Zobrazeno 1 - 10
of 504
pro vyhledávání: '"Isaiah J. Fidler"'
Autor:
Sun-Jin Kim, Jang-Seong Kim, Eun Sung Park, Ju-Seog Lee, Qingtang Lin, Robert R. Langley, Marva Maya, Junqin He, Seung-Wook Kim, Zhang Weihua, Krishnakumar Balasubramanian, Dominic Fan, Gordon B. Mills, Mien-Chie Hung, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 3, Pp 286-298 (2011)
In the United States, more than 40% of cancer patients develop brain metastasis. The median survival for untreated patients is 1 to 2 months, which may be extended to 6 months with conventional radiotherapy and chemotherapy. The growth and survival o
Externí odkaz:
https://doaj.org/article/298f851c3462484aa6d1fece1afde524
Autor:
Sun-Jin Kim, Jang Seong Kim, Seung Wook Kim, Emily Brantley, Seok Joong Yun, Junqin He, Marva Maya, Fahao Zhang, Qiuyu Wu, François Lehembre, Urs Regenass, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 2, Pp 167-179 (2011)
Potential treatments for ovarian cancers that have become resistant to standard chemotherapies include modulators of tumor cell survival, such as endothelin receptor (ETR) antagonist. We investigated the therapeutic efficacy of the dual ETR antagonis
Externí odkaz:
https://doaj.org/article/7ccd198f6b6b45db91c654b062b68a9e
Autor:
Qingtang Lin, Krishnakumar Balasubramanian, Dominic Fan, Sun-Jin Kim, Lixia Guo, Hua Wang, Menashe Bar-Eli, Kenneth D. Aldape, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 9, Pp 748-754 (2010)
Brain metastases are highly resistant to chemotherapy. Metastatic tumor cells are known to exploit the host microenvironment for their growth and survival. We report here that melanoma brain metastases are surrounded and infiltrated by activated astr
Externí odkaz:
https://doaj.org/article/3983dfad37874a64b14cde2803962811
Autor:
Robert B. Rebhun, Hua Cheng, Jeffrey E. Gershenwald, Dominic Fan, Isaiah J. Fidler, Robert R. Langley
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 2, Pp 173-182 (2010)
The lymphatic system plays a critical role in melanoma metastasis, and yet, virtually no information exists regarding the cellular and molecular mechanisms that take place between melanoma cells and the lymphatic vasculature. Here, we generated B16-F
Externí odkaz:
https://doaj.org/article/8b4ba89d5ed74c50958db3bbb6668afb
Autor:
Toshio Kuwai, Toru Nakamura, Takamitsu Sasaki, Sun-Jin Kim, Dominic Fan, Gabriel J. Villares, Maya Zigler, Hua Wang, Menashe Bar-Eli, Robert S. Kerbel, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 5, Pp 489-500 (2008)
We determined whether phosphorylated epidermal growth factor receptor (EGFR) expressed on tumor-associated endothelial cells is a primary target for therapy with EGFR tyrosine kinase inhibitors (TKIs). Human colon cancer cells SW620CE2 (parental) tha
Externí odkaz:
https://doaj.org/article/62bc31d4a0c84f63b5e9a9bab47fa4c8
Autor:
Takamitsu Sasaki, Yasuhiko Kitadai, Toru Nakamura, Jang-Seong Kim, Rachel Z. Tsan, Toshio Kuwai, Robert R. Langley, Dominic Fan, Sun-Jin Kim, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 12, Pp 1066-1077 (2007)
The purpose of our study was to determine whether the dual inhibition of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) signaling pathways in tumor-associated endothelial cells can inhibit the progress
Externí odkaz:
https://doaj.org/article/313bbe7319b944be972e14f542a88038
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 11, Pp 979-986 (2007)
We determined whether host matrix metalloproteinase (MMP) 9 is essential to angiogenesis and to the growth of L3.6pl human pancreatic cancer cells implanted into the pancreas of wild-type (MMP−9+/+) and knockout (MMP−9−/−) nude mice. Four wee
Externí odkaz:
https://doaj.org/article/3ed9bcd5beda4f56b712ce5c422a1caa
Autor:
Robert B. Rebhun, Robert R. Langley, Kenji Yokoi, Dominic Fan, Jeffrey E. Gershenwald, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 9, Pp 747-757 (2006)
Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum. Wh
Externí odkaz:
https://doaj.org/article/be339321da364dc19989377329bf6008
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 7, Pp 543-550 (2006)
Direct injection of murine K-1735 melanoma cells into the subcutis, lung, or brain of syngeneic mice produces amelanotic tumors, whereas intravenous injection into the lateral tail vein or internal carotid artery produces both amelanotic and melanoti
Externí odkaz:
https://doaj.org/article/d2580bbe987c4dbebba8b354fa5355af
Autor:
Hua Cheng, Robert R. Langley, Qiuyu Wu, Wenjuan Wu, Jie Feng, Rachel Tsan, Dominic Fan, Isaiah J. Fidler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 12, Pp 1065-1072 (2005)
Tumor cells and tumor-associated endothelial cells express activated epidermal growth factor receptor (EGFR) due to production of EGF-related ligands in the tumor microenvironment. To investigate the effect of perpetual EGFR activation on endothelial
Externí odkaz:
https://doaj.org/article/b137cd0fbdf14fae8d0cc5bd3e9003e5