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of 675
pro vyhledávání: '"Isao Karube"'
Publikováno v:
Analytical Letters. 52:1258-1267
Hemi-methylated DNA is double stranded (ds)DNA where only one of the complementary strands is methylated. Hemi-methylated DNA levels on a tandem repeat NBL2 and Sat2 are increased in ovarian carcinomas. To quantify hemi-methylation levels, a bisulfit
Publikováno v:
Analytical Letters. 52:754-760
DNA methylation is an epigenetic modification that represses gene expression. In cancer cells, alterations of the DNA methylation state in promoter regions and repetitive DNA sequences are ...
Publikováno v:
Principles and Applications of Quinoproteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7e9a49b94f0ea4044480025180412f
https://doi.org/10.1201/9781003067009-20
https://doi.org/10.1201/9781003067009-20
Publikováno v:
Analytica Chimica Acta. 990:168-173
Global DNA methylation levels have been considered as biomarkers for cancer diagnostics because transposable elements that constitute approximately 45% of the human genome are hypomethylated in cancer cells. We have previously reported a homogeneous
Autor:
Gérald Thouand, Shimshon Belkin, Sylvia Daunert, Paul Freemont, Julie Hermans, Isao Karube, Sylvain Martel, Elisa Michelini, Aldo Roda
This handbook is an interdisciplinary and comprehensive reference covering all aspects of cell biosensors. It is divided into four main sections which are led and organized by numerous international experts. The scope of coverage includes: Fundamenta
Akademický článek
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Publikováno v:
Analytical Chemistry. 88:9264-9268
DNA methylation plays an important role in the regulation of gene expression. In normal cells, transposable elements that constitute approximately 45% of the human genome are highly methylated to silence their expression. In cancer cells, transposabl
Publikováno v:
Handbook of Cell Biosensors ISBN: 9783319474052
Handbook of Cell Biosensors
Handbook of Cell Biosensors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8b012e349c61fa473fac5baea5e314
https://doi.org/10.1007/978-3-319-47405-2_95-1
https://doi.org/10.1007/978-3-319-47405-2_95-1
Autor:
Kazuo Nagasawa, Wataru Yoshida, Kazunori Ikebukuro, Isao Karube, Hitomi Yoshioka, Daniyah Habiballah Bay, Keisuke Iida
Publikováno v:
Analytical Chemistry. 88:7101-7107
DNA methylation has been proposed as one of the promising biomarkers for cancer diagnosis. In this study, we developed a DNA methylation detection system utilizing G-quadruplex and i-motif-forming sequences that requires neither sodium bisulfite trea
Autor:
Isao Karube, Hiroki Saikyo, Kazunori Ikebukuro, Kenichiro Hata, Wataru Yoshida, Keisuke Iida, Kazuhiko Nakabayashi, Daniyah Habiballah Bay, Hitomi Yoshioka, Tomoko Kawai, Kazuo Nagasawa
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
G-quadruplex (G4) is a DNA secondary structure that has been found to play regulatory roles in the genome. The identification of G4-forming sequences is important to study the specific structure-function relationships of such regions. In the present