Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies

Autor: Isabel M de Andrade, Guilherme A. M. Jardim, Isadora M.M. de Melo, Eufrânio N. da Silva Júnior, Antoniana U. Krettli, Paula F. Carneiro, Nicolli B de Souza

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 109, Iss 5, Pp 546-552 (2014)
Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz, Volume: 109, Issue: 5, Pages: 546-552, Published: 05 AUG 2014

Due to the recent advances of atovaquone, a naphthoquinone, through clinical trials as treatment for malarial infection, 19 quinone derivatives with previously reported structures were also evaluated for blood schizonticide activity against the malar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e4c18b95bbb2179b244e07e16d038c
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500546&lng=en&tlng=en

On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by clik chemistry reactions

Autor: Isadora M.M. de Melo, Wagner O. Valença, Emilay B. T. Diogo, Ronaldo N. de Oliveira, Alexandre Suman de Araujo, Carlos A. de Simone, Flavio da Silva Emery, Rubem F. S. Menna-Barreto, José Dias de Souza Filho, Solange L. de Castro, Verenice A. Costa, Eufrânio N. da Silva Júnior, Marcelo Rodrigues dos Santos, Celso A. Camara

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones, five nor-β-lapachone-based 1,2,3-triazoles, and several other naphthoquinonoid compounds were synthesized and evaluated against the infective bloods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8c5b1e45513c9d6991bb3bee774b29