Výsledky vyhledávání - "Isabelle Van den Eynde"

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20

Autor: Engin Bojnik, Sándor Benyhe, Steven Ballet, Dirk Tourwé, Piotr Kosson, Lipkowski Andrzej W, Isabelle Van den Eynde, Patrycja Kleczkowska, Anna Leśniak

Publikováno v: Pharmacological Reports. 65:836-846

Background Recently, we presented a novel compound (PK20, Dmt-D-Lys-Phe-Phe-Lys-Lys-Pro-Phe-Tle-Leu-OH) that targets single entity opioid and neurotensin pharmacophores. This endomorphin-2-like opioid peptide was introduced as a highly active analges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e4be7a0dc001dc68f35d44c03e34ba
https://doi.org/10.1016/s1734-1140(13)71064-8

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Conformational constraints in angiotensin IV to probe the role of Tyr2, Pro5 and Phe6

Autor: Isabelle Van den Eynde, Patrick Vanderheyden, Georges Vauquelin, Heidi Demaegdt, Aneta Lukaszuk, Dirk Tourwé

Publikováno v: Journal of Peptide Science. 17:545-553

The aromatic amino acids Tyr and Phe in angiotensin IV (Ang IV) were conformationally constrained by the use of β-Me substituted analogs, or cyclic constrained analogs. None of these modifications was allowed for Tyr¹, while only e-β-MePhe⁶ subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5e657fdb57bcad7b74f9c3142f9d8dc
https://doi.org/10.1002/psc.1365

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Influence of ring substitution on the conformation and β-turn mimicry of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one peptide mimetics

Autor: Zofia Urbańczyk-Lipkowska, Rien De Wachter, Debby Feytens, Isabelle Van den Eynde, Steven Ballet, Attila Keresztes, Géza Tóth, Dirk Tourwé, Luc Brans

Publikováno v: Tetrahedron. 65:2266-2278

Analogs of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-ones, containing a methyl substituent at the 4- or 5-position, or a phenyl substituent at C-1, were prepared. Conformational analysis of tetrapeptide models containing these analogs indicated diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea8f9428c0c27c743eed1c794b2a3d49
https://doi.org/10.1016/j.tet.2009.01.057

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Synthesis of 4-amino-3-oxo-tetrahydroazepino[3,4-b]indoles: new conformationally constrained Trp analogs

Autor: Debby Feytens, Dirk Tourwé, Nga N. Chung, Aleksandra Misicka, Karolina Pulka, Andrzej W. Lipkowski, Rien De Wachter, Piotr Kosson, Isabelle Van den Eynde, Peter W. Schiller

Publikováno v: Tetrahedron. 63:1459-1466

The synthesis of tryptophan analogs is reported in which the conformation has been constrained by formation of a seven-membered lactam. Boc-protected 2′-formyl tryptophan was obtained by SeO2 oxidation of Boc-tetrahydro-β-carboline-3-carboxylic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::584ff2df4821429e45e0196321acf1ca
https://doi.org/10.1016/j.tet.2006.11.069

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Solid-Supported Solution-Phase Synthesis of 4-Amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones

Autor: Dirk Tourwé, Karolien Van Rompaey, and Francesco Lazzaro, Isabelle Van den Eynde

Publikováno v: Journal of Combinatorial Chemistry. 6:468-473

Starting from Boc-o-aminomethylphenylalanine, a solution-phase parallel synthesis of 2,4-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones is described. This heterocycle has two nitrogen functions, which are differentiated and can be select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd7d0c964da9e884f93d383fc425504
https://doi.org/10.1021/cc049940w

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[3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase

Autor: Georges Vauquelin, Alexandros Nikolaou, Jayapal Reddy Mallareddy, Marko Poglitsch, Patrick Vanderheyden, Géza Tóth, Isabelle Van den Eynde, D. Tourwe, Jo A. Van Ginderachter

The hexapeptide angiotensin IV (Ang IV) induces diverse biological effects such as memory enhancement and protection against ischemic stroke. Studies on the mechanism of Ang IV however are hampered by its instability and its lack of selectivity. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86a6dbd62d4b4c9001bbf7afa366069
https://hdl.handle.net/20.500.14017/cadb34dc-9a19-4eca-a749-4fdec40f1f1b

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In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera

Autor: Dirk Tourwé, Patrycja Kleczkowska, Muhammad Faheem Asim, Steven Ballet, Andrzej W. Lipkowski, Bart Vandormael, Karel Guillemyn, Isabelle Van den Eynde, Mariana Spetea, Peter W. Schiller, Piotr Kosson, Alexandre Novoa

Publikováno v: Molecular Brain
Molecular Brain, Vol 5, Iss 1, p 4 (2012)

Background An important limiting factor in the development of centrally acting pharmaceuticals is the blood-brain barrier (BBB). Transport of therapeutic peptides through this highly protective physiological barrier remains a challenge for peptide dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0da29826fa04db61f954c13aa3d78bd
https://pubmed.ncbi.nlm.nih.gov/22289619

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