Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Isamu Sugawara"'
Autor:
Yukiko Kuroda, Kenta Maruyama, Hideki Fujii, Isamu Sugawara, Shigeru B H Ko, Hisataka Yasuda, Hidenori Matsui, Koichi Matsuo
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146544 (2016)
Osteoprotegerin (OPG), a decoy receptor for receptor activator of NF-κB ligand (RANKL), antagonizes RANKL's osteoclastogenic function in bone. We previously demonstrated that systemic administration of lipopolysaccharide (LPS) to mice elevates OPG l
Externí odkaz:
https://doaj.org/article/c7fe118a43da431faca26153b807a1b0
Autor:
Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000643 (2009)
In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown. In a previous study, we found that mycobacteria interact with hyaluronan on lung epitheli
Externí odkaz:
https://doaj.org/article/bb891b8d5122440bae8698593bf76639
Autor:
Satoshi Omura, Hirofumi Inagaki, Takako Shimizu, Hajime Takizawa, Shoji Kudoh, Tomoyuki Kawada, Ying-Ji Li, Toshiaki Sunazuka, Yukiyo Hirata, Isamu Sugawara, Arata Azuma
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 26:318-324
Diesel exhaust particle (DEP) is the major components of PM2.5, and much attention has focused on PM2.5 in relation to adverse health effects, and many pulmonary diseases. In the present study, we used a human bronchial epithelial cell (HBEC) line to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905988faa3964d23cc8ae688022037f9
https://doi.org/10.1016/j.pupt.2012.12.010
https://doi.org/10.1016/j.pupt.2012.12.010
Autor:
Saburo Yamamoto, Ikuya Yano, Kenji Iwama, Tadashi Udagawa, Ikuro Honda, Akira Hashimoto, Isamu Sugawara, Masaaki Seki, Isao Fujita
Publikováno v:
Vaccine. 30:1460-1464
Many genetic differences have been found among currently available BCG vaccines. To avoid continued accumulation of phenotypic or genotypic changes in the strains, WHO and most national regulatory authorities request that the vaccine should not be pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9bcb2ec304e75a14c24c7881c9cedb
https://doi.org/10.1016/j.vaccine.2011.12.101
https://doi.org/10.1016/j.vaccine.2011.12.101
Publikováno v:
Inhalation Toxicology. 23:805-813
We investigated whether pre- and postnatal low-dose exposure to diesel exhaust (DE) affects male reproductive function in mice. The DE concentration is less than that indicated as the environmental quality standard for suspended particulate matter (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d922f0d1bfbb80ebdee9bb0363d5c
https://doi.org/10.3109/08958378.2011.610834
https://doi.org/10.3109/08958378.2011.610834
Autor:
Masayuki Yamamoto, Isamu Sugawara, Yasuhiro Yamauchi, Satoru Takahashi, Hajime Takizawa, Shoji Kudoh, Tomoyuki Kawada, Tadashi Kohyama, Ying-Ji Li, Arata Azuma
Publikováno v:
Clinical Immunology. 137:234-241
We have recently reported that disruption of nuclear erythroid 2 P45-related factor 2 (Nrf2) enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles (DEP) in mice. C57BL/6 Nrf2 knockout (Nrf2(-/-)) mice a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7af930fbadb92a216fbea2677c28f7
https://doi.org/10.1016/j.clim.2010.07.014
https://doi.org/10.1016/j.clim.2010.07.014
Autor:
Mayuko Osada-Oka, Yuji Nishiuchi, Nobuyuki Harada, Yoshitaka Tateishi, Sohkichi Matsumoto, Kazuo Kobayashi, Isamu Sugawara, Hajime Hisaeda, Toshiaki Aoki, Tadashi Udagawa, Yuriko Ozeki
Publikováno v:
International Immunology. 22:179-189
CD4(+)CD25(+) regulatory T (Treg) cells cause immune suppression by inhibiting T cell effector functions and play pivotal roles not only in self-tolerance but also in immune response to parasitic microbial pathogens. Mycobacteria are major parasitic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446163e76ee186a504332153928194b9
https://doi.org/10.1093/intimm/dxp126
https://doi.org/10.1093/intimm/dxp126
Autor:
Ruiru Shi, Isamu Sugawara
Publikováno v:
The Tohoku Journal of Experimental Medicine. 221:97-106
Mycobacterium tuberculosis, the causative agent of tuberculosis, is a tenacious and remarkably successful pathogen that has latently infected one third of the world's population, according to the World Health Organization (WHO) statistics. It is anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe99cd98589e45d3a3fe06f141b98e6d
https://doi.org/10.1620/tjem.221.97
https://doi.org/10.1620/tjem.221.97
Publikováno v:
The Tohoku Journal of Experimental Medicine. 219:257-262
There exists latent tuberculosis, in which small numbers of tubercle bacilli remain viable in the host without visible granulomatous lesions. As few data exist on the mechanisms of latent tuberculosis, it is important to examine latent tuberculosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2abe9bb996ed18bf3e0a46211f0cf7
https://doi.org/10.1620/tjem.219.257
https://doi.org/10.1620/tjem.219.257
Publikováno v:
Neuroscience Letters. 449:38-41
Diesel exhaust (DE) is composed of particles and gaseous compounds. It has been reported that DE causes pulmonary and cardiovascular disease. We have previously reported that fetal exposure to DE had deleterious effects to the reproductive system of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db880f39be004665ef5b9a63ca529643
https://doi.org/10.1016/j.neulet.2008.09.085
https://doi.org/10.1016/j.neulet.2008.09.085