Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Isabelle Tranoy-Opalinski"'
Autor:
Isabelle Tranoy-Opalinski, Nahla Araji, Jérôme Alsarraf, Mikaël Thomas, Brigitte Renoux, Sébastien Papot
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (22), pp.5420-5427. ⟨10.1039/c9ob00789j⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (22), pp.5420-5427. ⟨10.1039/c9ob00789j⟩
International audience; The Lossen rearrangement, that allows the conversion of hydroxamic acids into isocyanates, was discovered almost 150 years ago. For more than a century, this transformation was supposed to occur exclusively in the presence of
Autor:
Arnaud Monvoisin, Sébastien Papot, Brigitte Renoux, Isabelle Tranoy-Opalinski, François Guilhot, Laurent Cronier, Elodie Péraudeau, Jonathan Clarhaut, Pauline Poinot, C. Mergault
Publikováno v:
Journal of Controlled Release
Journal of Controlled Release, 2018, 269, pp.36-44. ⟨10.1016/j.jconrel.2017.11.011⟩
Journal of Controlled Release, Elsevier, 2018, 269, pp.36-44. ⟨10.1016/j.jconrel.2017.11.011⟩
Journal of Controlled Release, 2018, 269, pp.36-44. ⟨10.1016/j.jconrel.2017.11.011⟩
Journal of Controlled Release, Elsevier, 2018, 269, pp.36-44. ⟨10.1016/j.jconrel.2017.11.011⟩
International audience; Several folate-drug conjugates are currently undergoing clinical trials for application in oncology. However, the efficacy of folate-targeted therapy strongly depends on the folate receptor (FR) abundance at the surface of can
Autor:
Pauline Poinot, Elodie Péraudeau, Jérôme Alsarraf, Jonathan Clarhaut, Isabelle Tranoy-Opalinski, Brigitte Renoux, Sébastien Papot
Publikováno v:
Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2015, 51 (87), pp.15792-15795. ⟨10.1039/c5cc05294g⟩
Chemical Communications, Royal Society of Chemistry, 2015, 51 (87), pp.15792-15795. ⟨10.1039/C5CC05294G⟩
Chemical Communications, Royal Society of Chemistry, 2015, 51 (87), pp.15792-15795. ⟨10.1039/c5cc05294g⟩
Chemical Communications, Royal Society of Chemistry, 2015, 51 (87), pp.15792-15795. ⟨10.1039/C5CC05294G⟩
We report the study of a new drug delivery system programmed for the selective internalisation and the subsequent enzyme-catalysed release of two monomethylauristatin E molecules inside FR-positive cancer cells. This targeting device is the most pote
Autor:
Sébastien Papot, Balkis Eddhif, Alain Le Pape, Jérôme Alsarraf, Isabelle Tranoy-Opalinski, Brigitte Renoux, Thibaut Legigan, Pauline Poinot, Florian Raes, Elodie Péraudeau, Stéphanie Lerondel, Jonathan Clarhaut, Sergii Kolodych, Oleksandr Koniev
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2017, 8 (5), pp.3427-3433. ⟨10.1039/C7SC00472A⟩
Chemical Science, The Royal Society of Chemistry, 2017, 8 (5), pp.3427-3433. ⟨10.1039/C7SC00472A⟩
The development of novel therapeutic strategies allowing the destruction of tumour cells while sparing healthy tissues is one of the main challenges of cancer chemotherapy. Here, we report on the design and antitumour activity of a low-molecular-weig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd61bda09672b28f56e60d15bcd742d
https://hal.archives-ouvertes.fr/hal-02174996
https://hal.archives-ouvertes.fr/hal-02174996
Autor:
Brigitte Renoux, Isabelle Tranoy-Opalinski, Romain Barat, Mikaël Thomas, Jonathan Clarhaut, Sébastien Papot, Thibaut Legigan
Publikováno v:
European Journal of Medicinal Chemistry. 74:302-313
The design of novel antitumor agents allowing the destruction of malignant cells while sparing healthy tissues is one of the major challenges in medicinal chemistry. In this context, the use of non-toxic prodrugs programmed to be selectively activate
