Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ish K. Khanna"'
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f9513e934e8bf576a289475c31d0e
https://doi.org/10.1016/j.bmcl.2005.11.008
https://doi.org/10.1016/j.bmcl.2005.11.008
Autor:
Yu Yi, Jacquelen J. Casler, Peter C. Isakson, Jaime L. Masferrer, Ish K. Khanna, Francis J. Koszyk, Paul W. Collins, Karen Seibert, Richard M. Weier, Yan Zhang, A. W. Veenhuizen, Carol M. Koboldt, Xiangdong Xu, William E. Perkins, S. A. Gregory
Publikováno v:
Journal of Medicinal Chemistry. 40:1634-1647
Series of 1,2-diarylimidazoles has been synthesized and found to contain highly potent and selective inhibitors of the human COX-2 enzyme. The paper describes a short synthesis of the target 1,2-diarylimidazoles starting with aryl nitriles. Different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93724e239a9064506c442ec529d65fd
https://doi.org/10.1021/jm9700225
https://doi.org/10.1021/jm9700225
Autor:
Richard M. Weier, Julie M. Miyashiro, Karen Seibert, Jerry L. Currie, Paul W. Collins, Ish K. Khanna, A. W. Veenhuizen, Carol M. Koboldt, Peter C. Isakson, Yu Yi
Publikováno v:
Journal of Medicinal Chemistry. 40:1619-1633
Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent and selective inhibitors of the human cyclooxygenase-2 (COX-2) enzyme. The paper describes short and practical syntheses of the target molecules utilizing the Paal-Kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae2f38b3e790d46f5eb64f1d1bd7a11
https://doi.org/10.1021/jm970036a
https://doi.org/10.1021/jm970036a
Publikováno v:
Tetrahedron Letters. 37:1355-1358
The regio- and stereoselective synthesis of the title compounds 3 and 4 has been accomplished starting with deoxynojirimycin. The factors affecting the stereochemical outcome of Grignard addition to the key carbonyl intermediate are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9a07e65dedba45900ae4950f6fdbd51
https://doi.org/10.1016/0040-4039(96)00021-4
https://doi.org/10.1016/0040-4039(96)00021-4
Autor:
Shashidhar N. Rao, Francis J. Koszyk, Ish K. Khanna, Decrescenzo Gary A, Getman Daniel P, Janet Anne Julien, Richard M. Weier, Stealey Michael A, Heintz Robert M, Richard A. Mueller, Lydia Swenton
Publikováno v:
Journal of Carbohydrate Chemistry. 14:843-878
A useful methodology for the synthesis of a number of 2-, 3- and 2,3-disubstituted deoxynojirimycin analogs is reported. It has been found that the epoxides in stereoselectively synthesized N-carboalkoxy-2,3-anhydro-1-deoxymannojirimycins (4 and 5) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97befdaa53d580da61e6afa663f24b01
https://doi.org/10.1080/07328309508005380
https://doi.org/10.1080/07328309508005380
Publikováno v:
The Journal of Organic Chemistry. 60:960-965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e080dd174b2e41307eba698baf16ca3
https://doi.org/10.1021/jo00109a029
https://doi.org/10.1021/jo00109a029
Autor:
Richard M. Weier, Ish K. Khanna
Publikováno v:
Tetrahedron Letters. 34:1885-1888
The addition of Grignard reagents to 5-acylimidazopyridinium salts gives 4-substituted 5-acyl-4,5-dihydroimidazopyridines. This reaction was utilized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac323b06c2037c78373729014f2fed0b
https://doi.org/10.1016/s0040-4039(00)91954-3
https://doi.org/10.1016/s0040-4039(00)91954-3
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5d907f44a10f05b5f6a45a19ca1696
https://doi.org/10.1002/chin.199533160
https://doi.org/10.1002/chin.199533160
Publikováno v:
ChemInform. 27
The regio- and stereoselective synthesis of the title compounds 3 and 4 has been accomplished starting with deoxynojirimycin. The factors affecting the stereochemical outcome of Grignard addition to the key carbonyl intermediate are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44b7f15879e018e35ffaad8a8bfabe09
https://doi.org/10.1002/chin.199624209
https://doi.org/10.1002/chin.199624209
Autor:
Peter C. Isakson, Jerry L. Currie, Ish K. Khanna, A. W. Veenhuizen, Carol M. Koboldt, Yu Yi, Richard M. Weier, Karen Seibert, Paul W. Collins, Julie M. Miyashiro
Publikováno v:
ChemInform. 28
Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent and selective inhibitors of the human cyclooxygenase-2 (COX-2) enzyme. The paper describes short and practical syntheses of the target molecules utilizing the Paal−K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4baa3af8f4d1cea2c23a7407e3e82c
https://doi.org/10.1002/chin.199739134
https://doi.org/10.1002/chin.199739134