Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Isao, Shimizu"'
Autor:
Shogo Haraguchi, Masaki Kamata, Takuma Tokita, Kei-ichiro Tashiro, Miku Sato, Mitsuki Nozaki, Mayumi Okamoto-Katsuyama, Isao Shimizu, Guofeng Han, Vishwajit Sur Chowdhury, Xiao-Feng Lei, Takuro Miyazaki, Joo-ri Kim-Kaneyama, Tomoya Nakamachi, Kouhei Matsuda, Hirokazu Ohtaki, Toshinobu Tokumoto, Tetsuya Tachibana, Akira Miyazaki, Kazuyoshi Tsutsui
Publikováno v:
eLife, Vol 8 (2019)
The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activ
Externí odkaz:
https://doaj.org/article/6d5dc4206ed54013a89ce2ae2cf2ab80
Autor:
Katsuaki Ieguchi, Takeshi Tomita, Toshifumi Takao, Tsutomu Omori, Taishi Mishima, Isao Shimizu, Massimiliano Tognolini, Alessio Lodola, Takuya Tsunoda, Shinichi Kobayashi, Satoshi Wada, Yoshiro Maru
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2480 (2021)
Accumulating evidence indicates that an elevated ephrin-A1 expression is positively correlated with a worse prognosis in some cancers such as colon and liver cancer. The detailed mechanism of an elevated ephrin-A1 expression in a worse prognosis stil
Externí odkaz:
https://doaj.org/article/f2304fca56164d208500e15cba0cc1f6
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 2, Pp 164-167 (2014)
Abstract.: Patients with psychiatric disorders, including schizophrenia, are reported to suffer from sleep disorders. In this study, we investigated the effects of lurasidone, an atypical antipsychotic, on sleep architecture in rats using sleep elect
Externí odkaz:
https://doaj.org/article/0e6b5d0e100f47be93cc89aa69478845
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 4, Pp 415-423 (2009)
Abstract.: Polyethylene glycol electrolyte lavage solution (PEG-ELS) is widely used for colon cleansing prior to colonoscopy and colonic surgery. It has recently been shown that coadministration of PEG-ELS and mosapride citrate hydrate (mosapride), a
Externí odkaz:
https://doaj.org/article/3a65bd988bb74c5bab7fbe12d3ba4802
Publikováno v:
European Journal of Pharmacology. 830:26-32
Long-term treatment with antipsychotic drugs in patients with schizophrenia can lead to dopamine supersensitivity psychosis. It is reported that repeated administration of haloperidol caused dopamine supersensitivity in rats. Blonanserin is an atypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2855a1bef0c533bf8f197bd3335d83
https://doi.org/10.1016/j.ejphar.2018.04.014
https://doi.org/10.1016/j.ejphar.2018.04.014
Publikováno v:
European Journal of Pharmacology. 826:123-132
The pharmacological profile of DSP-6952, a novel 5-HT4 receptor partial agonist, was investigated to evaluate the potential use for GI disorders, and to compare its effects in some GI dysfunction models with those of clinically efficacious prokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1121b3bcf8d021b00c3b2da869a65f42
https://doi.org/10.1016/j.ejphar.2018.02.005
https://doi.org/10.1016/j.ejphar.2018.02.005
Autor:
Akihiko Kiyoshi, Isao Shimizu, Yasunori Katsura, Tadashi Tsubouchi, Kiyoko Bando, Seiko Oku, Shinji Tsujimoto, Toru Yamada, Kazuhiro Chihara, Yukiko Mine, Takeshi Kunimatsu
Publikováno v:
European Journal of Pharmacology. 826:96-105
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonists. DSP-6952 had a strong affinity of K i = 51.9 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::840f70dc774d7cf9b312025373d5c8ab
https://doi.org/10.1016/j.ejphar.2018.02.037
https://doi.org/10.1016/j.ejphar.2018.02.037
Autor:
Tetsuya Tachibana, Miku Sato, Takuro Miyazaki, Akira Miyazaki, Mayumi Okamoto-Katsuyama, Shogo Haraguchi, Mitsuki Nozaki, Joo-ri Kim-Kaneyama, Kazuyoshi Tsutsui, Hirokazu Ohtaki, Tomoya Nakamachi, Xiao-Feng Lei, Takuma Tokita, Toshinobu Tokumoto, Isao Shimizu, Vishwajit S. Chowdhury, Masaki Kamata, Kouhei Matsuda, Kei Ichiro Tashiro, Guofeng Han
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b63f3e657bdf04aebfdcf4ca1b28228
https://pubmed.ncbi.nlm.nih.gov/31566568
https://pubmed.ncbi.nlm.nih.gov/31566568
Autor:
Toshifumi Takao, Takuya Tsunoda, Satoshi Wada, Katsuaki Ieguchi, Taishi Mishima, Alessio Lodola, Tsutomu Omori, Yoshiro Maru, Massimiliano Tognolini, Shinichi Kobayashi, Takeshi Tomita, Isao Shimizu
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2480, p 2480 (2021)
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2480, p 2480 (2021)
Accumulating evidence indicates that an elevated ephrin-A1 expression is positively correlated with a worse prognosis in some cancers such as colon and liver cancer. The detailed mechanism of an elevated ephrin-A1 expression in a worse prognosis stil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb29dfee1cc58c593afd3295caf210b8
https://doi.org/10.3390/ijms22052480
https://doi.org/10.3390/ijms22052480
Autor:
Mayumi Okamoto, Kiichi Ishiwata, Jun Toyohara, Hiromitsu Shibayama, Kyosuke Naka, Isao Shimizu, Yuya Kitagawa
Publikováno v:
Nuclear Medicine and Biology. 43:512-519
Introduction Several lines of evidence suggest that 7α-substituted estradiol derivatives bind to the estrogen receptor (ER). In line with this hypothesis, we designed and synthesized 18 F-labeled 7α-fluoroalkylestradiol (Cn-7α-[ 18 F]FES) derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8983363c75931c0e41964e2fe0d3106
https://doi.org/10.1016/j.nucmedbio.2016.05.008
https://doi.org/10.1016/j.nucmedbio.2016.05.008