Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Isao Uno"'
Autor:
Isao Uno, Takaaki Kubo
Publikováno v:
Geriatrics, Vol 6, Iss 4, p 113 (2021)
We aimed to clarify the physical factors associated with the incidence of aspiration pneumonia in a community-based integrated care unit. This retrospective cohort study included 412 patients aged 65 years or older admitted to a community-based integ
Externí odkaz:
https://doaj.org/article/5b5a35d5f30b41e3864bb1f3ae2b031e
Autor:
Takaaki Kubo, Isao Uno
Publikováno v:
Geriatrics, Vol 6, Iss 113, p 113 (2021)
Geriatrics; Volume 6; Issue 4; Pages: 113
Geriatrics
Geriatrics; Volume 6; Issue 4; Pages: 113
Geriatrics
We aimed to clarify the physical factors associated with the incidence of aspiration pneumonia in a community-based integrated care unit. This retrospective cohort study included 412 patients aged 65 years or older admitted to a community-based integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501c2d6f8fe8aefb83b2f099cc62fbb8
https://www.mdpi.com/2308-3417/6/4/113
https://www.mdpi.com/2308-3417/6/4/113
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:1451-1457
X-ray crystallographic analysis was performed and several phenylahistin derivatives were synthesized to elucidate the structural components necessary for the anti-microtubule activity of phenylahistin. We primarily focused on the unique isoprenylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b16dc5cd2f71a0ad86bb887ca823e75
https://doi.org/10.1016/s0968-0896(99)00059-0
https://doi.org/10.1016/s0968-0896(99)00059-0
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 63:1130-1133
Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70670f16ce3acdedc2d1166b6abd4ace
https://doi.org/10.1271/bbb.63.1130
https://doi.org/10.1271/bbb.63.1130
Publikováno v:
The Journal of Antibiotics. 52:134-141
(-)-Phenylahistin, a fungal diketopiperazine metabolite composed of phenylalanine and isoprenylated dehydrohistidine, arrested cells in mitosis and inhibited the proliferation of A549 cells. The microtubule network in A549 cells was disrupted by (-)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7e70c79504f6d5ef136a31aeb0e88c
https://doi.org/10.7164/antibiotics.52.134
https://doi.org/10.7164/antibiotics.52.134
Publikováno v:
Biochemical and Biophysical Research Communications. 251:77-82
Vascular endothelial growth factor (VEGF) is one of the major angiogenesis regulators. It binds to its tyrosine kinase receptors, KDR and Flt-1. However, little is known about their downstream signal transduction properties. We screened human brain c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b66e3acb878d5bfe62984600e337eb
https://doi.org/10.1006/bbrc.1998.9442
https://doi.org/10.1006/bbrc.1998.9442
Autor:
Jun Katada, Michiko Muramatsu, Yoshimi Takiguchi, Yoshio Hayashi, Katsuhide Igarashi, Isao Uno, Emiko Yasuda, Yoshimi Sato, Takeo Harada
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:355-364
A novel hexapeptide, H-Pro-Ser-Nva-Gly-Asp-Trp-OH 6, a specific antagonist of platelet fibrinogen receptor (GpIIb/IIIa), was discovered in a structure-activity relationship (SAR) study where the role of the N-terminal Pro moiety of an RGD-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f805cc8bddc7cd1fddc343eb326fb5
https://doi.org/10.1016/s0968-0896(97)10050-5
https://doi.org/10.1016/s0968-0896(97)10050-5
Autor:
Hirokatsu Sekiya, Shinkichi Kohno, Isao Uno, Tohru Asari, Jun Katada, Michiko Muramatsu, Kaneo Kanoh, Takeo Harada, Hiroshi Kawashima
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2847-2852
(−)-Phenylahistin is a fungal diketopiperazine metabolite consisting of L -phenylalanine and isoprenylated dehydrohistidine, and it showed an inhibitory activity on the cell cycle progression of P388 cells in the G2/M phase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c746658094df30a678412cb731f0d63d
https://doi.org/10.1016/s0960-894x(97)10104-4
https://doi.org/10.1016/s0960-894x(97)10104-4
Autor:
Katsuhide Igarashi, Kimio Ito, Yoshio Hayashi, Jun Katada, Michiko Muramatsu, Isao Uno, Takeo Harada
Publikováno v:
Biochemical and Biophysical Research Communications. 240:850-855
We synthesized a novel potent alpha-chymotrypsin inactivator, 2,2-dimethyl-3-(N-4-cyanobenzoyl) amino-5-phenyl pentanoic anhydride, which fulfilled the criteria of a mechanism-based inactivator: first-order kinetics, irreversibility, saturation kinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9773b48bd050ce358c1e8b1cfcbf9a63
https://doi.org/10.1006/bbrc.1997.7757
https://doi.org/10.1006/bbrc.1997.7757
Autor:
Toshiki Sasaki, Iwao Ojima, Jun Katada, Isao Uno, Yoshio Hayashi, Takeo Harada, Mako Yano, Shigetaka Ishikawa, Tohru Asari, Emiko Yasuda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2099-2104
The synthetic and structure-activity relationship (SAR) studies of new non-peptide GPIIb/IIIa antagonists ( 1a-f and 3 ) were conducted by replacing one amide bond of NSL-95300 ( 2 ) with an ( E )-double bond or an enone group. NSL-95315 ( 1a ) and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f201e6c151599d194a2e8a6df443c071
https://doi.org/10.1016/s0960-894x(97)00366-1
https://doi.org/10.1016/s0960-894x(97)00366-1