Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis.

Autor: Isaque Medeiros Siqueira, Marcel Wüthrich, Mengyi Li, Huafeng Wang, Lucas de Oliveira Las-Casas, Raffael Júnio Araújo de Castro, Bruce Klein, Anamelia Lorenzetti Bocca

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008386 (2020)

Chromoblastomycosis (CBM) is a chronic worldwide subcutaneous mycosis, caused by several dimorphic, pigmented dematiaceous fungi. It is difficult to treat patients with the disease, mainly because of its recalcitrant nature. The correct activation of

Externí odkaz: https://doaj.org/article/8f16882f50844610b56bd1b0b734593c

Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity.

Autor: Isaque Medeiros Siqueira, Raffael Júnio Araújo de Castro, Luiza Chaves de Miranda Leonhardt, Márcio Sousa Jerônimo, Aluízio Carlos Soares, Tainá Raiol, Christiane Nishibe, Nalvo Almeida, Aldo Henrique Tavares, Christian Hoffmann, Anamelia Lorenzetti Bocca

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005461 (2017)

A common theme across multiple fungal pathogens is their ability to impair the establishment of a protective immune response. Although early inflammation is beneficial in containing the infection, an uncontrolled inflammatory response is detrimental

Externí odkaz: https://doaj.org/article/a0c719b8bdaf4932a5f0f69279af272d

Imunopatologia da cromoblastomicose: modulação da resposta inflamatória por formas do fungo fonsecaea pedrosoi e seu impacto na cromoblastomicose murina

Autor: Isaque Medeiros Siqueira

Publikováno v: Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB

Tese (doutorado)—Universidade de Brasília, Faculdade de Medicina, Pós-Graduação em Patologia Molecular, 2016. A cromoblastomicose (CBM) é uma micose subcutânea, crônica, de distribuição cosmopolita, causada por vários fungos demáceos, pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899ae3014b95db76a5ab75d6519a2909
https://doi.org/10.26512/2016.02.t.21140

Distinct patterns of yeast cell morphology and host responses induced by representative strains ofParacoccidioides brasiliensis(Pb18) andParacoccidioides lutzii(Pb01)

Autor: Márcio Souza Jerônimo, Aldo Henrique Tavares, Kelly Grace Magalhães, Isaque Medeiros Siqueira, Andre Correa Amaral, Carlos Antonio Inácio, Pedro Henrique Burguel, Ana Camila Oliveira Souza, Maria Sueli Soares Felipe, Cecília Lívia Falcomer Fraga, Anamélia Lorenzetti Bocca, Alice Melo Ribeiro, José R. Corrêa

Publikováno v: Medical Mycology. 54:177-188

Paracoccidioidomycosis (PCM) is a systemic mycosis, widespread in Latin America. PCM is a granulomatous disease characterized by a polymorphism of lesions depending on the pathogen's virulence, the immune status of the host and its genetic susceptibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df91f35af547332df50f619f7e5bad8d
https://doi.org/10.1093/mmy/myv072

Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity

Autor: Márcio Sousa Jerônimo, Anamélia Lorenzetti Bocca, Aluízio Carlos Soares, Christiane Nishibe, Tainá Raiol, Christian Hoffmann, Luiza Chaves de Miranda Leonhardt, Aldo Henrique Tavares, Isaque Medeiros Siqueira, Raffael Júnio Araújo de Castro, Nalvo F. Almeida

Publikováno v: Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005461 (2017)
PLoS Neglected Tropical Diseases
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

A common theme across multiple fungal pathogens is their ability to impair the establishment of a protective immune response. Although early inflammation is beneficial in containing the infection, an uncontrolled inflammatory response is detrimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3dc7569714326e4060ba1878e78fa5
http://repositorio.unb.br/handle/10482/23688