Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Isao Ishii"'
Autor:
Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 624 (2024)
Three peroxisome proliferator-activated receptor subtypes, PPARα, PPAR(ß/)δ, and PPARγ, exert ligand-dependent transcriptional control in concert with retinoid X receptors (RXRs) on various gene sets harboring PPAR response elements (PPREs) in th
Externí odkaz:
https://doaj.org/article/e0100f18dab94f4cb159c0659b44680b
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 932 (2024)
One of the major global health and welfare issues is the treatment of obesity and associated metabolic disorders, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease. Obesity, caused by the excessive accumulation of triglycerides in
Externí odkaz:
https://doaj.org/article/be17a0c4b6c14bc48023941446327290
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13650 (2023)
Hydrogen sulfide (H2S), synthesized by cystathionine gamma-lyase (Cth), contributes to the inflammatory response observed in sepsis. This study examines the effect of Cth-derived H2S in adhesion molecules on endothelial cells of vital organs in mice
Externí odkaz:
https://doaj.org/article/67c33a2e43414fccb79485ef48e2ece4
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1264 (2023)
The number of patients with nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is increasing globally and is raising serious concerns regarding the increasing medical and economic burden incurred for their treatment. The pro
Externí odkaz:
https://doaj.org/article/1c08f3f259e84fa99d6471d3aa221987
Autor:
Junya Suzuki, Yuuki Shimizu, Takumi Hayashi, Yiyang Che, Zhongyue Pu, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, Isao Ishii, John W. Calvert, Toyoaki Murohara
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 21 (2022)
Background Accumulating evidence suggests that hydrogen sulfide ( H2S ), an endogenously produced gaseous molecule, plays a critical role in the regulation of cardiovascular homeostasis. However, little is known about its role in lymphangiogenesis. T
Externí odkaz:
https://doaj.org/article/51e04ef600904c6890179a0aae21a0bc
Autor:
Shotaro Kamata, Akihiro Honda, Ryo Ishikawa, Makoto Akahane, Ayane Fujita, Chihiro Kaneko, Saeka Miyawaki, Yuki Habu, Yui Shiiyama, Kie Uchii, Yui Machida, Takuji Oyama, Isao Ishii
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1523 (2023)
No therapeutic drugs are currently available for nonalcoholic steatohepatitis (NASH) that progresses from nonalcoholic fatty liver via oxidative stress-involved pathways. Three cognate peroxisome proliferator-activated receptor (PPAR) subtypes (PPAR
Externí odkaz:
https://doaj.org/article/0accaf46209a47e383198c9c9eddc003
Autor:
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 868 (2023)
Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals. Various forms of reactive persulfides
Externí odkaz:
https://doaj.org/article/b737ee93d096493aa67c2beef592f38f
Autor:
Isao Ishii, Madhav Bhatia
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4931 (2023)
The Special Issue “Amino Acid Metabolism and Regulation in Health and Disease 2 [...]
Externí odkaz:
https://doaj.org/article/5e244e65e7b04e1687fe0b51b5062b34
Autor:
Noriyuki Akahoshi, Ryoka Hasegawa, Shingo Yamamoto, Rintaro Takemoto, Toshiki Yoshizawa, Waka Kamichatani, Isao Ishii
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2659 (2023)
Hydrogen sulfide (H2S) has been shown to act as both anti-inflammatory and pro-inflammatory mediators. Application of H2S donors generally protects against inflammation; however, experimental results using mice lacking endogenous H2S-producing enzyme
Externí odkaz:
https://doaj.org/article/d04567bb7f4d44d2a5893ffa4c645260
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100364- (2021)
Summary: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor-type transcription factors with three subtypes (α, δ, and γ) that regulate cell differentiation and metabolism. Co-crystals of human PPARα-ligand-binding domain (LB
Externí odkaz:
https://doaj.org/article/53ce7e7731544411be941c2d5ade6d26