Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ishan Chakravarty"'
Autor:
Ying Zhang, Raghava N. Sriramaneni, Paul A. Clark, Justin C. Jagodinsky, Mingzhou Ye, Wonjong Jin, Yuyuan Wang, Amber Bates, Caroline P. Kerr, Trang Le, Raad Allawi, Xiuxiu Wang, Ruosen Xie, Thomas C. Havighurst, Ishan Chakravarty, Alexander L. Rakhmilevich, Kathleen A. O’Leary, Linda A. Schuler, Paul M. Sondel, Kyungmann Kim, Shaoqin Gong, Zachary S. Morris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment fo
Externí odkaz:
https://doaj.org/article/5182a8b990d848bdaa69308ac2077051
Autor:
Zachary S Morris, KyungMann Kim, Paul M Sondel, Paul A Clark, Raghava N Sriramaneni, Won Jong Jin, Justin C Jagodinsky, Amber M Bates, Ishan Chakravarty, Thomas C Havighurst, Erin J Nystuen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background Radiation therapy (RT) has been demonstrated to generate an in situ vaccination (ISV) effect in murine models and in patients with cancer; however, this has not routinely translated into enhanced clinical response to immune checkpoint inhi
Externí odkaz:
https://doaj.org/article/4fb8533924bd4b09b31e36bf63136f4d
Autor:
Raghava N Sriramaneni, Justin C Jagodinsky, Abigail A Jaquish, Bryce R Anderson, Trang Le, Jonathan A Lubin, Ishan Chakravarty, Ian S Arthur, Clinton M Heinze, Kelsey A Klar, John S Kuo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immune checkpoint inhibition (ICI) alone is not efficacious for a large number of patients with melanoma brain metastases. We previously established an in situ vaccination (ISV) regimen combining radiation and immunocytokine to enhance res
Externí odkaz:
https://doaj.org/article/5403053984ba479cad7610cc87ac2b46
Autor:
Justin C Jagodinsky, Amber M Bates, Paul A Clark, Raghava N Sriramaneni, Thomas C Havighurst, Ishan Chakravarty, Erin J Nystuen, KyungMann Kim, Paul M Sondel, Won Jong Jin, Zachary S Morris
Publikováno v:
Journal for immunotherapy of cancer. 10(10)
BackgroundRadiation therapy (RT) has been demonstrated to generate an in situ vaccination (ISV) effect in murine models and in patients with cancer; however, this has not routinely translated into enhanced clinical response to immune checkpoint inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210bc5f324f912410012bec30f7f991f
https://pubmed.ncbi.nlm.nih.gov/36192087
https://pubmed.ncbi.nlm.nih.gov/36192087
Autor:
Zachary S. Morris, Trang T. Le, Ian Marsh, Won Jong Jin, Peter M. Carlson, Raghava N. Sriramaneni, Jonathan W. Engle, Luke M. Zangl, Justin C. Jagodinsky, Amber M. Bates, Todd E. Barnhart, Joseph Grudzinski, Ian S. Arthur, Ravi Patel, Ryan J. Brown, Erin J. Nystuen, Reinier Hernandez, Ishan Chakravarty, Jamey P. Weichert, KyungMann Kim, Bryan Bednarz, Eduardo Aluicio-Sarduy, Caroline Kerr, Sarah E. Emma
Publikováno v:
Theranostics
Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 interferon (IFN1) response mediated via stimulator of interferon genes (STING),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daed47a443e514231d36d2cbac68e4e3
https://doi.org/10.7150/thno.54881
https://doi.org/10.7150/thno.54881
Autor:
Ying Zhang, Raghava N. Sriramaneni, Paul A. Clark, Justin C. Jagodinsky, Mingzhou Ye, Wonjong Jin, Yuyuan Wang, Amber Bates, Caroline P. Kerr, Trang Le, Raad Allawi, Xiuxiu Wang, Ruosen Xie, Thomas C. Havighurst, Ishan Chakravarty, Alexander L. Rakhmilevich, Kathleen A. O’Leary, Linda A. Schuler, Paul M. Sondel, Kyungmann Kim, Shaoqin Gong, Zachary S. Morris
