Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Isao Hasegawa"'
Autor:
Yuki Katayama, MD, PhD, Tadaaki Yamada, MD, PhD, Kenji Morimoto, MD, PhD, Hiroyuki Fujii, MD, Satomi Morita, MD, PhD, Keiko Tanimura, MD, PhD, Takayuki Takeda, MD, PhD, Asuka Okada, MD, PhD, Shinsuke Shiotsu, MD, PhD, Yusuke Chihara, MD, PhD, Osamu Hiranuma, MD, Takahiro Yamada, MD, PhD, Takahiro Ota, MD, PhD, Taishi Harada, MD, Isao Hasegawa, MD, PhD, Masahiro Iwasaku, MD, PhD, Shinsaku Tokuda, MD, PhD, Noriyuki Tanaka, MD, PhD, Aya Miyagawa-Hayashino, MD, PhD, Koichi Takayama, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 3, Pp 100644- (2024)
Introduction: Multiple programmed death-ligand 1 (PD-L1) immunohistochemistry assays performed using different antibodies including DAKO 22C3, DAKO 28-8, and Ventana SP142 PD-L1—predictive markers for response to various immune checkpoint inhibitor
Externí odkaz:
https://doaj.org/article/3964141379334812bbe15faf7291e902
Autor:
Shota Takei, Hayato Kawachi, Tadaaki Yamada, Motohiro Tamiya, Yoshiki Negi, Yasuhiro Goto, Akira Nakao, Shinsuke Shiotsu, Keiko Tanimura, Takayuki Takeda, Asuka Okada, Taishi Harada, Koji Date, Yusuke Chihara, Isao Hasegawa, Nobuyo Tamiya, Yuki Katayama, Naoya Nishioka, Kenji Morimoto, Masahiro Iwasaku, Shinsaku Tokuda, Takashi Kijima, Koichi Takayama
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe proportion of older patients diagnosed with advanced-stage non-small cell lung cancer (NSCLC) has been increasing. Immune checkpoint inhibitor (ICI) monotherapy (MONO) and combination therapy of ICI and chemotherapy (COMBO) are standa
Externí odkaz:
https://doaj.org/article/0523905fe5d04548b83c0aeba67c60f5
Autor:
Yosuke Muranaka, Taisuke Maki, Isao Hasegawa, Hiroyuki Nakagawa, Ryutaro Kubota, Ryoma Kaji, Kazuhiro Mae
Publikováno v:
Journal of Chemical Engineering of Japan, Vol 56, Iss 1 (2023)
The synthesis of fatty acid methyl ester from soybean oil was examined. A microreactor was used as a reactor, and the results were compared with those by batch reaction. In a batch reaction experiment, the concentration of by-product glycerol was lar
Externí odkaz:
https://doaj.org/article/e20540bdef8b4b44b9bdd42f274658b4
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113169- (2023)
Summary: Interaction between the inferotemporal (ITC) and prefrontal (PFC) cortices is critical for retrieving information from memory and maintaining it in working memory. Neural oscillations provide a mechanism for communication between brain regio
Externí odkaz:
https://doaj.org/article/923f2eab1be44a22b572f4a0932e7722
Autor:
Yuki Katayama, MD, Tadaaki Yamada, MD, PhD, Kenji Morimoto, MD, PhD, Hiroyuki Fujii, MD, Satomi Morita, MD, Keiko Tanimura, MD, PhD, Takayuki Takeda, MD, PhD, Asuka Okada, MD, PhD, Shinsuke Shiotsu, MD, PhD, Yusuke Chihara, MD, PhD, Osamu Hiranuma, MD, Takahiro Yamada, MD, PhD, Takahiro Ota, MD, PhD, Taishi Harada, MD, Isao Hasegawa, MD, PhD, Akihiro Yoshimura, MD, PhD, Masahiro Iwasaku, MD, PhD, Shinsaku Tokuda, MD, PhD, Young Hak Kim, MD, PhD, Koichi Takayama, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 4, Pp 100494- (2023)
Introduction: Lung adenocarcinoma with negative TTF-1 expression is believed to be a poor prognostic factor for certain systemic treatments. Nevertheless, the impact of TTF-1 expression on combined chemoimmunotherapy remains unclear. We aimed to inve
Externí odkaz:
https://doaj.org/article/f5a29b79c158468da31bfa4f00a93ada
Autor:
Nanxi Liu, Atsuhiko Iijima, Yutaka Iwata, Kento Ohashi, Nobuyoshi Fujisawa, Toshikuni Sasaoka, Isao Hasegawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract When writing an object’s name, humans mentally construct its spelling. This capacity critically depends on use of the dual-structured linguistic system, in which meaningful words are represented by combinations of meaningless letters. Here
Externí odkaz:
https://doaj.org/article/875028724bf644faad677970e17b3bff
Autor:
Shinsuke Shiotsu, Akihiro Yoshimura, Tadaaki Yamada, Kenji Morimoto, Michiko Tsuchiya, Hiroshige Yoshioka, Osamu Hiranuma, Yusuke Chihara, Takahiro Yamada, Isao Hasegawa, Takahiro Ohta, Takayuki Takeda, Noriya Hiraoka, Koichi Takayama
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectivesWe investigated the efficacy and safety of pembrolizumab monotherapy as first-line treatment for poor Eastern Cooperative Oncology Group performance status (PS) and elderly patients with programmed cell death-ligand 1 (PD-L1)-positive advan
Externí odkaz:
https://doaj.org/article/70e4a1568c644994b748777d7b9b5168
Autor:
Kenji Morimoto, MD, PhD, Ryo Sawada, MD, Tadaaki Yamada, MD, PhD, Koichi Azuma, MD, PhD, Kentaro Ito, MD, Yasuhiro Goto, MD, PhD, Hideharu Kimura, MD, PhD, Taishi Harada, MD, Shinsuke Shiotsu, MD, Nobuyo Tamiya, MD, PhD, Yusuke Chihara, MD, PhD, Takayuki Takeda, MD, PhD, Osamu Hiranuma, MD, Isao Hasegawa, MD, PhD, Yoshie Morimoto, MD, PhD, Masahiro Iwasaku, MD, PhD, Shinsaku Tokuda, MD, PhD, Koichi Takayama, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 9, Pp 100388- (2022)
Introduction: The use of immune checkpoint inhibitors (ICIs) with chemotherapy has increased the survival of patients with advanced NSCLC. Nevertheless, the efficacy of ICI treatment for NSCLC with EGFR mutations is limited. Previous studies have not
Externí odkaz:
https://doaj.org/article/1e1fc663904a4f5abcb4031e0440a538
Autor:
Yuki Suda, Mariko Tada, Takeshi Matsuo, Keisuke Kawasaki, Takeshi Saigusa, Maho Ishida, Tetsuo Mitsui, Hironori Kumano, Kenji Kirihara, Takafumi Suzuki, Kenji Matsumoto, Isao Hasegawa, Kiyoto Kasai, Takanori Uka
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Sensory prediction is considered an important element of mismatch negativity (MMN) whose reduction is well known in patients with schizophrenia. Omission MMN is a variant of the MMN which is elicited by the absence of a tone previously sequentially p
Externí odkaz:
https://doaj.org/article/8d4ca64819d04e5587c46baf1cb3e848
Autor:
Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Episodic or declarative memory is thought to be encoded in the ensemble firing of spatially distributed neurons. Here the authors use high-density electrical recordings to show that some areas in the primate temporal cortex develop patterns of theta
Externí odkaz:
https://doaj.org/article/61ddec2daffe427ebbcdfc5acad9fe90