Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Isao Sakane"'
Autor:
Udin Bahrudin, Masaki Unno, Kazuya Nishio, Akiko Kita, Peili Li, Masaru Kato, Masashi Inoue, Shunichi Tsujitani, Takuto Murakami, Rina Sugiyama, Yasushi Saeki, Yuji Obara, Keiji Tanaka, Hiroshi Yamaguchi, Isao Sakane, Yasushi Kawata, Toshiyuki Itoh, Haruaki Ninomiya, Ichiro Hisatome, Yukio Morimoto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibi
Externí odkaz:
https://doaj.org/article/f5cdc61bc8ea4f0a8fc5652c9651c68c
Autor:
Yasushi Kawata, Isao Sakane, Keiji Tanaka, Peili Li, Hiroshi Yamaguchi, Udin Bahrudin, Yuji Obara, Masaki Unno, Haruaki Ninomiya, Yasushi Saeki, Toshiyuki Itoh, Kazuya Nishio, Ichiro Hisatome, Akiko Kita, Masashi Inoue, Yukio Morimoto, Takuto Murakami, Rina Sugiyama, Shunichi Tsujitani, Masaru Kato
Publikováno v:
Scientific Reports
Bahrudin Udin, Unno Masaki, Nishio Kazuya, et al. Inhibitory effects of local anesthetics on the proteasome and their biological actions. SCIENTIFIC REPORTS. 2017. 7. doi:10.1038/s41598-017-04652-2
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Bahrudin Udin, Unno Masaki, Nishio Kazuya, et al. Inhibitory effects of local anesthetics on the proteasome and their biological actions. SCIENTIFIC REPORTS. 2017. 7. doi:10.1038/s41598-017-04652-2
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a2c8283c265689ba74a2b7c2f58965
https://doi.org/10.1038/s41598-017-04652-2
https://doi.org/10.1038/s41598-017-04652-2
Autor:
Hisashi Yagi, Naomi Ito, Tomohiro Mizobata, Yuji Goto, Shiho Ogawa, Kunihiro Hongo, Yasushi Kawata, Isao Sakane, Hideki Takeuchi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:2077-2087
alpha-Synuclein is one of the causative proteins of the neurodegenerative disorder, Parkinson's disease. Deposits of alpha-synuclein called Lewy bodies are a hallmark of this disorder, which is implicated in its progression. In order to understand th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50fd4d46073f16658b80d9f14b3b2f8
https://doi.org/10.1016/j.bbapap.2010.07.007
https://doi.org/10.1016/j.bbapap.2010.07.007
Autor:
Masahiko Kobayashi, Ken Ichi Yamamoto, Milena Popova, Naoyuki Hayashi, Ashok R. Venkitaraman, Masayuki Takahashi, Isao Sakane, Hitoshi Kurumizaka, Fabrice Fleury, Hiroko Shimizu
Publikováno v:
Biochemical and Biophysical Research Communications. 382:286-291
金沢大学がん研究所がん分子細胞制御
The assembly of RAD51 recombinase on DNA substrates at sites of breakage is essential for their repair by homologous recombination repair (HRR). The signaling pathway that triggers RAD51 assemb
The assembly of RAD51 recombinase on DNA substrates at sites of breakage is essential for their repair by homologous recombination repair (HRR). The signaling pathway that triggers RAD51 assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b0e8990418882ec4fe05f32ba538c5
https://doi.org/10.1016/j.bbrc.2009.03.020
https://doi.org/10.1016/j.bbrc.2009.03.020
Publikováno v:
Biophysics
Experimental probing of a protein-folding energy land-scape can be challenging, and energy landscapes comprising multiple intermediates have not yet been defined. Here, we quasi-statically unfolded single molecules of staphylococcal nuclease by const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0571a54844bfd74379e40f6dd283d4
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100592397
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100592397
Autor:
Hitoshi Kurumizaka, Chiaki Kamataki, Marina Nakashima, Yoshimasa Takizawa, Shukuko Ikawa, Takehiko Shibata, Hiroaki Ichikawa, Isao Sakane, Seiichi Toki
Publikováno v:
Nucleic Acids Research
The DMC1 protein, a meiosis-specific DNA recombinase, catalyzes strand exchange between homologous chromosomes. In rice, two Dmc1 genes, Dmc1A and Dmc1B, have been reported. Although the Oryza sativa DMC1A protein has been partially characterized, ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739f91b2b11618e6f20330abc1c6ccef
http://europepmc.org/articles/PMC2490746
http://europepmc.org/articles/PMC2490746
Publikováno v:
Genes to Cells. 13:91-103
The Rad51 protein, which catalyzes homologous-pairing and strand-exchange reactions, is an essential enzyme for homologous recombinational repair (HRR) and meiotic homologous recombination in eukaryotes. In humans, the conventional Rad51 (HsRad51) pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97e1d72244a77a07568ab2dbcfccbded
https://doi.org/10.1111/j.1365-2443.2007.01143.x
https://doi.org/10.1111/j.1365-2443.2007.01143.x
Autor:
Kunihiro Hongo, Tomohiro Mizobata, Fumihiro Motojima, Shigeto Murayama, Yasushi Kawata, Isao Sakane
Publikováno v:
Journal of Molecular Biology. 367:1171-1185
In order to understand how inter-subunit association stabilizes oligomeric proteins, a single polypeptide chain variant of heptameric co-chaperonin GroES (tandem GroES) was constructed from Escherichia coli heptameric GroES by linking consecutively t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2201643e4754244d425f78d8d08e798
https://doi.org/10.1016/j.jmb.2007.01.037
https://doi.org/10.1016/j.jmb.2007.01.037
Autor:
Yasushi Kawata, Isao Sakane, Yoshiko Hoshikawa, Kazuhiko Iitsuka, Haruaki Ninomiya, Osamu Igawa, Masaru Kato, Yasutaka Yamamoto, Junichiro Miake, Kazuyoshi Ogura, Ichiro Hisatome, Norihito Sasaki
Publikováno v:
Japanese Journal of Electrocardiology. 25:502-516
Na+チャネル遮断薬ピルジカイニド (Pil) がKv1.5チャネル蛋白を含む半減期の短い蛋白の増加作用を有することを見出したので, その機序をリドカイン (Lido) と比較して報告する.PilとLidoはプ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::185f54d7f8686d41bff9bfc322fa0676
https://doi.org/10.5105/jse.25.502
https://doi.org/10.5105/jse.25.502
Autor:
Chiduru Matsumoto, Katsuaki Inoue, Mitsuyoshi Ikeda, Takashi Higurashi, Kunihiro Hongo, Yasushi Kawata, Isao Sakane, Tomohiro Mizobata
Publikováno v:
Journal of Molecular Biology. 344:1123-1133
Chaperonin 10 (cpn10) is a well-conserved subgroup of the molecular chaperone family. GroES, the cpn10 from Escherichia coli, is composed of seven 10kDa subunits, which form a dome-like oligomeric ring structure. From our previous studies, it was fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02ccce4f1c7acd5cebd9599188e3fb3
https://doi.org/10.1016/j.jmb.2004.09.082
https://doi.org/10.1016/j.jmb.2004.09.082