Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Isha M. Wilson"'
Publikováno v:
FEBS Open Bio, Vol 12, Iss 9, Pp 1567-1583 (2022)
Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response. The SARS‐CoV‐2 pande
Externí odkaz:
https://doaj.org/article/4f34b159ad4f4aff82ea99ddef73b102
Autor:
Meredith N. Frazier, Isha M. Wilson, Juno M. Krahn, Kevin John Butay, Lucas B. Dillard, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nucleic Acids Res
Coronaviruses generate double-stranded (ds) RNA intermediates during viral replication that can activate host immune sensors. To evade activation of the host pattern recognition receptor MDA5, coronaviruses employ Nsp15, which is a uridine-specific e
Global sequencing efforts from the ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, continue to provide insight into the evolution of the viral genome. Coronaviruses encode 16 nonstructural proteins, within the first two-thirds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2736d629b2bd3ff2214b0e8c7d6c160
https://doi.org/10.1101/2022.05.10.491349
https://doi.org/10.1101/2022.05.10.491349
Autor:
Mario J. Borgnia, Leesa J. Deterding, Robin E. Stanley, Lucas B. Dillard, Juno M. Krahn, Monica C. Pillon, Lalith Perera, Isha M Wilson, Jason Williams, Zachary D. Stewart, Meredith N Frazier
Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA and evade host immune defense systems. Previous structures of Nsp15 from across Coronaviridae revealed that Nsp15 assembles into a homo-hexamer and has a conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d29d1330e1e81e5cf908f6dcc3034c3
https://doi.org/10.1101/2021.06.01.446181
https://doi.org/10.1101/2021.06.01.446181