Diverged alleles of the Anopheles gambiae leucine-rich repeat gene APL1A display distinct protective profiles against Plasmodium falciparum.

Autor: Inge Holm, Catherine Lavazec, Thierry Garnier, Christian Mitri, Michelle M Riehle, Emmanuel Bischoff, Emma Brito-Fravallo, Eizo Takashima, Isabelle Thiery, Agnes Zettor, Stephane Petres, Catherine Bourgouin, Kenneth D Vernick, Karin Eiglmeier

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52684 (2012)

Functional studies have demonstrated a role for the Anopheles gambiae APL1A gene in resistance against the human malaria parasite, Plasmodium falciparum. Here, we exhaustively characterize the structure of the APL1 locus and show that three structura

Externí odkaz: https://doaj.org/article/d222621ea6b74f9f8f0f00f6f6afe000

Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species.

Autor: Christian Mitri, Jean-Claude Jacques, Isabelle Thiery, Michelle M Riehle, Jiannong Xu, Emmanuel Bischoff, Isabelle Morlais, Sandrine E Nsango, Kenneth D Vernick, Catherine Bourgouin

Publikováno v: PLoS Pathogens, Vol 5, Iss 9, p e1000576 (2009)

Genetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodium falciparum is a common trait in the natural population, and a cluster of natural resistance loci were mapped to the Plasmodium-Resistance Island (PRI) of the A. gambiae g

Externí odkaz: https://doaj.org/article/21edb5a6f83e4d3282051d18d0922876

Immune response of Anopheles gambiae to the early sporogonic stages of the human malaria parasite Plasmodium falciparum

Autor: Catherine Bourgouin, Christian Boudin, Isabelle Thiery, Rachida Tahar

Publikováno v: The EMBO Journal. 21:6673-6680

Deciphering molecular interactions between the malaria parasite and its mosquito vector is an emerging area of research that will be greatly facilitated by the recent sequencing of the genomes of Anopheles gambiae mosquito and of various Plasmodium s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da6769d24bb9cb6560cf20c5efe212
https://doi.org/10.1093/emboj/cdf664

The Introduction into Bacillus sphaericus of the Bacillus thuringiensis subsp. medellin cyt1Ab1 Gene Results in Higher Susceptibility of Resistant Mosquito Larva Populations to B. sphaericus

Autor: Isabelle Thiery, Sylviane Hamon, Sergio Orduz, Armelle Delécluse

Publikováno v: Applied and Environmental Microbiology. 64:3910-3916

The fragment containing the gene encoding the cytolytic Cyt1Ab1 protein from Bacillus thuringiensis subsp. medellin and its flanking sequences (I. Thiery, A. Delécluse, M. C. Tamayo, and S. Orduz, Appl. Environ. Microbiol. 63:468–473, 1997) was i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65569199dba96b2b3eb5130907bc5bca
https://doi.org/10.1128/aem.64.10.3910-3916.1998

Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development

Autor: Anthony A. James, Nijole Jasinskiene, Isabelle Thiery, Agnès Zettor, Catherine Bourgouin, Mikhail Tretiakov, Alison T. Isaacs

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (28), pp.E1922-E1930. ⟨10.1073/pnas.1207738109⟩
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (28), pp.E1922-E1930. ⟨10.1073/pnas.1207738109⟩

Anopheles stephensi mosquitoes expressing m1C3, m4B7, or m2A10 single-chain antibodies (scFvs) have significantly lower levels of infection compared to controls when challenged with Plasmodium falciparum , a human malaria pathogen. These scFvs are de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0547e6f73cb1408beb3d31f4098248a0
https://pubmed.ncbi.nlm.nih.gov/22689959