Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ishai Rabinovitz"'
Publikováno v:
Inhalation Toxicology. 31:203-211
Objective: Sarin is an irreversible organophosphate cholinesterase inhibitor and a highly toxic, volatile warfare agent. Rats and guinea pigs exposed to sarin display cholinergic excitotoxi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5d36a3dc26b204b6ebf4c2bc3f6e87
https://doi.org/10.1080/08958378.2019.1644402
https://doi.org/10.1080/08958378.2019.1644402
Autor:
Eugenia Bloch-Shilderman, Ishai Rabinovitz, Hila Gutman, Guy Yacov, Rellie Gez, Uri Nili, Liat Cohen, Inbal Egoz
Publikováno v:
Archives of Toxicology. 93:1365-1384
Exposure to the chemical warfare nerve agent VX is extremely toxic, causing severe cholinergic symptoms. If not appropriately treated, death ultimately ensues. Based on our previously described whole-body vapor exposure system, we characterized in de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1920fa50446640429755b048f0f8a496
https://doi.org/10.1007/s00204-019-02401-0
https://doi.org/10.1007/s00204-019-02401-0
Publikováno v:
Archives of Toxicology. 92:873-892
VX, a potent inhibitor of cholinesterase (ChE), is considered as one of the most toxic, persistent and least volatile nerve agents. VX is absorbed in various environmental surfaces and is gradually released long after its initial dispersal. Its toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1fb1d982052cc9601a0cecf7d4d61c5
https://doi.org/10.1007/s00204-017-2108-5
https://doi.org/10.1007/s00204-017-2108-5
Autor:
Eran Gilat, Ishai Rabinovitz, Guy Yaakov, Inbal Egoz, Lily Raveh, Shira Chapman, Tamar Kadar, Ettie Grauer
Publikováno v:
NeuroToxicology. 49:132-138
Sarin poisoned rats display a hyper-cholinergic activity including hypersalivation, tremors, seizures and death. Here we studied the time and dose effects of midazolam treatment following nerve agent exposure. Rats were exposed to sarin (1.2 LD50, 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a954042fde0929039656843dc9bceb25
https://doi.org/10.1016/j.neuro.2015.05.001
https://doi.org/10.1016/j.neuro.2015.05.001
Autor:
Guy Yaacov, Vered Horwitz, Maayan Cohen, Hila Gutman, Ishai Rabinovitz, Liat Cohen, Shlomit Dachir, Tamar Kadar
Publikováno v:
Drug and chemical toxicology. 42(3)
Sulfur mustard (SM) is an incapacitating chemical warfare agent used in numerous conflicts around the world and it is still a major threat for both, army troops and civilians. To evaluate its multiple targets effects in experimental setup, a model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd4411ce6f87c29b62e6dfbc6df4f69
https://pubmed.ncbi.nlm.nih.gov/29171299
https://pubmed.ncbi.nlm.nih.gov/29171299
Autor:
Ishai Rabinovitz, Inbal Egoz, Joseph Kapon, Nahum Allon, G. Yacov, Ben-Avi Weissman, Eugenia Bloch-Shilderman, Ettie Grauer, Shira Chapman
Publikováno v:
Toxicology and Applied Pharmacology. 253:31-37
The main injuries among victims of the terrorist act in the Tokyo subway resulted from sub-lethal inhalation and whole body exposure to sarin vapor. In order to study the long term effects of such exposure and to simulate these conditions, freely mov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732bafcb940e8e942034cdbfc62f9efc
https://doi.org/10.1016/j.taap.2011.03.007
https://doi.org/10.1016/j.taap.2011.03.007
Publikováno v:
Electronic Notes in Theoretical Computer Science. 144:67-77
The standard translation of a Bounded Model Checking (BMC) instance into a satisfiability problem, (a.k.a SAT), might produce misleading results in the case when the model under verification contains finite paths. Models with finite paths might be pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f54227c9e07553fa07be74e67b046b4
https://doi.org/10.1016/j.entcs.2005.07.020
https://doi.org/10.1016/j.entcs.2005.07.020
Acute and Long-Lasting Cardiac Changes Following a Single Whole-Body Exposure to Sarin Vapor in Rats
Publikováno v:
Toxicological Sciences. 87:385-390
Epinephrine-induced arrhythmias (EPIA) are known to be associated with local cardiac cholinergic activation. The present study examined the development of QT prolongation and the effect on EPIA of whole-body exposure of animals to a potent acetylchol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb6bb2c9603222fb6b970e132256468
https://doi.org/10.1093/toxsci/kfi263
https://doi.org/10.1093/toxsci/kfi263
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:1082-1089
The protein kinase C (PKC) signaling pathway has been associated with modulation of N-metyl-D-aspartate receptor activity, motor behavior, learning, and memory, all of which are severely impaired in organophosphate (OP) intoxication. Nevertheless, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a807fd93e9462cf194f3e5d445063729
https://doi.org/10.1124/jpet.105.083469
https://doi.org/10.1124/jpet.105.083469
Autor:
Eran Gilat, Ben Avi Weissman, David Alkalay, Hagar Sonego, Lily Raveh, Rachel Brandeis, Ishai Rabinovitz, Giora Cohen
Publikováno v:
Annals of the New York Academy of Sciences. 1025:584-589
Several drugs of abuse are known to produce an array of deleterious effects, including alterations in neuronal circuitry and, ultimately, neuronal degeneration. For instance, methamphetamine was shown to induce substantial nigrostriatal dopaminergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ef10aea1028ebadbb5306bc00fc68a
https://doi.org/10.1196/annals.1316.072
https://doi.org/10.1196/annals.1316.072