Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Isacchini, Giulio"'
Autor:
Isacchini, Giulio, Quiniou, Valentin, Vantomme, Hélène, Stys, Paul, Mariotti-Ferandiz, Encarnita, Klatzmann, David, Walczak, Aleksandra M., Mora, Thierry, Nourmohammad, Armita
The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acquired and selected during T cell maturation in the thymus. Characteriz
Externí odkaz:
http://arxiv.org/abs/2307.14376
Autor:
Isacchini, Giulio, Spisak, Natanael, Nourmohammad, Armita, Mora, Thierry, Walczak, Aleksandra M.
Simulation-based inference enables learning the parameters of a model even when its likelihood cannot be computed in practice. One class of methods uses data simulated with different parameters to infer models of the likelihood-to-evidence ratio, or
Externí odkaz:
http://arxiv.org/abs/2106.01808
Subclasses of lymphocytes carry different functional roles to work together to produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains to recogni
Externí odkaz:
http://arxiv.org/abs/2011.03112
Autor:
Montague, Zachary, Lv, Huibin, Otwinowski, Jakub, DeWitt, William S., Isacchini, Giulio, Yip, Garrick K., Ng, Wilson W., Tsang, Owen Tak-Yin, Yuan, Meng, Liu, Hejun, Wilson, Ian A., Peiris, J. S. Malik, Wu, Nicholas C., Nourmohammad, Armita, Mok, Chris Ka Pun
COVID-19 patients show varying severity of the disease ranging from asymptomatic to requiring intensive care. Although a number of SARS-CoV-2 specific monoclonal antibodies have been identified, we still lack an understanding of the overall landscape
Externí odkaz:
http://arxiv.org/abs/2007.06762
Generalized linear models are one of the most efficient paradigms for predicting the correlated stochastic activity of neuronal networks in response to external stimuli, with applications in many brain areas. However, when dealing with complex stimul
Externí odkaz:
http://arxiv.org/abs/2006.06497
Autor:
Isacchini, Giulio, Olivares, Carlos, Nourmohammad, Armita, Walczak, Aleksandra M., Mora, Thierry
Publikováno v:
Bioinformatics, Volume 36, Issue 16, 15 August 2020, Pages 4510--4512
Recent advances in modelling VDJ recombination and subsequent selection of T and B cell receptors provide useful tools to analyze and compare immune repertoires across time, individuals, and tissues. A suite of tools--IGoR [1], OLGA [2] and SONIA [3]
Externí odkaz:
http://arxiv.org/abs/2003.13149
Autor:
Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra M., Elhanati, Yuval
Publikováno v:
PLoS Computational Biology 16(12) e1008394 (2020)
The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented on the ma
Externí odkaz:
http://arxiv.org/abs/2001.02843
Autor:
Isacchini, Giulio, Sethna, Zachary, Elhanati, Yuval, Nourmohammad, Armita, Walczak, Aleksandra M., Mora, Thierry
Publikováno v:
Phys. Rev. E 101, 062414 (2020)
T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and malignancies. Modeling the distribution of TCR sequences is of key importa
Externí odkaz:
http://arxiv.org/abs/1911.12279
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2021 Apr 01. 118(14), 1-10.
Externí odkaz:
https://www.jstor.org/stable/27039658
Autor:
Moosavi, Vahid, Isacchini, Giulio
The initial theoretical connections between Leontief input-output models and Markov chains were established back in 1950s. However, considering the wide variety of mathematical properties of Markov chains, there has not been a full investigation of e
Externí odkaz:
http://arxiv.org/abs/1612.06186