Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Isao Shimokawa"'
Autor:
Seongjoon Park, Isao Shimokawa
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 873 (2024)
Currently, 30% of the global population is overweight or obese, with projections from the World Obesity Federation suggesting that this figure will surpass 50% by 2035. Adipose tissue dysfunction, a primary characteristic of obesity, is closely assoc
Externí odkaz:
https://doaj.org/article/9f292230287f4caba036e8f9c8671864
Autor:
Maiko de Kerckhove, Katsuya Tanaka, Takahiro Umehara, Momoko Okamoto, Sotaro Kanematsu, Hiroko Hayashi, Hiroki Yano, Soushi Nishiura, Shiho Tooyama, Yutaka Matsubayashi, Toshimitsu Komatsu, Seongjoon Park, Yuka Okada, Rina Takahashi, Yayoi Kawano, Takehisa Hanawa, Keisuke Iwasaki, Tadashige Nozaki, Hidetaka Torigoe, Kazuya Ikematsu, Yutaka Suzuki, Katsumi Tanaka, Paul Martin, Isao Shimokawa, Ryoichi Mori
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 10, Pp 1-21 (2018)
Abstract Argonaute 2 bound mature microRNA (Ago2‐miRNA) complexes are key regulators of the wound inflammatory response and function in the translational processing of target mRNAs. In this study, we identified four wound inflammation‐related Ago
Externí odkaz:
https://doaj.org/article/5d5fcb93f7564cd5a95e07278a823ab0
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1739 (2021)
Obesity is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), which is initiated by adipocyte-macrophage crosstalk. Among the possible molecules regulating this crosstalk, we focused on neuropeptide Y (NPY), which is know
Externí odkaz:
https://doaj.org/article/353898b62f5a4fc3903692e1da97eab7
Publikováno v:
Journal of Physical Fitness and Sports Medicine, Vol 2, Iss 3, Pp 259-266 (2013)
Restriction of food intake (calorie restriction [CR]) in laboratory animals extends their lifespan and delays the onset of various age-associated diseases, including cancer development. Recent studies revealed that the molecular mechanisms underlying
Externí odkaz:
https://doaj.org/article/a010f9e5682a47b4b2a02bec75c78bcb
Publikováno v:
Sensors, Vol 12, Iss 2, Pp 1648-1656 (2012)
Recent drug discovery efforts have utilized high throughput screening (HTS) of large chemical libraries to identify compounds that modify the activity of discrete molecular targets. The molecular target approach to drug screening is widely used in th
Externí odkaz:
https://doaj.org/article/a0a33e021a6c4ac7b23faf18f18f6985
Autor:
Takahiko Shimizu, Isao Shimokawa
Publikováno v:
Translational Medicine of Aging, Vol 1, Iss , Pp 52-53 (2017)
Externí odkaz:
https://doaj.org/article/7a0ae66d03ee4c72901fb47ff4d79b8d
Autor:
Sayaka Akieda-Asai, Nobuhiro Zaima, Koji Ikegami, Tomoaki Kahyo, Ikuko Yao, Takahiro Hatanaka, Shun-Ichiro Iemura, Rika Sugiyama, Takeaki Yokozeki, Yoshinobu Eishi, Morio Koike, Kyoji Ikeda, Takuya Chiba, Haruyoshi Yamaza, Isao Shimokawa, Si-Young Song, Akira Matsuno, Akiko Mizutani, Motoji Sawabe, Moses V Chao, Masashi Tanaka, Yasunori Kanaho, Tohru Natsume, Haruhiko Sugimura, Yukari Date, Michael W McBurney, Leonard Guarente, Mitsutoshi Setou
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11755 (2010)
BACKGROUND: SIRT1, a NAD-dependent deacetylase, has diverse roles in a variety of organs such as regulation of endocrine function and metabolism. However, it remains to be addressed how it regulates hormone release there. METHODOLOGY/PRINCIPAL FINDIN
Externí odkaz:
https://doaj.org/article/058e2cab7c54476c87f498a588a61b8b
Autor:
Kazuaki Tajima, Nobuyoshi Fukushima, Keishi Kira, Masaaki Togo, Masashi Shibata, Shogo Mawatari, Hiroko Hayashi, Isao Shimokawa, Fuminao Takeshima, Kazuhiko Nakao
Publikováno v:
Kanzo. 63:77-86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6fe772985a4d6a07bff12571d850e1a
https://doi.org/10.2957/kanzo.63.77
https://doi.org/10.2957/kanzo.63.77
Autor:
Yukari Watanabe, Motoyasu Satou, Zi Wang, Yoshihisa Ohata, Seongjoon Park, Takuya Chiba, Toshimitsu Komatsu, Yoshitaka Kondo, Yiwen Yuan, Isao Shimokawa, Yuki Yoshii, Ryoichi Mori
Publikováno v:
Geriatrics & Gerontology International. 20:238-247
Aim Caloric restriction (CR), which limits the caloric intake to 60-70% of ad libitum (AL) amounts in various experimental animals, delays aging and extends the lifespan. We previously showed that neuropeptide Y (NPY), an appetite-stimulating peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a20169c92fab1570e770b52ceb84cdd
https://doi.org/10.1111/ggi.13848
https://doi.org/10.1111/ggi.13848
Publikováno v:
Biomedicines; Volume 9; Issue 11; Pages: 1739
Biomedicines
Biomedicines, Vol 9, Iss 1739, p 1739 (2021)
Biomedicines
Biomedicines, Vol 9, Iss 1739, p 1739 (2021)
Obesity is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), which is initiated by adipocyte-macrophage crosstalk. Among the possible molecules regulating this crosstalk, we focused on neuropeptide Y (NPY), which is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987f573b306f7c5cae0cd313ef73385a