Zobrazeno 1 - 10
of 5 786
pro vyhledávání: '"Ischaemia reperfusion"'
Publikováno v:
Experimental Physiology, Vol 109, Iss 12, Pp 2073-2087 (2024)
Abstract Intestinal ischaemia–reperfusion (I/R) is a common clinical pathology with high incidence and mortality rates. However, the mechanisms underlying intestinal I/R injury remain unclear. In this study, we investigated the role and mechanism o
Externí odkaz:
https://doaj.org/article/a67fd2466fe74b259c3c951f3d394618
Autor:
Erman Caner Bulut, Deniz Erol Kutucu, Savaş Üstünova, Mehmet Ağırbaşlı, Huri Dedeakayoğulları, Çağatay Tarhan, Ayşegül Kapucu, Berrak Ç. Yeğen, Cihan Demirci Tansel, Ebru Gürel Gürevin
Publikováno v:
Experimental Physiology, Vol 109, Iss 11, Pp 1882-1895 (2024)
Abstract Hyperglycaemia, hyperlipidaemia, hypertension and obesity are the main risk factors affecting the development and prognosis of ischaemic heart disease, which is still an important cause of death today. In our study, male Sprague–Dawley rat
Externí odkaz:
https://doaj.org/article/a40ae1cf10994dc8bb1bd4a36078b1dc
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Acute myocardial infarction (AMI) and related cardiovascular disease complications are the leading causes of mortality worldwide. Brown adipose tissue (BAT) is thermogenic and characterized by the uncoupling protein expression. Recent studie
Externí odkaz:
https://doaj.org/article/06d55d51bd604c60848092617d70323b
Autor:
Jiaxuan He, Siyuan Li, Yunpeng Teng, Hongfei Xiong, Zhuang Wang, Xiaoyao Han, Wei Gong, Ya Gao
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Dual-specificity phosphatase 12 (DUSP12) is abnormally expressed under various pathological conditions and plays a crucial role in the pathological progression of disorders. However, the role of DUSP12 in cerebral ischaemia/reperfusion injury has not
Externí odkaz:
https://doaj.org/article/296751f4cf244c938fe9fae03bf73efe
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTHeart failure, a leading driver of global mortality, remains a topic of intense contemporary research interest due to the prevailing unmet need in cardiometabolic therapeutics. Numerous mechanisms with the potential to influence the onset and
Externí odkaz:
https://doaj.org/article/7924a5ec7a0b46bf9182d15a49b41aa3
Autor:
Rui Li, Jiechun Zhang, Shuliang Ji, Junfeng Fang, Xiaodong Ji, Yanping Zeng, Nan Liu, Wei Wu, Shiyi Liu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundAutophagy‒endoplasmic reticulum (ER) stress axis dysregulation is linked to myocardial ischemia‒reperfusion injury (MIRI), which counteracts the benefits of acute myocardial infarction (AMI) reperfusion therapy. Qingre Huoxue decoction
Externí odkaz:
https://doaj.org/article/60d4b3ebc1b6401bb9ca8cebcf5c5d45
Publikováno v:
Experimental Physiology, Vol 109, Iss 4, Pp 524-534 (2024)
Abstract Hindlimb ischaemia–reperfusion (IR) is among the most prominent pathophysiological conditions observed in peripheral artery disease (PAD). An exaggerated arterial blood pressure (BP) response during exercise is associated with an elevated
Externí odkaz:
https://doaj.org/article/66d3fb708c73454db2a3913f2c01bcb6
Publikováno v:
ESC Heart Failure, Vol 11, Iss 2, Pp 1009-1021 (2024)
Abstract Aims Myocardial ischaemia–reperfusion injury (MIRI) contributes to serious myocardial injury and even death. Long non‐coding RNAs (lncRNAs) have been reported to play pivotal roles in the occurrence and development of MIRI. Here, the det
Externí odkaz:
https://doaj.org/article/6150af52c44249bf9b2dac175d98b83d
Autor:
Jarmon G. Lees, David W. Greening, David A. Rudd, Jonathon Cross, Ayeshah A. Rosdah, Xiangfeng Lai, Tsung Wu Lin, Ren Jie Phang, Anne M. Kong, Yali Deng, Simon Crawford, Jessica K. Holien, Derek J. Hausenloy, Hsin-Hui Shen, Shiang Y. Lim
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100085- (2024)
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a cardiac-targeted nanopa
Externí odkaz:
https://doaj.org/article/c5ae7e34af804835a24c75f371f23c34
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundSalvianolic acid B is the most abundant water-soluble component in the traditional Chinese medicine Danshen and can reduce myocardial ischemia-reperfusion (MI/R) injury through multiple targets and pathways. However, the role of SalB in pro
Externí odkaz:
https://doaj.org/article/dadefc049d41416bb02eb4ff557db552