Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Isam Qahwash"'
Autor:
John R White, Sammina Ahmed, Jan Amstrup, Petra Bennington, Zhijie Jey Cheng, Peter Day, Keneshia K Haenssen, Adi Kozminsky-Atias, Eva Martinez, Esther HQ Ong, Isam Qahwash, Elaine SE Stokes, Jenny Wang
Publikováno v:
BioTechniques, Vol 76, Iss 4, Pp 135-144 (2024)
The BioPhorum Development Group is an industry collaboration enabling the sharing of common practices for the development of biopharmaceuticals. Bioassays are an important part of an analytical control system. Utilization of ready-to-use cells can in
Externí odkaz:
https://doaj.org/article/906e6b3860584bce95f046732311ad20
Autor:
John R White, Marla Abodeely, Sammina Ahmed, Gaël Debauve, Evan Johnson, Debra M Meyer, Ned M Mozier, Matthias Naumer, Alessandra Pepe, Isam Qahwash, Edward Rocnik, Jeffrey G Smith, Elaine SE Stokes, Jeffrey J Talbot, Pin Yee Wong
Publikováno v:
BioTechniques, Vol 67, Iss 3, Pp 126-137 (2019)
Biological activity is a critical quality attribute for biopharmaceuticals, which is accurately measured using an appropriate relative potency bioassay. Developing a bioassay is a complex, rigorous undertaking that needs to address several challenges
Externí odkaz:
https://doaj.org/article/a956d410bab14152a653a980043013fe
Autor:
Ned M. Mozier, Gaël Debauve, Evan Johnson, Alessandra Pepe, Marla Abodeely, Matthias Naumer, Jeffrey J Talbot, Sammina Ahmed, Edward Rocnik, John R. White, Elaine Se Stokes, Pin Yee Wong, Isam Qahwash, Debra M. Meyer, Jeffrey G. Smith
Publikováno v:
BioTechniques. 67:126-137
Biological activity is a critical quality attribute for biopharmaceuticals, which is accurately measured using an appropriate relative potency bioassay. Developing a bioassay is a complex, rigorous undertaking that needs to address several challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1834b7c3227259667d10c34ef99ffc1
https://doi.org/10.2144/btn-2019-0031
https://doi.org/10.2144/btn-2019-0031
Publikováno v:
Nature Medicine. 10:959-965
Inhibiting the activity of the beta-amyloid converting enzyme 1 (BACE1) or reducing levels of BACE1 in vivo decreases the production of amyloid-beta. The reticulon family of proteins has four members, RTN1, RTN2, RTN3 and RTN4 (also known as Nogo), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db41ae66ef6ac34f5501ba74e6188d2
https://doi.org/10.1038/nm1088
https://doi.org/10.1038/nm1088
Autor:
June M. Lull, Carol A. Bannow, Riqiang Yan, Alfredo G. Tomasselli, Thomas L. Emmons, Isam Qahwash, Michael Jerome Bienkowski, Kam F. Fok, Clark W. Smith, Joseph W. Leone, Yifeng Lu, Robert L. Heinrikson
Publikováno v:
Journal of Neurochemistry. 84:1006-1017
The involvement of β-secretase (BACE1; β-site APP-cleaving enzyme) in producing the β-amyloid component of plaques found in the brains of Alzheimer's patients, has fueled a major research effort to characterize this protease. Here, we describe wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918f105b854f505ed1ea7223d2f1ff7c
https://doi.org/10.1046/j.1471-4159.2003.01597.x
https://doi.org/10.1046/j.1471-4159.2003.01597.x
Publikováno v:
The Journal of biological chemistry. 279(37)
Membrane-bound BACE1 naturally cleaves its transmembrane substrate amyloid precursor protein (APP) at the two adjacent beta- and beta'-sites. Cleavage at these two sites generates the heterogeneous N-terminal end of APP C-terminal fragments that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239195cc17f20e24a7a0b88347e390e0
https://pubmed.ncbi.nlm.nih.gov/15234966
https://pubmed.ncbi.nlm.nih.gov/15234966
Autor:
Isam Qahwash, Katherine L. Weiland, Rolf F. Kletzien, Ronald W. Sarver, Riqiang Yan, Yifeng Lu
Publikováno v:
The Journal of biological chemistry. 278(25)
The amyloid peptide (Abeta), derived from the proteolytic cleavage of the amyloid precursor protein (APP) by beta- and gamma-secretases, undergoes multistage assemblies to fibrillar depositions in the Alzheimer's brains. Abeta protofibrils were previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d3d7b1638cd47447c2dd32bc869b65
https://pubmed.ncbi.nlm.nih.gov/12684519
https://pubmed.ncbi.nlm.nih.gov/12684519
Autor:
Alfredo G, Tomasselli, Isam, Qahwash, Thomas L, Emmons, Yifeng, Lu, Joseph W, Leone, June M, Lull, Kam F, Fok, Carol A, Bannow, Clark W, Smith, Michael J, Bienkowski, Robert L, Heinrikson, Riqiang, Yan
Publikováno v:
Journal of neurochemistry. 84(5)
The involvement of beta-secretase (BACE1; beta-site APP-cleaving enzyme) in producing the beta-amyloid component of plaques found in the brains of Alzheimer's patients, has fueled a major research effort to characterize this protease. Here, we descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b13dcf7e0acf3ba2cce4cd0921b08f7
https://pubmed.ncbi.nlm.nih.gov/12603825
https://pubmed.ncbi.nlm.nih.gov/12603825