Výsledky vyhledávání - "Isao Hiraoka"

Infertility Observed in Reproductive Toxicity Study of N-Acetyl-l-Cysteine in Rats

Autor: Yoshiro Kawaguchi, Tadakazu Furuhashi, Yoshifumi Nakashima, Koji Kishimoto, Miwa Harada, Kazuyosi Naito, Isao Hiraoka

Publikováno v: Biology of Reproduction. 69:242-247

The toxic effects of i.v. administration of N-acetyl-l-cysteine (NAC), a component of parenteral nutrition solutions, on fertility and embryonic development were investigated in SD male and female rats at doses of 100, 300, and 1000 mg kg-1 day-1. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213ae426ea967f459c2917ff8f2815b2
https://doi.org/10.1095/biolreprod.102.013862

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Autor: Isao Hiraoka, Shinsaku Naito, Daisuke Harada, Masaki Otagiri

Publikováno v: Pharmaceutical Research. 19:615-620

Purpose. This investigation was undertaken to study the relationship between plasma drug clearance and covalent protein-binding kinetics of N-acetyl-L-cysteine (NAC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c11a774f32d6899abbe9fffce27f0a95
https://doi.org/10.1023/a:1015349928000

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Determination of Reduced, Protein-Unbound, and Total Concentrations of N-Acetyl--cysteine and -Cysteine in Rat Plasma by Postcolumn Ligand Substitution High-Performance Liquid Chromatography

Autor: Yoshiyuki Kawauchi, Daisuke Harada, Isao Hiraoka, Shinsaku Naito, Osamu Koshitani, Keiko Ishikawa, Masaki Otagiri

Publikováno v: Analytical Biochemistry. 290:251-259

A high-performance liquid chromatographic assay was developed for the quantitative determination of the sulfur-containing amino acids N-acetyl-L-cysteine (NAC) and L-cysteine (Cys) in rat plasma. The thiols were separated by reverse-phase ion-pair ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6e0bc21861c74f06fc38853173236d
https://doi.org/10.1006/abio.2000.4980

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Culture Supernatants ofLactobacillus acidophilusandBifidobacterium adolescentisRepress Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug by Suppressing Unbalanced Growth of Aerobic Bacteria and Lipid Peroxidation

Autor: Isao Hiraoka, Tomomi Kuwahara, Yoshinari Ohnishi, Shan Ruo Bing, Motoo Uejima, Takemi Kinouchi, Shigeru Akimoto, Haruyuki Nakayama, Keiko Kataoka, Kazuyuki Shimono

Publikováno v: Microbiology and Immunology. 42:347-355

A nonsteroidal antiinflammatory drug, 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl) thiophene (BFMeT), induced ileal ulcers in rats after oral administration, while no ulcers were observed after subcutaneous injection. The ileal ulcer formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cbdfe36e23d9411d274938eb1f9a2f
https://doi.org/10.1111/j.1348-0421.1998.tb02294.x

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Role of Intestinal Bacteria in Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug

Autor: Takemi Kinouchi, Yoshinari Ohnishi, Keiko Kataoka, Motoo Uejima, Isao Hiraoka

Publikováno v: Microbiology and Immunology. 40:553-560

The role of intestinal bacteria in induction and repression of ulcer formation in the ileum of rats treated with one of the nonsteroidal antiinflammatory drugs (NSAIDs), 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl) thiophene (BFMeT), was exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f201a89aacfb69f0376c012418d151
https://doi.org/10.1111/j.1348-0421.1996.tb01108.x

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In vivo kinetic analysis of covalent binding between N-acetyl-L-cysteine and plasma protein through the formation of mixed disulfide in rats

Autor: Daisuke, Harada, Shinsaku, Naito, Isao, Hiraoka, Masaki, Otagiri

Publikováno v: Pharmaceutical research. 19(5)

This investigation was undertaken to study the relationship between plasma drug clearance and covalent protein-binding kinetics of N-acetyl-L-cysteine (NAC).NAC was intravenously administered to rats via a bolus injection or continuous infusion. Plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5d0e816d68b8a2391912744377c996b
https://pubmed.ncbi.nlm.nih.gov/12069163

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Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR

Autor: Isao Hiraoka, Hiroki Yoshitsugu, Masuhiro Nishimura, Shinsaku Naito

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 122(5)

In the present study, the induction of drug-metabolizing enzymes and transporters was evaluated by analyzing mRNA expression in human hepatocytes after exposure to various compounds. The compounds tested included typical enzyme inducers, rifampicin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ca3416cf650a3f1a06e22bd1b51162
https://pubmed.ncbi.nlm.nih.gov/12040753

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Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine

Autor: Isao Hiraoka, Kiyoshi Mukai, Satoru Moriguchi, Yasuo Kishino

Publikováno v: Nutrition Research. 7:719-729

Human lymphocytes and monocytes obtained from healthy nonsmoking volunteers, were activated by in vitro incubation with excess arginine. Natural killer cell (NK) activity was increased three-fold after in vitro incubation with 64×102μg/ml of argini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6ba0209b3d43239ffcfe9248a04e436
https://doi.org/10.1016/s0271-5317(87)80102-1

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