Zobrazeno 1 - 10
of 2 958
pro vyhledávání: '"Ischaemia/reperfusion injury"'
Autor:
Jarmon G. Lees, David W. Greening, David A. Rudd, Jonathon Cross, Ayeshah A. Rosdah, Xiangfeng Lai, Tsung Wu Lin, Ren Jie Phang, Anne M. Kong, Yali Deng, Simon Crawford, Jessica K. Holien, Derek J. Hausenloy, Hsin-Hui Shen, Shiang Y. Lim
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100085- (2024)
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a cardiac-targeted nanopa
Externí odkaz:
https://doaj.org/article/c5ae7e34af804835a24c75f371f23c34
Autor:
zi-hao Jiang, jun-sheng Wang, jin-ling Wang, jiang-fan Zheng, xiao-ling Li, zhi-cheng Yang, meng-qiu Xu, yong-li Zhang, yu Wang
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37018- (2024)
Background: Ischaemia–reperfusion injury (IRI) is a critical complication post-limb replantation. The oxidative stress and cellular apoptosis due to IRI considerably hinder the healing process. This study aimed to investigate the modulatory effects
Externí odkaz:
https://doaj.org/article/531b39fbbcda48c0b35f44376d8c9f60
Publikováno v:
ESC Heart Failure, Vol 11, Iss 2, Pp 1009-1021 (2024)
Abstract Aims Myocardial ischaemia–reperfusion injury (MIRI) contributes to serious myocardial injury and even death. Long non‐coding RNAs (lncRNAs) have been reported to play pivotal roles in the occurrence and development of MIRI. Here, the det
Externí odkaz:
https://doaj.org/article/6150af52c44249bf9b2dac175d98b83d
Autor:
Ping Sun, Yifei Li, Weidong Yu, Jianfeng Chen, Pingping Wan, Zhuo Wang, Maomao Zhang, Chao Wang, Shuai Fu, Ge Mang, Stephen Choi, Zhuo Du, Caiying Tang, Song Li, Guoxia Shi, Jiawei Tian, Jiannan Dai, Xiaoping Leng
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Abstract During myocardial ischaemia‒reperfusion injury (MIRI), the accumulation of damaged mitochondria could pose serious threats to the heart. The migrasomes, newly discovered mitocytosis‐mediating organelles, selectively remove damaged mitoch
Externí odkaz:
https://doaj.org/article/43fa46a3c0ce4648b3ec99def8dc556c
Autor:
Annabel Sorby-Adams, Tracy A. Prime, Jan Lj Miljkovic, Hiran A. Prag, Thomas Krieg, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103161- (2024)
Ischaemia-reperfusion (IR) injury is the paradoxical consequence of the rapid restoration of blood flow to an ischaemic organ. Although reperfusion is essential for tissue survival in conditions such as myocardial infarction and stroke, the excessive
Externí odkaz:
https://doaj.org/article/8882b64fa8b24025a82708cfa672f55d
Autor:
Hernán González‐King, Patricia G. Rodrigues, Tamsin Albery, Benyapa Tangruksa, Ramya Gurrapu, Andreia M. Silva, Gentian Musa, Dominika Kardasz, Kai Liu, Bengt Kull, Karin Åvall, Katarina Rydén‐Markinhuhta, Tania Incitti, Nitin Sharma, Cecilia Graneli, Hadi Valadi, Kasparas Petkevicius, Miguel Carracedo, Sandra Tejedor, Alena Ivanova, Sepideh Heydarkhan‐Hagvall, Phillipe Menasché, Jane Synnergren, Niek Dekker, Qing‐Dong Wang, Karin Jennbacken
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Small extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial infarction (MI). The aim of this study was to compare different sources of sEV for ca
Externí odkaz:
https://doaj.org/article/c768354e5bb04d27b8a38ee892355c5b
Autor:
Jiaxuan He, Siyuan Li, Yunpeng Teng, Hongfei Xiong, Zhuang Wang, Xiaoyao Han, Wei Gong, Ya Gao
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
AbstractDual-specificity phosphatase 12 (DUSP12) is abnormally expressed under various pathological conditions and plays a crucial role in the pathological progression of disorders. However, the role of DUSP12 in cerebral ischaemia/reperfusion injury
Externí odkaz:
https://doaj.org/article/296751f4cf244c938fe9fae03bf73efe
Autor:
Tianfeng Hua, Yuqian Chu, Minjie Wang, Yijun Zhang, Wei Shi, Qihui Huang, Liangliang Zhang, Min Yang
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some patients may eventua
Externí odkaz:
https://doaj.org/article/55a82a3e8e8640d79045fd1fe6cccd81
Publikováno v:
ESC Heart Failure, Vol 10, Iss 5, Pp 3077-3090 (2023)
Abstract Aims Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen‐rich saline (HRS) could scavenge free radicals selectively and alleviate the inflammatory response in the myo
Externí odkaz:
https://doaj.org/article/88120eb314d04ebcb4659d232663f4b7
Autor:
Sandy M. Chu, Lisa C. Heather, Surawee Chuaiphichai, Thomas Nicol, Benjamin Wright, Matthieu Miossec, Jennifer K. Bendall, Gillian Douglas, Mark J. Crabtree, Keith M. Channon
Publikováno v:
Experimental Physiology, Vol 108, Iss 6, Pp 874-890 (2023)
Abstract Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthases in which its production of NO is crucial for cardiac function. However, non‐canonical roles of BH4 have been discovered recently and the cell‐specific rol
Externí odkaz:
https://doaj.org/article/61590d2d50ea48dca07378de1d92d796