Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Isamu Nanchi"'
Autor:
Masahiko Soga, Takaya Izumi, Isamu Nanchi, Narumi Horita, Miyuki Yamamoto, Shiori Kawasaki, Koichi Ogawa, Masahide Fujita, Yasuhide Morioka
Publikováno v:
PAIN Reports, Vol 6, Iss 3, p e951 (2021)
Abstract. Introduction:. Transient receptor potential vanilloid 4 (TRPV4) modulates osteoarthritic (OA) pain in animal models. However, the pathophysiological function of TRPV4 in regulating OA pain remains poorly understood. Methods:. We developed T
Externí odkaz:
https://doaj.org/article/766c588121364c85aee24badfea421d5
Autor:
Takanobu Matsuzaki, Takanori Akazawa, Tomohiko Okuda, Makoto Iwasaki, Yasuto Kido, Yasuyuki Fusamae, Kimiko Nishida, Eiichi Tsuchiya, Hiromi Sawada, Isamu Nanchi
Publikováno v:
Drug metabolism and pharmacokinetics. 42
The brain penetration of 19 drugs, including P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) substrates, was compared among mice, cynomolgus monkeys and beagle dogs. The brain-to-plasma concentration ratios (Kp,brain) of the test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0313fd35f7cf2511cdcf078fcdb5967
https://pubmed.ncbi.nlm.nih.gov/34974334
https://pubmed.ncbi.nlm.nih.gov/34974334
Autor:
Shiori Kawasaki, Sunao Imai, Isamu Nanchi, Masahide Fujita, Yasuhide Morioka, Toshiyuki Asaki
Publikováno v:
PAIN RESEARCH. 34:240-246
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32bd0be2a5cbdf22b357db84139f19b1
https://doi.org/10.11154/pain.34.240
https://doi.org/10.11154/pain.34.240
Autor:
Narumi Horita, Shiori Kawasaki, Masahiko Soga, Koichi Ogawa, Masahide Fujita, Takaya Izumi, Isamu Nanchi, Miyuki Yamamoto, Yasuhide Morioka
Publikováno v:
Pain Reports
PAIN Reports, Vol 6, Iss 3, p e951 (2021)
PAIN Reports, Vol 6, Iss 3, p e951 (2021)
Supplemental Digital Content is Available in the Text. Knee joint pain in osteoarthritis model rats is caused by the sensitization of transient receptor potential vanilloid 4 in the dorsal root ganglion neurons
Introduction: Transient receptor p
Introduction: Transient receptor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0951e3ec5c05714d5a4fdfba9aa31d9c
https://pubmed.ncbi.nlm.nih.gov/34396019
https://pubmed.ncbi.nlm.nih.gov/34396019
Autor:
Kumi Hashimoto, Atsuyuki Shimazaki, Isamu Nanchi, Hirohide Nambu, Hideo Yukioka, Hiroyuki Takagi, Yuto Kashiwagi, Tatsuya Ikehara
Publikováno v:
Endocrinology. 159:3007-3019
Intramyocellular lipid (IMCL) accumulation in skeletal muscle greatly contributes to lipid-induced insulin resistance. Because acetyl-coenzyme A (CoA) carboxylase (ACC) 2 negatively modulates mitochondrial fatty acid oxidation (FAO) in skeletal muscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62d1ba5203d3296acc696812b425647
https://doi.org/10.1210/en.2018-00338
https://doi.org/10.1210/en.2018-00338
Autor:
Takanori Iwasaki, Nobuteru Akiyama, Shogo Oka, Hideo Yukioka, Tomohiko Okuda, Kumiko Fujieda, Tetsuya Kouno, Isamu Nanchi
Publikováno v:
Peptides. 86:145-152
A close relationship between acylated-ghrelin and sucrose intake has been reported. However, little has been examined about the physiological action of ghrelin on preference for different types of carbohydrate such as glucose, fructose, and starch. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c64f6dd8cb46923b23249f6327eb18
https://doi.org/10.1016/j.peptides.2016.11.003
https://doi.org/10.1016/j.peptides.2016.11.003
Autor:
Sunao Imai, Isamu Nanchi, Naoki Tsuno, Yusuke Sakurai, Yasuhide Morioka, Miyuki Yamamoto, Shiori Kawasaki, Masahide Fujita, Masahiko Soga, Toshiyuki Asaki, Tatsuya Takahashi
Publikováno v:
European Journal of Pharmacology. 899:174040
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel activated by various physical stimuli such as cell swelling and shear stress. TRPV4 is expressed in bladder sensory nerves and epithelium, and its activation produces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680dc6a30140f62c94026bd1c0d06b87
https://doi.org/10.1016/j.ejphar.2021.174040
https://doi.org/10.1016/j.ejphar.2021.174040
Autor:
Nobuteru Akiyama, Shogo Oka, Isamu Nanchi, Tetsuya Kouno, Mitsuru Notoya, Hideo Yukioka, Tomohiko Okuda, Takahito Ito
Publikováno v:
Journal of Endocrinology. 228:115-125
Ghrelin is an appetite-stimulating hormone secreted from stomach. Since the discovery that acylation of the serine-3 residue by ghrelin O-acyltransferase (GOAT) is essential for exerting its functions, GOAT has been regarded as an therapeutic target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc642c1732e34328eeb840a83744ad21
https://doi.org/10.1530/joe-15-0330
https://doi.org/10.1530/joe-15-0330
Autor:
Nobuteru Akiyama, Hideo Yukioka, Isamu Nanchi, Tomohiko Okuda, Kumiko Fujieda, Mitsuru Notoya, Tetsuya Kouno, Takahito Ito, Takanori Iwasaki
Publikováno v:
Endocrine journal. 64
The octanoyl modification of ghrelin by ghrelin O-acyltransferase (GOAT) is essential for exerting its physiologic actions. Since exogenous acylated-ghrelin has shown to stimulate food intake in humans and rodents, GOAT has been regarded as a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c888d91823f1863ca8afbea52194ab
https://pubmed.ncbi.nlm.nih.gov/28652538
https://pubmed.ncbi.nlm.nih.gov/28652538
Autor:
Yoshifumi Shimizu, Hajime Maeda, Masashi Nakagawa, Haruo Sugiyama, Yusuke Oji, Akihiro Tsuboi, Sayaka Takagi, Meinoshin Okumura, Isamu Nanchi, Ikuyo Fukuda, Fumihiro Fujiki, Michiyo Nakamura, Syohei Shibata, Tetsuji Naka, Erika Hirata, Masayoshi Inoue, Hidenori Inohara, Naoya Tatsumi, Naoki Hosen, Yui Murakami, Yumiko Yamamoto, Takeshi Tomonaga, Sumiyuki Nishida, Eiichi Morii, Shin-ichi Nakatsuka, Mari Fukuda, Hiroko Nakajima, Tomoko Hoshikawa, Masahide Mori, Riichiro Nezu, Norio Nonomura, Kana Hasegawa, Junichi Hasegawa, Sayaka Aoyagi, Shuichi Izumoto, Yoshihiro Oka, Toshiki Yoshimine
Publikováno v:
International Journal of Oncology
Recent studies have shown that cancer immuno- therapy could be a promising therapeutic approach for the treatment of cancer. In the present study, to identify novel tumor-associated antigens (TAAs), the proteins expressed in a panel of cancer cells w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50cc4e60e245a2331039ec0abf74800
https://doi.org/10.3892/ijo.2014.2318
https://doi.org/10.3892/ijo.2014.2318