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pro vyhledávání: '"Isao Imperial Higashihak Umeda"'
Autor:
Mika Endo, Kazuko Kobayashi, Chikako Murasaki, Kenji Morikami, Kotaro Ogawa, Nobuo Shimma, Eitaro Nanba, Yoko Miyazaki, Isao Imperial Higashihak Umeda, Kiyoshi Yoshinari, Hiroshi Fukuda, Masako Ura, Satoshi Niizuma, Hitomi Suda, Takeshi Murata, Hisafumi Okabe, Tsuyoshi Takasuka, Jun Ohwada, Sawako Ozawa, Akira Kawashima, Hiromi Tanimura, Kounosuke Nakano, Masami Kohchi, Masao Tsukazaki
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(7)
Novel hexacyclic camptothecin analogs containing cyclic amidine, urea, or thiourea moiety were designed and synthesized based on the proposed 3D-structure of the topoisomerase I (Topo I)/DNA/camptothecin ternary complex. The analogs were prepared fro