Výsledky vyhledávání - "Isami Fujita"

Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac

Autor: Ayano Sakakibara, Yasuhiro Kita, Isami Fujita, Takako Okumura

Publikováno v: The Journal of pharmacy and pharmacology. 64(5)

Objectives Post-operative pain is considered to involve inflammation caused by tissue injury. However, the mechanism and timing of the involvement of inflammation in the post-operative pain remain complicated because they can vary among different typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be92ee7d928f0cf137d60592b8cecb5c
https://pubmed.ncbi.nlm.nih.gov/22471372

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Anti-PDGF-B monoclonal antibody reduces liver fibrosis development

Autor: Shinji, Ogawa, Takashi, Ochi, Hideaki, Shimada, Kazuyuki, Inagaki, Isami, Fujita, Aisuke, Nii, Mark A, Moffat, Madan, Katragadda, Bernard N, Violand, Robert H, Arch, Jaime L, Masferrer

Publikováno v: Hepatology research : the official journal of the Japan Society of Hepatology. 40(11)

To evaluate the usefulness of a platelet-derived growth factor (PDGF)-B specific monoclonal antibody (mAb) as a therapeutic agent to treat chronic liver fibrosis. Liver fibrosis was induced in ICR mice by bile duct ligation (BDL) or BALB/c mice by we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69ee81affa74536a341cf702960d570d
https://pubmed.ncbi.nlm.nih.gov/20880061

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Gene expression changes in dorsal root ganglion of rat experimental lumber disc herniation models

Autor: Hideaki Shimada, Miho Sekiguchi, Shinichi Kikuchi, Shoji Yabuki, Bunji Takayama, Isami Fujita

Publikováno v: Spine. 33(17)

Study Design. Comprehensive overviews of gene expression changes in dorsal root ganglion (DRG) were obtained using microarrays in 2 rat models of experimental lumbar disc herniation (LDH). Objective. To clarify the mechanisms of painful radiculopathy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6992ad4366e1ef0ebb424a82c8fe97ad
https://pubmed.ncbi.nlm.nih.gov/18670335

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Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain

Autor: Shuzo Watanabe, Isao Sakurada, Makoto Kawai, Masanori Hizue, Mitsuhiro Kawamura, Kazunari Hattori, Tadashi Takashima, Hiroshi Nakamura, Ando Kazuo, Atsuko Ohta, Mizutani Mayumi, Hirota Masako, Isami Fujita, Yukari Matsumoto, Masaki Sudo

Publikováno v: Bioorganicmedicinal chemistry letters. 17(20)

(-)-6-[2-[4-(3-Fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone was identified as an orally active NR2B-subunit selective N-methyl-d-aspartate (NMDA) receptor antagonist. It has very high selectivity for NR2B subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d56115c2d64610f4fdf1544988496a
https://pubmed.ncbi.nlm.nih.gov/17766106

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Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes

Autor: Norio Itoh, Junko Hirano, Ximei Wu, Takuma Iguchi, Tsuyoshi Nakanishi, Isami Fujita, Hidenori Ueda, Keiichi Tanaka

Publikováno v: Biochemical pharmacology. 74(7)

The hyperglycemia and hyperoxidation that characterize diabetes lead to reduced vitamin C (L-ascorbic acid, AA) levels in diabetic humans and animals. We examined the possibility that diabetes-induced low plasma AA levels impair AA distribution to va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdeff62f6a2d7d74fcc060769d9f585
https://pubmed.ncbi.nlm.nih.gov/17689499

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Pharmacological separation between peripheral and central functions of cyclooxygenase-2 with CIAA, a novel cyclooxygenase-2 inhibitor

Autor: Rie Naganeo, Yoshihito Kanai, Akio Murase, Takako Okumura, Tomomi Matsuura, Ayano Sakakibara, Masanori Hizue, Kazunari Nakao, Yoko Murata, Isami Fujita

Publikováno v: European journal of pharmacology. 539(1-2)

There are many reports concerning the physiological and pathological involvement of cyclooxygenase (COX)-2 in the central nervous system and peripheral tissue cells. Selective COX-2 inhibitors that mainly distribute peripherally have not been reporte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d760513337f2def0c15ed006575907e2
https://pubmed.ncbi.nlm.nih.gov/16690052

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Dexamethasone induces sodium-dependant vitamin C transporter in a mouse osteoblastic cell line MC3T3-E1

Autor: Junko Hirano, Keiichi Tanaka, T. Nakanishi, N. Itoh, Isami Fujita

Publikováno v: The British journal of nutrition. 86(2)

The regulation of intracellular ascorbic acid (AsA) levels may be under the control of an AsAspecific membrane transporter. The present study investigates AsA uptake and expression of Nadependent vitamin C transporter (SVCT) mRNA in the mouse osteobl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba1e153a12051fbd3b80b44098f6867
https://pubmed.ncbi.nlm.nih.gov/11502226

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Tissue accumulation of cadmium following oral administration to metallothionein-null mice

Autor: Norio Itoh, Tomoki Kimura, Isami Fujita, Keiichi Tanaka, Norio Muto, Kyong-Son Min

Publikováno v: Toxicology letters. 99(2)

To verify the roles of intestinal metallothionein (MT) as a barrier against ingested cadmium (Cd) and as a transporter of mucosal Cd to the kidneys, the distribution of orally administered Cd was compared between normal and MT-I and -II knock-out (MT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e2cdc33c6e08470c7f78a1c45dc669
https://pubmed.ncbi.nlm.nih.gov/9817079

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