Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Isao Yasumatsu"'
Autor:
Isao Yasumatsu, Kei Moritsugu, Narutoshi Kamiya, Yoshifumi Fukunishi, Ikuo Fukuda, Koh Takeuchi, Junichi Higo
Publikováno v:
Journal of Chemical Information and Modeling. 61:1921-1930
Quantifying the cell permeability of cyclic peptides is crucial for their rational drug design. However, the reasons remain unclear why a minor chemical modification, such as the difference between Ras inhibitors cyclorasin 9A5 and 9A54, can substant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5264539c0403704cdd5161e01ebdeca4
https://doi.org/10.1021/acs.jcim.0c01427
https://doi.org/10.1021/acs.jcim.0c01427
Autor:
Ken Ishii, Munefumi Torihata, Eisuke Tsuda, Keiichi Yotsumoto, Hideki Terashima, Isao Yasumatsu, Takashi Ishiyama, Katagiri Takahiro, Katsushi Katayama, Makoto Suzuki, Kumiko Hiramoto, Tsuyoshi Muto
Publikováno v:
ACS Med Chem Lett
[Image: see text] Therapeutic reactivation of the γ-globin genes for fetal hemoglobin (HbF) production is an attractive strategy for treating β-thalassemia and sickle cell disease. It was reported that genetic knockdown of the histone lysine methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac9b7958989207e99cc953ca19a627c
https://doi.org/10.1021/acsmedchemlett.0c00572
https://doi.org/10.1021/acsmedchemlett.0c00572
Autor:
Makoto Yamagishi, Yuta Kuze, Makoto Nakashima, Seiichiro Kobayashi, Satoko Morishima, Toyotaka Kawamata, Junya Makiyama, Kazumi Abe, Kiyomi Imamura, Eri Watanabe, Kazumi Tsuchiya, Isao Yasumatsu, Gensuke Takayama, Kazumi Ito, Yasuhito Nannya, Arinobu Tojo, Toshiki Watanabe, Shinji Tsutsumi, Yutaka Suzuki, Kaoru Uchimaru
Publikováno v:
Blood. 140:756-757
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7790e8d232f3d6a0302478086593da0
https://doi.org/10.1182/blood-2022-159275
https://doi.org/10.1182/blood-2022-159275
Autor:
Hiroaki Inagaki, Toru Taniguchi, Isao Yasumatsu, Masaki Kiga, Yoshihiro Shibata, Akiko Toyota, Hiroki Shimizu, Takashi Odagiri, Yasuyuki Kaneta, Daichi Baba, Shin Iimura, Kiyono Ueda, Tomoki Imaoka, Maki Seo, Kiyoshi Nakayama
Publikováno v:
ACS Med Chem Lett
[Image: see text] To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1, which has a pyridine moiety, was found. Referring to their X-ray crystal str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6637d4137b06bff9a1479950c96a6145
https://doi.org/10.1021/acsmedchemlett.8b00631
https://doi.org/10.1021/acsmedchemlett.8b00631
Autor:
Eisuke Tsuda, Kumiko Hiramoto, Isao Yasumatsu, Ken Ishii, Wataru Igarashi, Makoto Suzuki, Munefumi Torihata, Katsushi Katayama, Takashi Ishiyama, Keiichi Yotsumoto, Katagiri Takahiro
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(20)
The discovery and optimization of a novel series of G9a/GLP (EHMT2/1) inhibitors are described. Starting from known G9a/GLP inhibitor 5, efforts to explore the structure-activity relationship and optimize drug properties led to a novel compound 13, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c254bc90a873849384451e47d3e569e9
https://pubmed.ncbi.nlm.nih.gov/32781218
https://pubmed.ncbi.nlm.nih.gov/32781218
Autor:
Ken Ichi Yoshida, Isao Yasumatsu, Takeshi Isoyama, Yumi Matsui, Fumie Tanzawa, Yutaka Ikeno, Shin Iimura, Hiroyuki Hanzawa, Takako Nawano, Osamu Ubukata, Hajime Fukano
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 74:156-160
Mitogen-activated protein kinase (MAPK)-interacting kinases 1 (Mnk1) and 2 (Mnk2) modulate translation initiation through the phosphorylation of eukaryotic translation initiation factor 4E, which promotes tumorigenesis. However, Mnk1 and Mnk2 are dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d1ccd2351348da24a25e43fba98d27
https://doi.org/10.1107/s2053230x18002108
https://doi.org/10.1107/s2053230x18002108
Autor:
Takeshi Takizawa, Ajay Singh Yadav, Keisuke Suzuki, Osamu Kanno, Isao Yasumatsu, Makoto Hirasawa, Akira Nakao, Daisuke Honma, Tomonori Yamasaki, Emi Nosaka, Katsuyoshi Nakajima, Machiko Shiroishi, Junzo Kinoshita, Miho Hayakawa, Watanabe Jun, Takanori Yamazaki, Nobuaki Adachi, Takao Horiuchi
Publikováno v:
Cancer Science
Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation and differentiation. Enhancer of zeste homolog 2 (EZH2) or its close homolog EZH1 functions as a catalytic subunit of PR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab3a391cc46ffb12665303c61144aad
https://doi.org/10.1111/cas.13326
https://doi.org/10.1111/cas.13326
Autor:
Hitoshi Hayasaka, Hiroyuki Hanzawa, Takashi Asahi, Shin-ichi Katakura, Isao Yasumatsu, Kazuo Kanai, Osamu Ubukata, Sachiko Takaishi, Takahiro Kitamura, Yumi Matsui
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
Tumor cells switch glucose metabolism to aerobic glycolysis by expressing the pyruvate kinase M2 isoform (PKM2) in a low active form, providing glycolytic intermediates as building blocks for biosynthetic processes, and thereby supporting cell prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9088a3f539776893db03be83553eff0
https://pubmed.ncbi.nlm.nih.gov/28511909
https://pubmed.ncbi.nlm.nih.gov/28511909
Autor:
Yoshifumi Fukunishi, Koh Takeuchi, Haruki Nakamura, Isao Yasumatsu, Takashi Kurosawa, Satoshi Yamasaki
Publikováno v:
Molecular Informatics
In order to improve docking score correction, we developed several structure‐based quantitative structure activity relationship (QSAR) models by protein‐drug docking simulations and applied these models to public affinity data. The prediction mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a7f59ca85fe7a2d40044b8ba1742ac
http://europepmc.org/articles/PMC5297997
http://europepmc.org/articles/PMC5297997
Autor:
Masaki Kiga, Kanae Suzuki, Isao Yasumatsu, Shinichi Kurakata, Etsu Tashiro, Yuji Nakamura, Tomoyuki Shibata, Tomoki Echigo, Fumie Tanzawa, Hayato Iwadare, Shiho Iwasaki, Ayako Nakayama, Fumi Inaba, Masaya Imoto, Kosaku Fujiwara, Yukiko Sasazawa
Publikováno v:
Anti-Cancer Drugs. 23:119-130
The mitogen-activated protein kinase (MAPK) signal pathway plays a central role in regulating tumor cell proliferation, survival, and differentiation. The components of this pathway, Ras/Raf/MEK/ERK, are frequently activated in human cancers. Targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd33c0d79c55a698658ad28824012b2
https://doi.org/10.1097/cad.0b013e32834c6a33
https://doi.org/10.1097/cad.0b013e32834c6a33