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pro vyhledávání: '"Isadore A. Bernstein"'
Regulation in epidermal differentiation can best be studied if molecular mechanisms can be associated with structural and functional changes. Such recognized associations include the cessation of mitosis through inhibition of DNA replication by a G1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eddfa8dbec4f727318ce19d08e8ff572
https://doi.org/10.1159/000396305
https://doi.org/10.1159/000396305
Autor:
Isadore A. Bernstein, James D. Zieske
SummaryThe specific binding of lectins to the cell surfaces in particular epidermal strata indicates that oligosaccharide moieties of the glycoconjugates on the cell membrane are altered as the keratinocyte differentiates. The disappearance of bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02c3aa25fc6133cd927099d71b1ecaa
https://doi.org/10.1159/000408679
https://doi.org/10.1159/000408679
Publikováno v:
Toxicology Letters. 84:23-32
Epidermal basal keratinocytes are the primary target in BCES-induced cutaneous injury. DNA synthesis is inhibited by exposure to BCES which could relate to the mustard's cytotoxic effect. The effects of BCES on the cell cycle in keratinocytes synchro
Autor:
Jianming Xiang, Isadore A. Bernstein
Publikováno v:
Biochemical and Biophysical Research Communications. 189:27-32
An enzymatic activity catalyzing the transfer of L-fucose from GDP-L-fucose to a glycoprotein that is associated with the surfaces of the basal cells has been found in the membranous fraction of the cutaneous epidermis from the newborn rat. This fuco
Publikováno v:
Chemico-Biological Interactions. 84:133-142
A primary stratified keratinocyte culture resembling the epidermis in situ was used as a model for studying the effects of exposure to 2,2'-dichlorodiethyl sulfide, or sulfur mustard (SM), on DNA synthesis. A method that distinguishes between semi-co
Publikováno v:
Toxicology and Applied Pharmacology. 111:342-351
Toxicity manifests itself as vesication in human skin exposed topically to bis(2-chloroethyl)sulfide (BCES). The destruction of the proliferating population of epidermal cells is a major component of the pathogenic process. Available data strongly su
Autor:
Liju Fan, Isadore A. Bernstein
Publikováno v:
Toxicology and Applied Pharmacology. 111:233-241
Sulfur mustard, bis(beta-chloroethyl)sulfide (BCES), a bifunctional alkylating agent, is a vesicant whose mode of action involves interference with the integrity of cellular DNA. Alkylation of DNA is responsible for some of the biological effects of
Publikováno v:
Journal of Dermatological Science. 1:173-181
It was previously reported that rat keratinocytes grown at the air-liquid interface on collagen gels or on nylon membranes produce multilayered cultures of uniformly stratified cells, comparable to the epidermis in situ by morphological and biochemic
Publikováno v:
Journal of Investigative Dermatology. 94(1):86-93
Induction of microsomal aryl hydrocarbon hydroxylase and cytochrome P-450 was observed in epidermal cells obtained from the skin of newborn rats exposed to benz(a)anthracene by topical exposure and in submerged cultures exposed to the procarcinogen i
Publikováno v:
ResearcherID
Interstrand cross-links in the DNA of epidermal basal keratinocytes may be responsible for cell death and consequent vesication in skin exposed to BCES. The formation of cross-links and cytotoxicity were compared when cells in primary monolayer cultu