Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Isamu Saikawa"'
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Studies on protein binding of antibiotics II. Effect of apalcillin on protein binding and pharmacokinetics of cefoperazone and cefazolin
Autor: Isamu Saikawa, Kihachiro Shimizu, Rieko Kitayama, Watanabe Yasuo, Yasuda Takashi, Toshio Hayashi
Publikováno v: The Journal of Antibiotics. 34:753-757
The drug-protein interactions between cefoperazone (CPZ) and apalcillin (APPC), and between cefazolin (CEZ) and APPC were investigated in in vitro and in vivo experiments. Through the binding rates of CPZ or CEZ to rabbit serum and human serum albumi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba08e7d483076069457b1f4567f5133
https://doi.org/10.7164/antibiotics.34.753
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6
Studies on protein binding of antibiotics. IV. Effect of the binding of drug to 100,000*g supernatant fluid of rabbit liver homogenates on urinary excretion
Autor: Kihachiro Shimizu, Masashi Noguchi, Isamu Saikawa, Rieko Kitayama, Toshio Hayashi, Nakashima Yoshifumi, Watanabe Yasuo, Yasuda Takashi
Publikováno v: The Journal of Antibiotics. 35:1603-1609
To characterize the effect of the binding of antibiotics to tissue protein on urinary excretion, we examined the extent of the binding of 9 penicillins and 9 cephems to 100,000 X g supernatant fluid of human liver homogenates. The correlation analysi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0292904a4659943287dae88259965cd
https://doi.org/10.7164/antibiotics.35.1603
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