Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ishak D. Irwan"'
Autor:
Ishak D. Irwan, Bryan R. Cullen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/4cc0b8681141460daf51c609714b1fc6
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA i
Externí odkaz:
https://doaj.org/article/e89049ba44c846f8b00d93509c7f0941
Publikováno v:
Nature microbiology. 7(12)
After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a genome-wide CRISPR/Cas9 knockout screen, we identified the host SMC5/6 comple
Autor:
Ishak D. Irwan, Bryan R. Cullen
Publikováno v:
J Virol
We previously reported that the normally essential step of integration of the HIV-1 proviral DNA intermediate into the host cell genome becomes dispensable in T cells that express the human T cell leukemia virus 1 (HTLV-1) Tax protein, a known activa
Autor:
Ishak D. Irwan, Astrid Irwanto, Tri Hesti Wahyuni, Jianjun Liu, Hana Krismawati, Yuli Arisanti Sitanggang, Yonghu Sun, Yustinus Maladan, Furen Zhang, Ratna Tanjung, Arry Pongtiku, Antonius Oktavian, Hong Liu
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008746 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation. Multi-drug therapy which consists of dapsone, rifampicin and clofazimine has been effective to combat this disease. In Indonesia, esp
Publikováno v:
mBio
mBio, Vol 11, Iss 3, p e01038-20 (2020)
mBio, Vol 11, Iss 3 (2020)
mBio, Vol 11, Iss 3, p e01038-20 (2020)
mBio, Vol 11, Iss 3 (2020)
While retroviral DNA is synthesized normally after infection by integrase-deficient viruses, the resultant episomal DNA is then epigenetically silenced. Here, we show that expression of the Tax transcription factor encoded by a second human retroviru
Integration of the proviral DNA intermediate into the host cell genome represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is epigenetically s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b636bdf8e037d0d8713a32c5cab9b533
https://doi.org/10.1101/2020.03.18.997023
https://doi.org/10.1101/2020.03.18.997023
Publikováno v:
Virology. 520:116-126
DNA editing using CRISPR/Cas has emerged as a potential treatment for diseases caused by pathogenic human DNA viruses. One potential target is HIV-1, which replicates via a chromosomally integrated DNA provirus. While CRISPR/Cas can protect T cells f
Autor:
Ishak D. Irwan, Jianjun Liu, Kyuyoung Song, E-Shyong Tai, Ho-Sung Ryu, Myunghee Hong, Herty Liany, Jimmy Lee, Tien Yin Wong, Louis C. Tan, Tat Hung Koh, Chiea Chuen Khor, Siow Ann Chong, Sun Ju Chung, Tin Aung, Jia Nee Foo, Wing Lok Au, Kumar M. Prakash, Ching-Yu Cheng, Eranga N. Vithana, Eng-King Tan
Publikováno v:
Movement Disorders. 31:484-487
Background Genome-wide association studies have identified several loci associated with Parkinson's disease (PD). Whole-exome sequencing detects rare coding variants, but their links with PD genome-wide association study loci are unknown. Our objecti
Autor:
Anne Y.Y. Chan, Wing Lok Au, Yusun Jung, Jimmy Lee, Jianjun Liu, Kyuyoung Song, Siow Ann Chong, Shen-Yang Lim, Azlina Ahmad-Annuar, Kumar M. Prakash, Jia Nee Foo, Eng-King Tan, Juyeon Kim, Yen Yek Ng, Tin Aung, Vincent Mok, Tat Hung Koh, Herty Liany, Sun Ju Chung, Louis C.S. Tan, Eranga N. Vithana, Chiea Chuen Khor, Tien Yin Wong, Ishak D. Irwan, E. Shyong Tai
Publikováno v:
Human Molecular Genetics. 23:3891-3897
To evaluate the contribution of non-synonymous-coding variants of known familial and genome-wide association studies (GWAS)-linked genes for Parkinson's disease (PD) to PD risk in the East Asian population, we sequenced all the coding exons of 39 PD-