Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Isabelle St-Amour"'
Autor:
Behnaz Nateghi, Remi Keraudren, Gabriel Boulay, Marc Bazin, Claudia Goupil, Geoffrey Canet, Andréanne Loiselle, Isabelle St-Amour, Emmanuel Planel, Denis Soulet, Sébastien S. Hébert
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Huntington’s disease (HD) is a rare genetic neurodegenerative disorder caused by an expansion of CAG repeats in the Huntingtin (HTT) gene. One hypothesis suggests that the mutant HTT gene contributes to HD neuropathology through transcriptional dys
Externí odkaz:
https://doaj.org/article/4dba236033e24d1196f444a302dfe26c
Autor:
Serena Petry, Rémi Keraudren, Behnaz Nateghi, Andréanne Loiselle, Karolina Pircs, Johan Jakobsson, Chantelle Sephton, Mélanie Langlois, Isabelle St-Amour, Sébastien S. Hébert
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-11 (2022)
Abstract Altered microRNA (miRNA) expression is a common feature of Huntington’s disease (HD) and could participate in disease onset and progression. However, little is known about the underlying causes of miRNA disruption in HD. We and others have
Externí odkaz:
https://doaj.org/article/c663bbb44865472fb1fd41c697fb2267
Autor:
Jérôme Lamontagne-Proulx, Isabelle St-Amour, Richard Labib, Jérémie Pilon, Hélèna L. Denis, Nathalie Cloutier, Florence Roux-Dalvai, Antony T. Vincent, Sarah L. Mason, Caroline Williams-Gray, Anne-Claire Duchez, Arnaud Droit, Steve Lacroix, Nicolas Dupré, Mélanie Langlois, Sylvain Chouinard, Michel Panisset, Roger A. Barker, Eric Boilard, Francesca Cicchetti
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 163-175 (2019)
The production of extracellular vesicles (EV) is a ubiquitous feature of eukaryotic cells but pathological events can affect their formation and constituents. We sought to characterize the nature, profile and protein signature of EV in the plasma of
Externí odkaz:
https://doaj.org/article/8d8cf4f9837744e3b7e12b8b5fafeecf
Autor:
Isabelle St-Amour, Cristina R. Bosoi, Isabelle Paré, Prenitha Mercy Ignatius Arokia Doss, Manu Rangachari, Sébastien S. Hébert, Renée Bazin, Frédéric Calon
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Immunologic abnormalities have been described in peripheral blood and central nervous system of patients suffering from Alzheimer’s disease (AD), yet their role in the pathogenesis still remains poorly defined. Aim and methods W
Externí odkaz:
https://doaj.org/article/e5a34c8ce9f34b57b93c083d2accf88f
Autor:
Emmanuelle Boscher, Julia Hernandez-Rapp, Serena Petry, Remi Keraudren, Sara Rainone, Andréanne Loiselle, Claudia Goupil, Andréanne Turgeon, Isabelle St-Amour, Emmanuel Planel, Sébastien S. Hébert
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
In the past decade, several groups have reported that microRNAs (miRNAs) can participate in the regulation of tau protein at different levels, including its expression, alternative splicing, phosphorylation, and aggregation. These observations are si
Externí odkaz:
https://doaj.org/article/c70e6e7bbe494b8a866c46a3182d5629
Autor:
Karolina Pircs, Rebecca Petri, Sofia Madsen, Per Ludvik Brattås, Romina Vuono, Daniella R. Ottosson, Isabelle St-Amour, Bob A. Hersbach, Monika Matusiak-Brückner, Sofia Hult Lundh, Åsa Petersén, Nicole Déglon, Sébastien S. Hébert, Malin Parmar, Roger A. Barker, Johan Jakobsson
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1397-1406 (2018)
Summary: Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In
Externí odkaz:
https://doaj.org/article/aa4ff126368d4f88950180d6f7fe4264
Autor:
Serena, Petry, Behnaz, Nateghi, Rémi, Keraudren, Nicolas, Sergeant, Emmanuel, Planel, Sébastien S, Hébert, Isabelle, St-Amour
Publikováno v:
Neuroscience. 518:54-63
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expansion of CAG repeats in the Huntingtin (HTT) gene. Accumulating evidence suggests that the microtubule-associated tau protein participates in the pathogenesis of HD
Autor:
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E Jönsson, Pia A Johansson, Romina Vuono, Shaline V Fazal, Thomas Stoker, Bob A Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S Hébert, György Marko-Varga, Malin Parmar, Roger A Barker, Johan Jakobsson
Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667921ae8a7da270bf48986c499fbc03
https://www.repository.cam.ac.uk/handle/1810/332257
https://www.repository.cam.ac.uk/handle/1810/332257
Autor:
Nathalie Cloutier, Eric Boilard, Richard Labib, Michel Panisset, Jérôme Lamontagne-Proulx, Steve Lacroix, Francesca Cicchetti, Jérémie Pilon, Hélèna L Denis, Roger A. Barker, Nicolas Dupré, Arnaud Droit, Antony T. Vincent, Caroline H. Williams-Gray, Mélanie Langlois, Isabelle St-Amour, Sylvain Chouinard, Florence Roux-Dalvai, Anne-Claire Duchez, Sarah L Mason
Publikováno v:
Neurobiology of Disease, Vol 124, Iss, Pp 163-175 (2019)
The production of extracellular vesicles (EV) is a ubiquitous feature of eukaryotic cells but pathological events can affect their formation and constituents. We sought to characterize the nature, profile and protein signature of EV in the plasma of
Autor:
Andrew S. Weyrich, Eric Boilard, Jérôme Lamontagne-Proulx, Isabelle St-Amour, Hélèna L Denis, Marie-Ève Tremblay, Sarah L Mason, Nathalie Cloutier, Peter V Gould, Matthew T. Rondina, Antony T. Vincent, Roger A. Barker, Sylvain Chouinard, Jesse W. Rowley, Francesca Cicchetti
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
Huntington’s disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene which results in the production o