Publikováno v:
Nature communications. 13(1)
Radiation therapy (RT) activates an in situ vaccine effect when combined with immune checkpoint blockade (ICB), yet this effect may be limited because RT does not fully optimize tumor antigen presentation or fully overcome suppressive mechanisms in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6304f23d40bc18d72747d29f690314e
https://pubmed.ncbi.nlm.nih.gov/35999216
https://pubmed.ncbi.nlm.nih.gov/35999216
Autor:
Paul A. Clark, Joseph Grudzinski, Ian S. Arthur, Zachary S. Morris, Trang T. Le, Jamey P. Weichert, Won Jong Jin, Bryce R. Anderson, Bryan Bednarz, Eduardo Aluicio-Sarduy, Jonathan W. Engle, Raghava N. Sriramaneni, Todd E. Barnhart, Ian Marsh, Amber M. Bates, Ishan Chakravarty, Reinier Hernandez, Justin C. Jagodinsky, KyungMann Kim, Justin J. Jeffery
Publikováno v:
Radiat Res
Brain metastases develop in over 60% of advanced melanoma patients and negatively impact quality of life and prognosis. In a murine melanoma model, we previously showed that an in situ vaccination (ISV) regimen, combining radiation treatment and intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47355ee700ebd2f30023ccf97fe81cb
https://doi.org/10.1667/rade-20-00237.1
https://doi.org/10.1667/rade-20-00237.1
Autor:
Zachary S. Morris, Paul A. Clark, Ian S. Arthur, Won Jong Jin, Kelsey A Klar, Jonathan A. Lubin, Jasdeep S. Kler, Amber M. Bates, John S. Kuo, Ishan Chakravarty, Bryce R. Anderson, Raghava N. Sriramaneni, Emily I. Guy, Justin C. Jagodinsky, Abigail A Jaquish, Trang T. Le, Clinton M. Heinze, Peter M. Carlson, Kyung Mann Kim
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundImmune checkpoint inhibition (ICI) alone is not efficacious for a large number of patients with melanoma brain metastases. We previously established an in situ vaccination (ISV) regimen combining radiation and immunocytokine to enhance resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d372b4357eddd899b143a36b2b6a90
https://jitc.bmj.com/content/8/2/e000809.full
https://jitc.bmj.com/content/8/2/e000809.full
Autor:
Ryan J. Brown, Ian S. Arthur, Erin J. Nystuen, Ravi Patel, Luke M. Zangl, Ishan Chakravarty, Zachary S. Morris, Ian Marsh, Joseph Grudzinski, KyungMann Kim, Justin C. Jagodinsky, Amber M. Bates, Jamey P. Weichert, Bryan Bednarz, Todd E. Barnhart, Eduardo Aluicio-Sarduy, Trang T. Le, Won Jong Jin, Peter M. Carlson, Sarah E. Emma, Caroline Kerr, Jonathan W. Engle, Reinier Hernandez
Publikováno v:
Cancer Research. 81:3060-3060
Background: Radiation (RT) activates a type 1 interferon (IFN1) response and this is critical to the effect of RT in priming a response to immune checkpoint blockade (ie anti-CTLA4). However, little is known about the time course of this effect. Clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba3efdd4df97c84064850ebeb05a15f2
https://doi.org/10.1158/1538-7445.am2021-3060
https://doi.org/10.1158/1538-7445.am2021-3060
Autor:
Zachary S. Morris, Ishan Chakravarty, Keng-Hsueh S. Lan, Justin C. Jagodinsky, Raghava N. Sriramaneni, Wonjong Jin, Jessica R. Miller, Paul A. Clark, Sarah E. Emma, Ian S. Arthur, Rupak K. Das
Publikováno v:
Brachytherapy. 20:S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b93c10e89de90873de36ddc18529b30
https://doi.org/10.1016/j.brachy.2021.05.029
https://doi.org/10.1016/j.brachy.2021.05.029