Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Isam Elamri"'
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Akademický článek
Short-chain aurachin D derivatives are selective inhibitors of E. coli cytochrome bd-I and bd-II oxidases
Autor: Melanie Radloff, Isam Elamri, Tamara N. Grund, Luca F. Witte, Katharina F. Hohmann, Sayaka Nakagaki, Hojjat G. Goojani, Hamid Nasiri, Hideto Miyoshi, Dirk Bald, Hao Xie, Junshi Sakamoto, Harald Schwalbe, Schara Safarian
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Cytochrome bd-type oxidases play a crucial role for survival of pathogenic bacteria during infection and proliferation. This role and the fact that there are no homologues in the mitochondrial respiratory chain qualify cytochrome bd as a pot
Externí odkaz: https://doaj.org/article/93a47c381cd747e793e88d2862b66fb8
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2
Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli
Autor: Tamara N. Grund, Melanie Radloff, Di Wu, Hojjat G. Goojani, Luca F. Witte, Wiebke Jösting, Sabine Buschmann, Hannelore Müller, Isam Elamri, Sonja Welsch, Harald Schwalbe, Hartmut Michel, Dirk Bald, Schara Safarian
Publikováno v: Proc Natl Acad Sci U S A
Grund, T N, Radloff, M, Wu, D, Goojani, H G, Witte, L F, Jösting, W, Buschmann, S, Müller, H, Elamri, I, Welsch, S, Schwalbe, H, Michel, H, Bald, D & Safarian, S 2021, ' Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 50, e2114013118, pp. 1-11 . https://doi.org/10.1073/pnas.2114013118
Proceedings of the National Academy of Sciences of the United States of America, 118(50):e2114013118, 1-11. National Acad Sciences
The treatment of infectious diseases caused by multidrug-resistant pathogens is a major clinical challenge of the 21st century. The membrane-embedded respiratory cytochrome bd-type oxygen reductase is a critical survival factor utilized by pathogenic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0de252d5310ee8dcb6dcd02ad792aac
https://research.vu.nl/en/publications/d0f38fc9-8303-4667-aa17-1eaaba36046b
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3
Wavelength-Selective Uncaging of Two Different Photoresponsive Groups on One Effector Molecule for Light-Controlled Activation and Deactivation
Autor: Elke Stirnal, Harald Schwalbe, Isam Elamri, Santosh Lakshmi Gande, Chahinez Abdellaoui, Jasleen Kaur Bains, Katharina F. Hohmann, Josef Wachtveitl
Publikováno v: Journal of the American Chemical Society. 143:10596-10603
Photocleavable protecting groups (PPGs) play a pivotal role in numerous studies. They enable controlled release of small effector molecules to induce biochemical function. The number of PPGs attached to a variety of effector molecules has grown rapid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cae3a34983d03b4c49e00f68389dc5
https://doi.org/10.1021/jacs.1c02817
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5
Synthesis and biological screening of new Lawson derivatives as selective substrate‐based inhibitors of cytochrome bo3 ubiquinol oxidase from escherichia coli
Autor: Michael Bolte, Vijaykumar D. Nimbarte, Melanie Radloff, Hartmut Michel, Hamid R. Nasiri, Harald Schwalbe, Katharina F. Hohmann, Isam Elamri, Schara Safarian
Publikováno v: Chemmedchem
The respiratory chain of Escherichia coli contains two different types of terminal oxidase that are differentially regulated as a response to changing environmental conditions. These oxidoreductases catalyze the reduction of molecular oxygen to water
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93889b8d23f17437774112f862e30f8f
http://publikationen.ub.uni-frankfurt.de/files/56501/container.zip
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6
Light-induced antibiotic release from a coumarin-caged compound on the ultrafast timescale
Autor: L-M Herzig, Isam Elamri, Harald Schwalbe, Josef Wachtveitl
Publikováno v: Physical Chemistry Chemical Physics. 19:14835-14844
A synthesis route for puromycin caged with the photo-responsive 7-diethylaminocoumarinyl protecting group carbamate was developed. The inactivation and recovery of the cytotoxic effect of puromycin was tested with a XTT cell viability assay. The unca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb5ae70ade29d519af9a277caa1b578
https://doi.org/10.1039/c7cp02030a
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8
A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons
Autor: Elke Stirnal, Isam Elamri, Harald Schwalbe, Lisa-M. Herzig, Erin M. Schuman, Josef Wachtveitl, Maximilian Heumüller
Publikováno v: ChemBioChem: A European Journal of Chemical Biology
Monitoring newly synthesized proteins is becoming increasingly important to characterize proteome composition in regulatory networks. Puromycin is a peptidyl transfer inhibitor, widely used in cell biology for tagging newly synthesized proteins. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0114954b7e7180c2bf11161eaf9207
https://pubmed.ncbi.nlm.nih.gov/30311996
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9
Photodynamics of Coumarin Caged Puromycin: Release of an Antibiotic on the Ultrafast Timescale
Autor: Josef Wachtveitl, Harald Schwalbe, Isam Elamri, Lisa-M. Herzig
Publikováno v: International Conference on Ultrafast Phenomena.
Photocleavage of caged puromycin is a promising method for the controlled release of an antibiotic. We introduce a new type of caged puromycin with favorable photodynamic properties for in-cell applications.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffdb291fabf7aced73c7d73d9a75ef06
https://doi.org/10.1364/up.2016.utu4a.12
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