Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Isami Kimura"'
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:133-138
Publikováno v:
Ensho. 17:499-508
To clarify the mechanism of action of 5- [4- (2-carboxyethylcarbamoyl) -phenylazo] -salicylic acid disodium salt dehydrate (BX661A) as a therapeutic drug for ulcerative colitis, we investigated the effects on carrageenin edema, adjuvant arthritis, po
Autor:
Isami Kimura, Shinobu Nagahama, Hiroyuki Tanigawa, Junichi Yoshida, Akemi Kamiya, Mikiko Kataoka
Publikováno v:
Folia Pharmacologica Japonica. 102:343-350
We have developed a new method that is applicable for a macroscopic and objective evaluation of erosion in the large intestine in the experimental ulcerative colitis model induced by dextran sulfate sodium (DSS) in rats. The large intestine (without
Autor:
K. Uenishi, Y. Ishizuka, Hiroshi Shimamura, Makoto Sato, Isami Kimura, A. Kawase, Yukichi Tanaka, K. Terashima
Publikováno v:
ChemInform. 26
Autor:
K. Terashima, Hiroshi Shimamura, Makoto Sato, T. Tanimura, K. Uenishi, Isami Kimura, A. Kawase, T. Kamisaki, Yukichi Tanaka, Y. Ishizuka
Publikováno v:
ChemInform. 26
Publikováno v:
ChemInform. 30
Autor:
Tsunehisa Noto, Isami Kimura, Takashi Inui, Masaaki Nagasaki, Kayoko Okuyama, Ayako Watanable, Hiroshi Yamada
Publikováno v:
Digestive diseases and sciences. 50(5)
Ecabet, an antiulcer drug, is reported to be effective in patients with ulcerative colitis. We investigated the effect of ecabet enema on ulcerative colitis in rats and some mechanisms underlying this effect. In vivo ecabet enema showed a therapeutic
Autor:
Akito Kawase, Tanaka Yuji, Hiroshi Shimamura, Isami Kimura, Makoto Sato, Kohji Terashima, Yasuhiro Ishizuka, Keiji Uenishi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:166-168
Ethyl 2-[1H-benzimidazol-2-yl)sulfinylmethyl]-4-dimethylamino-5- pyrimidinecarboxylate (2) has been synthesized and evaluated for antiulcer properties. Compound 2 is a H+/K(+)-ATPase inhibitor that affords mucosal protection against absolute ethanol-
Autor:
Keiji Uenishi, Makoto Sato, Tanaka Yuji, Isami Kimura, Yasuhiro Ishizuka, Toshiaki Kamisaki, Kohji Terashima, Teru Tanimura, Akito Kawase, Hiroshi Shimamura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1042-1044
With the aim of applying mast cell-stabilizing agents as antiulcer agents, N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides were synthesized, and initially evaluated pharmacologically for activity in the rat passive cutaneous anaphylaxis test
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 111(5)
In this study, we attempted to confirm the assessment system of incidence of angialgia and thrombophlebitis by evaluating the influence of test solutions on the vascular permeability by intradermal injection into rat skin, and following results were