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Kinetic Stability of Long-Lived Human Lens γ-Crystallins and Their Isolated Double Greek Key Domains
Autor:
Ishara A. Mills-Henry, Eugene Serebryany, Jonathan King, Shannon L. Thol, Melissa S. Kosinski-Collins
Publikováno v:
Biophys J
The γ-crystallins of the eye lens nucleus are among the longest-lived proteins in the human body. Synthesized in utero, they must remain folded and soluble throughout adulthood to maintain lens transparency and avoid cataracts. γD- and γS-crystall