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pro vyhledávání: '"Isabelle Thumin"'
Publikováno v:
ChemInform. 33
Autor:
Michel Prévost, Marc Gagnon, Benoit Cardinal-David, Isabelle Thumin, Yvan Guindon, Daniel Chapdelaine
Publikováno v:
ChemInform. 41
D- and L-nucleosides and analogues thereof, including the 4'-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing
Autor:
Yvan Guindon, Daniel Chapdelaine, Michel Prévost, Marc Gagnon, Isabelle Thumin, Benoit Cardinal-David
Publikováno v:
Journal of the American Chemical Society. 131(47)
D- and L-nucleosides and analogues thereof, including the 4'-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing
Publikováno v:
Organic letters. 4(2)
[reaction: see text] Acyclic diastereoselection is achieved for the formation of thioaminyl acetals. The highly intramolecular stereocontrolled S(N)2 displacement of the thioaminyls allows for the formation of cyclic nucleoside derivatives. This vers