Zobrazeno 1 - 10
of 5 782
pro vyhledávání: '"Ischaemia-reperfusion"'
Autor:
Erman Caner Bulut, Deniz Erol Kutucu, Savaş Üstünova, Mehmet Ağırbaşlı, Huri Dedeakayoğulları, Çağatay Tarhan, Ayşegül Kapucu, Berrak Ç. Yeğen, Cihan Demirci Tansel, Ebru Gürel Gürevin
Publikováno v:
Experimental Physiology, Vol 109, Iss 11, Pp 1882-1895 (2024)
Abstract Hyperglycaemia, hyperlipidaemia, hypertension and obesity are the main risk factors affecting the development and prognosis of ischaemic heart disease, which is still an important cause of death today. In our study, male Sprague–Dawley rat
Externí odkaz:
https://doaj.org/article/a40ae1cf10994dc8bb1bd4a36078b1dc
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Acute myocardial infarction (AMI) and related cardiovascular disease complications are the leading causes of mortality worldwide. Brown adipose tissue (BAT) is thermogenic and characterized by the uncoupling protein expression. Recent studie
Externí odkaz:
https://doaj.org/article/06d55d51bd604c60848092617d70323b
Autor:
Jarmon G. Lees, David W. Greening, David A. Rudd, Jonathon Cross, Ayeshah A. Rosdah, Xiangfeng Lai, Tsung Wu Lin, Ren Jie Phang, Anne M. Kong, Yali Deng, Simon Crawford, Jessica K. Holien, Derek J. Hausenloy, Hsin-Hui Shen, Shiang Y. Lim
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100085- (2024)
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a cardiac-targeted nanopa
Externí odkaz:
https://doaj.org/article/c5ae7e34af804835a24c75f371f23c34
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundSalvianolic acid B is the most abundant water-soluble component in the traditional Chinese medicine Danshen and can reduce myocardial ischemia-reperfusion (MI/R) injury through multiple targets and pathways. However, the role of SalB in pro
Externí odkaz:
https://doaj.org/article/dadefc049d41416bb02eb4ff557db552
Autor:
zi-hao Jiang, jun-sheng Wang, jin-ling Wang, jiang-fan Zheng, xiao-ling Li, zhi-cheng Yang, meng-qiu Xu, yong-li Zhang, yu Wang
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37018- (2024)
Background: Ischaemia–reperfusion injury (IRI) is a critical complication post-limb replantation. The oxidative stress and cellular apoptosis due to IRI considerably hinder the healing process. This study aimed to investigate the modulatory effects
Externí odkaz:
https://doaj.org/article/531b39fbbcda48c0b35f44376d8c9f60
Publikováno v:
Experimental Physiology, Vol 109, Iss 4, Pp 524-534 (2024)
Abstract Hindlimb ischaemia–reperfusion (IR) is among the most prominent pathophysiological conditions observed in peripheral artery disease (PAD). An exaggerated arterial blood pressure (BP) response during exercise is associated with an elevated
Externí odkaz:
https://doaj.org/article/66d3fb708c73454db2a3913f2c01bcb6
Publikováno v:
ESC Heart Failure, Vol 11, Iss 2, Pp 1009-1021 (2024)
Abstract Aims Myocardial ischaemia–reperfusion injury (MIRI) contributes to serious myocardial injury and even death. Long non‐coding RNAs (lncRNAs) have been reported to play pivotal roles in the occurrence and development of MIRI. Here, the det
Externí odkaz:
https://doaj.org/article/6150af52c44249bf9b2dac175d98b83d
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTHeart failure, a leading driver of global mortality, remains a topic of intense contemporary research interest due to the prevailing unmet need in cardiometabolic therapeutics. Numerous mechanisms with the potential to influence the onset and
Externí odkaz:
https://doaj.org/article/7924a5ec7a0b46bf9182d15a49b41aa3
Autor:
Ping Sun, Yifei Li, Weidong Yu, Jianfeng Chen, Pingping Wan, Zhuo Wang, Maomao Zhang, Chao Wang, Shuai Fu, Ge Mang, Stephen Choi, Zhuo Du, Caiying Tang, Song Li, Guoxia Shi, Jiawei Tian, Jiannan Dai, Xiaoping Leng
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Abstract During myocardial ischaemia‒reperfusion injury (MIRI), the accumulation of damaged mitochondria could pose serious threats to the heart. The migrasomes, newly discovered mitocytosis‐mediating organelles, selectively remove damaged mitoch
Externí odkaz:
https://doaj.org/article/43fa46a3c0ce4648b3ec99def8dc556c
Autor:
Annabel Sorby-Adams, Tracy A. Prime, Jan Lj Miljkovic, Hiran A. Prag, Thomas Krieg, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103161- (2024)
Ischaemia-reperfusion (IR) injury is the paradoxical consequence of the rapid restoration of blood flow to an ischaemic organ. Although reperfusion is essential for tissue survival in conditions such as myocardial infarction and stroke, the excessive
Externí odkaz:
https://doaj.org/article/8882b64fa8b24025a82708cfa672f55d