Výsledky vyhledávání - "Isabelle Seugnet"

Akademický článek

Liver X receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status.

Autor: Rym Ghaddab-Zroud, Isabelle Seugnet, Knut R Steffensen, Barbara A Demeneix, Marie-Stéphanie Clerget-Froidevaux

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106983 (2014)

Reversing the escalating rate of obesity requires increased knowledge of the molecular mechanisms controlling energy balance. Liver X receptors (LXRs) and thyroid hormone receptors (TRs) are key physiological regulators of energetic metabolism. Analy

Externí odkaz: https://doaj.org/article/71421671874c4583ab490b12c1e06d67

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Akademický článek

TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo.

Autor: Hajer Guissouma, Rym Ghaddab-Zroud, Isabelle Seugnet, Stéphanie Decherf, Barbara Demeneix, Marie-Stéphanie Clerget-Froidevaux

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95064 (2014)

Mammalian thyroid hormone receptors (TRs) have multiple isoforms, including the bona fide receptors that bind T3 (TRα1, TRβ1 and TRβ2) and a non-hormone-binding variant, TRα2. Intriguingly, TRα2 is strongly expressed in the brain, where its mRNA

Externí odkaz: https://doaj.org/article/77e17994245c41939a429fd1bf30e828

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Down regulation of the liver lipid metabolism induced by hypothyroidism in mice: metabolic flexibility favors compensatory mechanisms in white adipose tissue

Autor: Lamis Chamas, Isabelle Seugnet, Odessa Tanvé, Valérie Enderlin, Marie-Stéphanie Clerget-Froidevaux

In mammals, the maintenance of energy homeostasis relies on complex mechanisms requiring tight synchronization between peripheral organs and the brain. Thyroid hormones (TH), among their pleiotropic actions, play a central role in these regulations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84f195ed96335eb329d2817e4a69e82a
https://doi.org/10.1101/2022.12.22.521639

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Metabolic and neuroinflammatory consequences of hypothyroidism in two mouse strains with different metabolic adaptability capacities, the C57BL/6J and the WSB/EIJ strains

Autor: Marie-Stephanie Clerget-Froidevaux, Lamis Chamas, Isabelle Seugnet, Odessa Tanve, Roseline Poirier, Valerie Enderlin

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de6ab885f1faded42650c6db6ccefd34
https://doi.org/10.1530/endoabs.84.op-13-64

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Hippocampal hypothyroidism in mice promotes glial cell activation and spatial memory deficits

Autor: Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stéphanie Clerget-Froidevaux, Valérie Enderlin

Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in synaptic plasticity. Local reduced levels of thyroid hormones (THs) may impair glia morphology and activity, and promote the inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d9050340ca1626c8a400af42527c0e3
https://doi.org/10.1101/2022.04.06.487389

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A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation

Autor: Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stéphanie Clerget-Froidevaux, Valérie Enderlin

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11938

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c33d996903180b328bcbaa94750e906
https://doi.org/10.3390/ijms231911938

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Reduced central and peripheral inflammatory responses and increased mitochondrial activity contribute to diet-induced obesity resistance in WSB/EiJ mice

Autor: Maria Jesus Herrero, Chakib Djediat, Bolaji Seffou, Lamis Chamas, James Bowers, Evelyne Duvernois-Berthet, Jérémy Terrien, Stéphanie Decherf, Bertrand Ducos, Marie-Stéphanie Clerget-Froidevaux, Barbara A. Demeneix, Isabelle Seugnet

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.19696. ⟨10.1038/s41598-019-56051-4⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)

Energy imbalance due to excess of calories is considered to be a major player in the current worldwide obesity pandemic and could be accompanied by systemic and central inflammation and mitochondrial dysfunctions. This hypothesis was tested by compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f2310dddb70cc711d16b6893e9cfa3
https://hal.archives-ouvertes.fr/hal-03002405

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Specific inflammatory and mitochondrial signatures characterise the WSB/EiJ mice diet-induced obesity resistance capacity: Supplementary Material

Autor: Barbara A. Demeneix, James Bowers, Bertrand Ducos, Maria Jesus Herrero, Lamis Chamas, Stéphanie Decherf, Isabelle Seugnet, Chakib Djediat, Bolaji Seffou, Jérémy Terrien, Marie-Stéphanie Clerget-Froidevaux, Evelyne Duvernois-Berthet

Energy balance disruption due to excess of food is considered to be one of the major players in the current worldwide obesity pandemic. In rodents, a high fat diet (HFD) induces not only obesity, but also inflammation and mitochondrial dysfunctions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c81a2dfb79240d62514a580d83cfbc3

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Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription

Autor: Barbara A. Demeneix, Isabelle Seugnet, Stéphanie Decherf, Marie-Stéphanie Clerget-Froidevaux, Nathalie Becker

Publikováno v: Molecular and Cellular Endocrinology. 381:115-123

How Retinoid X receptors (RXR) and thyroid hormone receptors (TR) interact on negative TREs and whether RXR subtype specificity is determinant in such regulations is unknown. In a set of functional studies, we analyzed RXR subtype effects in T3-depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd3fa351a67b0c28ba1fac440f33023
https://doi.org/10.1016/j.mce.2013.07.016

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Relationship of Thyroid Function with Obesity and Type 2 Diabetes in Euthyroid Tunisian Subjects

Autor: M. Ammar, Hafawa Abid, Slim Jarboui, Amel Benammar Elgaaied, F. Bchir, Rym Berhouma, Isabelle Seugnet, Hajer Guissouma, Kamel Rouissi, Marie-Stéphanie Clerget-Froidevaux, Soumaya Kouidhi, Barbara A. Demeneix

Publikováno v: Endocrine Research
Endocrine Research, 2013, 38 (1), pp.15-23. ⟨10.3109/07435800.2012.699987⟩
Endocrine Research, Taylor & Francis, 2013, 38 (1), pp.15-23. ⟨10.3109/07435800.2012.699987⟩

International audience; Objectives. Although a relationship between obesity and metabolic consequences with thyroid function has been reported, the underlying pathogenesis is not completely known. In the current study, we evaluated the thyroid functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bf9965b2e7af8c70c6cbab372ad5b6
https://doi.org/10.3109/07435800.2012.699987

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