Microcalorimeter fabrication and new measurement methodology for thermal sensing in microfluidics

Autor: Martina Freisa, Thi Hong Nhung Dinh, David Bouville, Laurent Couraud, Isabelle Le Potier, Jean Gamby

Publikováno v: Micro and Nano Engineering, Vol 20, Iss , Pp 100222- (2023)

This work describes the integration of a Resistance Thermal Detector (RTD) microcalorimeter integrated into a 324 nL microfluidic channel. The sensor is fabricated in a clean room using photolithography and evaporation techniques, and it has a platin

Externí odkaz: https://doaj.org/article/e0e64a7bdbd14070a3b087e4b9ea03bf

Electropreconcentration diagrams to optimize molecular enrichment with low counter pressure in a nanofluidic device

Autor: Sokhna-Mery Ngom, Fatima Flores‐galicia, Isabelle Le Potier, Jean Gamby, François-Damien Delapierre, Anne-Marie Haghiri-Gosnet, Antoine Pallandre

Publikováno v: Electrophoresis
Electrophoresis, Wiley-VCH Verlag, 2020, 41 (18-19), pp.1617-1626. ⟨10.1002/elps.202000117⟩

Concentration polarization (CP)-based focusing electrokinetics nanofluidic devices have been developed in order to simultaneously detect and enrich highly diluted analytes on-a-chip. However, stabilization of focal points over long time under the app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74901020548b28a6e7f10bfcaeebebc1
https://pubmed.ncbi.nlm.nih.gov/32557702

On-a-chip tryptic digestion of transthyretin: a step toward an integrated microfluidic system for the follow-up of familial transthyretin amyloidosis

Autor: jeanne bataille, Antoine Pallandre, Jörg Peter Kutter, Arthur Viode, Stéphanie Descroix, Josiane P. Lafleur, François Becher, Isabelle Le Potier, Fanny Varenne, Myriam Taverna, Christian Poüs, Iago Pereiro, camille roesch, Claire Smadja

Publikováno v: Analyst
Analyst, Royal Society of Chemistry, 2018, 143 (5), pp.1077-1086. ⟨10.1039/c7an01737e⟩

International audience; A microfluidic microreactor for trypsin mediated transthyretin (TTR) digestion has been developed as a step towards the elaboration of a fully integrated microdevice for the detection of a rare and disabling disease, the famil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5559964dbb29c3d394573545fce056
https://hal.inrae.fr/hal-02628957

Derivatization strategies for CE-LIF analysis of biomarkers: Toward a clinical diagnostic of familial transthyretin amyloidosis

Autor: Régis Daniel, Sonia Korchane, Florence Gonnet, Antoine Pallandre, Myriam Taverna, Cédric Przybylski, Isabelle Le Potier, Christian Poüs

Publikováno v: Electrophoresis
Electrophoresis, 2014, 35 (7), pp.1050-1059. ⟨10.1002/elps.201300426⟩
Electrophoresis, Wiley-VCH Verlag, 2014, 35 (7), pp.1050-1059. ⟨10.1002/elps.201300426⟩

International audience; We report three derivatization strategies for CE analysis with LIF detection (CE‐LIF) of two synthetic peptides mimicking the wild and mutated fragments of interest for the diagnosis of familial transthyretin amyloidosis. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b458c048a781ce1adeca4c4d54d6b0d7
https://doi.org/10.1002/elps.201300426

Investigating of labelling and detection of transthyretin synthetic peptide derivatized with naphthalene-2,3-dicarboxaldehyde

Autor: Isabelle Le Potier, Antoine Pallandre, Anne-Marie Haghiri-Gosnet, Jean Gamby, Claude Deslouis, Mathilde Faure, Sonia Korchane

Publikováno v: Talanta
Talanta, Elsevier, 2013, 116, pp.8-13. ⟨10.1016/j.talanta.2013.04.060⟩
Talanta, 2013, 116, pp.8-13. ⟨10.1016/j.talanta.2013.04.060⟩

International audience; Labelling and detection of a synthetic peptide (PN) mimicking a tryptic fragment of interest for the diagnosis of familial amyloidal polyneuropathy have been investigated optically and electrochemically. We decided to covalent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7bcf6f2d7187640925f69d03cc745e
https://doi.org/10.1016/j.talanta.2013.04.060