Autor:
Noël Pairault, Isabelle Tranoy-Opalinski, Sébastien Papot, Mikaël Thomas, Romain Barat, Brigitte Renoux
Publikováno v:
Comptes Rendus. Chimie
Comptes Rendus. Chimie, Académie des sciences (Paris), 2016, 19 (1-2), pp.103-112. ⟨10.1016/j.crci.2015.05.012⟩
Comptes Rendus. Chimie, Académie des sciences (Paris), 2016, 19 (1-2), pp.103-112. ⟨10.1016/j.crci.2015.05.012⟩
International audience; Récemment, le développement de rotaxanes pour des applications biologiques a suscité un intérêt grandissant. Dans cette mise au point, nous résumons les principaux progrès qui ont été réalisés dans ce domaine, en d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcba3c963cf6d890cee98c166b4f1790
https://hal.archives-ouvertes.fr/hal-03127619/document
https://hal.archives-ouvertes.fr/hal-03127619/document
Autor:
Alain Le Pape, Stéphanie Lerondel, Isabelle Tranoy-Opalinski, Sébastien Papot, Jonathan Clarhaut, Thibaut Legigan, Arnaud Monvoisin, Brigitte Renoux, Mikaël Thomas
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51, pp.1-6. ⟨10.1002/anie.201204935⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51, pp.1-6. ⟨10.1002/anie.201204935⟩
International audience; Galactoside prodrugs have been designed that can be selectively activated by lysosomal β-galactosidase located inside cancer cells expressing a specific tumor-associated receptor. This efficient enzymatic process triggers a p
Autor:
Pierre-Olivier Strale, Jonathan Clarhaut, Joëlle Roche, Sébastien Papot, Mickaël Thomas, Isabelle Tranoy-Opalinski
Publikováno v:
ChemMedChem. 6:1006-1010
Autor:
Romain Barat, Isabelle Tranoy-Opalinski, Antony E. Fernandes, Vincent Aucagne, Sébastien Papot, Jonathan Clarhaut, Thibaut Legigan, Pauline Poinot, Elodie Péraudeau, Brigitte Renoux, David A. Leigh
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2015, 6 (4), pp.2608-2613. ⟨10.1039/C5SC00648A⟩
Chemical Science : a new journal for findings of exceptional significance from across the chemical sciences, Vol. 6, no.4, p. 2608-2613 (2015)
Chemical Science, The Royal Society of Chemistry, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩
Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩
Chemical Science, The Royal Society of Chemistry, 2015, 6 (4), pp.2608-2613. ⟨10.1039/C5SC00648A⟩
Chemical Science : a new journal for findings of exceptional significance from across the chemical sciences, Vol. 6, no.4, p. 2608-2613 (2015)
Chemical Science, The Royal Society of Chemistry, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩
Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩
International audience; The development of mechanically interlocked molecular systems programmed to operate autonomously in biological environments is an emerging field of research with potential medicinal applications. Within this framework, functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa935de4107a2000481cc439189aa809
https://hal.archives-ouvertes.fr/hal-01170448
https://hal.archives-ouvertes.fr/hal-01170448
Autor:
Isabelle Tranoy-Opalinski, Brigitte Renoux, Jonathan Clarhaut, Sébastien Papot, Marion Grinda
Publikováno v:
MedChemComm
MedChemComm, Royal Society of Chemistry, 2012, 3 (1), pp.68-70. ⟨10.1039/c1md00193k⟩
MedChemComm, Royal Society of Chemistry, 2012, 3 (1), pp.68-70. ⟨10.1039/c1md00193k⟩
International audience; The first self-immolative dendritic glucuronide prodrug of doxorubicin was studied with the aim to target beta-glucuronidase overexpressed in the microenvironment of numerous tumors. This compound includes a chemical amplifier