; Department of Biomedical Informatics, Columbia University, New York, New York., Shu C; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Bianchetti E; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Kleiner G; Department of Neurology, H. Houston Merritt Neuromuscular Research Center, Columbia University Medical Center, New York, New York., Sanchez-Quintero MJ; Department of Neurology, H. Houston Merritt Neuromuscular Research Center, Columbia University Medical Center, New York, New York., Quinzii CM; Department of Neurology, H. Houston Merritt Neuromuscular Research Center, Columbia University Medical Center, New York, New York., Westhoff MA; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Karpel-Massler G; Department of Neurosurgery, Ulm University Medical Center, Ulm, Germany., Canoll P; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York., Siegelin MD; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York. ms4169@cumc.columbia.edu.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Aug 15; Vol. 24 (16), pp. 3941-3954. Date of Electronic Publication: 2018 May 15.